Evaluation of the polypill therapy effectiveness in patients with arterial hypertension and dyslipidemia who underwent COVID-19
Background. To study the dynamics of blood pressure (BP), lipid profile and arterial stiffness after 12 weeks of polypill therapy, including perindopril, indapamide and rosuvastatin. Materials and methods. 40 patients with arterial hypertension (AH) and dyslipidemia who underwent COVID-19 were in...
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| Format: | Article |
| Language: | English |
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Penza State University Publishing House
2024-03-01
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| Series: | Известия высших учебных заведений. Поволжский регион: Медицинские науки |
| Subjects: |
| _version_ | 1827315413619310592 |
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| author | V.E. Oleynikov I.V. Avdeeva K.I. Pavlenko |
| author_facet | V.E. Oleynikov I.V. Avdeeva K.I. Pavlenko |
| author_sort | V.E. Oleynikov |
| collection | DOAJ |
| description | Background. To study the dynamics of blood pressure (BP), lipid profile and arterial
stiffness after 12 weeks of polypill therapy, including perindopril, indapamide and
rosuvastatin. Materials and methods. 40 patients with arterial hypertension (AH) and
dyslipidemia who underwent COVID-19 were included. 35 persons (87.5%) completed the
follow-up period. All patients had their office blood pressure measured using the Korotkov
method. A biochemical blood test was performed to determine total cholesterol, highdensity
lipoproteins (HDL), triglycerides (TG). The level of low-density lipoprotein cholesterol
(LDL) was calculated. With the applanation tonometry, systolic (SDao), diastolic
(DDao) and pulse (PDao) pressure in the aorta, carotid-femoral pulse wave velocity
(PWVcf) were recorded. Results. Against the background of polypill therapy, a decrease in
systolic blood pressure by 18% and diastolic blood pressure by 17% was noted for 12
weeks. The target BP (<140 and 90 mmHg) were achieved in 30 patients (85.7%) after 4
weeks of treatment, and in 34 patients (97.1%) after 12 weeks. There was also a decrease in
OS by 39.6%, TG – by 27.7%, LDL cholesterol – by 51.2%. The target levels of LDL cholesterol
were reached by 23 patients (65.7%). According to the data of applanation tonometry,
a significant decrease in the indicators of central hemodynamics was recorded: SDao –
by 17,5%, DDao – by 12,9%, PDao – by 17,6%, as well as a decrease in PWVcf by 10,1%.
Conclusions. Taking polypill therapy for 12 weeks demonstrated a significant improvement
in the parameters of the lipid profile, a decrease in office and central blood pressure. |
| first_indexed | 2024-04-24T22:54:24Z |
| format | Article |
| id | doaj.art-0e65352fe9e04a8ea16566b390316c1c |
| institution | Directory Open Access Journal |
| issn | 2072-3032 |
| language | English |
| last_indexed | 2024-04-24T22:54:24Z |
| publishDate | 2024-03-01 |
| publisher | Penza State University Publishing House |
| record_format | Article |
| series | Известия высших учебных заведений. Поволжский регион: Медицинские науки |
| spelling | doaj.art-0e65352fe9e04a8ea16566b390316c1c2024-03-18T07:21:55ZengPenza State University Publishing HouseИзвестия высших учебных заведений. Поволжский регион: Медицинские науки2072-30322024-03-01410.21685/2072-3032-2023-4-15Evaluation of the polypill therapy effectiveness in patients with arterial hypertension and dyslipidemia who underwent COVID-19V.E. Oleynikov0I.V. Avdeeva1K.I. Pavlenko2Penza State UniversityPenza State UniversityPenza State UniversityBackground. To study the dynamics of blood pressure (BP), lipid profile and arterial stiffness after 12 weeks of polypill therapy, including perindopril, indapamide and rosuvastatin. Materials and methods. 40 patients with arterial hypertension (AH) and dyslipidemia who underwent COVID-19 were included. 35 persons (87.5%) completed the follow-up period. All patients had their office blood pressure measured using the Korotkov method. A biochemical blood test was performed to determine total cholesterol, highdensity lipoproteins (HDL), triglycerides (TG). The level of low-density lipoprotein cholesterol (LDL) was calculated. With the applanation tonometry, systolic (SDao), diastolic (DDao) and pulse (PDao) pressure in the aorta, carotid-femoral pulse wave velocity (PWVcf) were recorded. Results. Against the background of polypill therapy, a decrease in systolic blood pressure by 18% and diastolic blood pressure by 17% was noted for 12 weeks. The target BP (<140 and 90 mmHg) were achieved in 30 patients (85.7%) after 4 weeks of treatment, and in 34 patients (97.1%) after 12 weeks. There was also a decrease in OS by 39.6%, TG – by 27.7%, LDL cholesterol – by 51.2%. The target levels of LDL cholesterol were reached by 23 patients (65.7%). According to the data of applanation tonometry, a significant decrease in the indicators of central hemodynamics was recorded: SDao – by 17,5%, DDao – by 12,9%, PDao – by 17,6%, as well as a decrease in PWVcf by 10,1%. Conclusions. Taking polypill therapy for 12 weeks demonstrated a significant improvement in the parameters of the lipid profile, a decrease in office and central blood pressure.arterial hypertensionarterial pressurearterial stiffnesslipid profilepolypill therapycovid-19 |
| spellingShingle | V.E. Oleynikov I.V. Avdeeva K.I. Pavlenko Evaluation of the polypill therapy effectiveness in patients with arterial hypertension and dyslipidemia who underwent COVID-19 Известия высших учебных заведений. Поволжский регион: Медицинские науки arterial hypertension arterial pressure arterial stiffness lipid profile polypill therapy covid-19 |
| title | Evaluation of the polypill therapy effectiveness in patients with arterial hypertension and dyslipidemia who underwent COVID-19 |
| title_full | Evaluation of the polypill therapy effectiveness in patients with arterial hypertension and dyslipidemia who underwent COVID-19 |
| title_fullStr | Evaluation of the polypill therapy effectiveness in patients with arterial hypertension and dyslipidemia who underwent COVID-19 |
| title_full_unstemmed | Evaluation of the polypill therapy effectiveness in patients with arterial hypertension and dyslipidemia who underwent COVID-19 |
| title_short | Evaluation of the polypill therapy effectiveness in patients with arterial hypertension and dyslipidemia who underwent COVID-19 |
| title_sort | evaluation of the polypill therapy effectiveness in patients with arterial hypertension and dyslipidemia who underwent covid 19 |
| topic | arterial hypertension arterial pressure arterial stiffness lipid profile polypill therapy covid-19 |
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