Pan-cancer dissection of vasculogenic mimicry characteristic to provide potential therapeutic targets
Introduction:Vasculogenic mimicry (VM) represents a novel form of tumor angiogenesis that is associated with tumor invasiveness and drug resistance. However, the VM landscape across cancer types remains poorly understood. In this study, we elucidate the characterizations of VM across cancers based o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1346719/full |
| _version_ | 1797203074445475840 |
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| author | Haibin Tang Liuxun Chen Xvdong Liu Shengjie Zeng Hao Tan Gang Chen |
| author_facet | Haibin Tang Liuxun Chen Xvdong Liu Shengjie Zeng Hao Tan Gang Chen |
| author_sort | Haibin Tang |
| collection | DOAJ |
| description | Introduction:Vasculogenic mimicry (VM) represents a novel form of tumor angiogenesis that is associated with tumor invasiveness and drug resistance. However, the VM landscape across cancer types remains poorly understood. In this study, we elucidate the characterizations of VM across cancers based on multi-omics data and provide potential targeted therapeutic strategies.Methods:Multi-omics data from The Cancer Genome Atlas was used to conduct comprehensive analyses of the characteristics of VM related genes (VRGs) across cancer types. Pan-cancer vasculogenic mimicry score was established to provide a depiction of the VM landscape across cancer types. The correlation between VM and cancer phenotypes was conducted to explore potential regulatory mechanisms of VM. We further systematically examined the relationship between VM and both tumor immunity and tumor microenvironment (TME). In addition, cell communication analysis based on single-cell transcriptome data was used to investigate the interactions between VM cells and TME. Finally, transcriptional and drug response data from the Genomics of Drug Sensitivity in Cancer database were utilized to identify potential therapeutic targets and drugs. The impact of VM on immunotherapy was also further clarified.Results:Our study revealed that VRGs were dysregulated in tumor and regulated by multiple mechanisms. Then, VM level was found to be heterogeneous among different tumors and correlated with tumor invasiveness, metastatic potential, malignancy, and prognosis. VM was found to be strongly associated with epithelial-mesenchymal transition (EMT). Further analyses revealed cancer-associated fibroblasts can promote EMT and VM formation. Furthermore, the immune-suppressive state is associated with a microenvironment characterized by high levels of VM. VM score can be used as an indicator to predict the effect of immunotherapy. Finally, seven potential drugs targeting VM were identified.Conclusion:In conclusion, we elucidate the characteristics and key regulatory mechanisms of VM across various cancer types, underscoring the pivotal role of CAFs in VM. VM was further found to be associated with the immunosuppressive TME. We also provide clues for the research of drugs targeting VM. Our study provides an initial overview and reference point for future research on VM, opening up new avenues for therapeutic intervention. |
| first_indexed | 2024-04-24T08:13:33Z |
| format | Article |
| id | doaj.art-0e693acdd8774d7ba4b4db0b8cc8644c |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-24T08:13:33Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-0e693acdd8774d7ba4b4db0b8cc8644c2024-04-17T04:33:38ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-04-011510.3389/fphar.2024.13467191346719Pan-cancer dissection of vasculogenic mimicry characteristic to provide potential therapeutic targetsHaibin Tang0Liuxun Chen1Xvdong Liu2Shengjie Zeng3Hao Tan4Gang Chen5Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaIntroduction:Vasculogenic mimicry (VM) represents a novel form of tumor angiogenesis that is associated with tumor invasiveness and drug resistance. However, the VM landscape across cancer types remains poorly understood. In this study, we elucidate the characterizations of VM across cancers based on multi-omics data and provide potential targeted therapeutic strategies.Methods:Multi-omics data from The Cancer Genome Atlas was used to conduct comprehensive analyses of the characteristics of VM related genes (VRGs) across cancer types. Pan-cancer vasculogenic mimicry score was established to provide a depiction of the VM landscape across cancer types. The correlation between VM and cancer phenotypes was conducted to explore potential regulatory mechanisms of VM. We further systematically examined the relationship between VM and both tumor immunity and tumor microenvironment (TME). In addition, cell communication analysis based on single-cell transcriptome data was used to investigate the interactions between VM cells and TME. Finally, transcriptional and drug response data from the Genomics of Drug Sensitivity in Cancer database were utilized to identify potential therapeutic targets and drugs. The impact of VM on immunotherapy was also further clarified.Results:Our study revealed that VRGs were dysregulated in tumor and regulated by multiple mechanisms. Then, VM level was found to be heterogeneous among different tumors and correlated with tumor invasiveness, metastatic potential, malignancy, and prognosis. VM was found to be strongly associated with epithelial-mesenchymal transition (EMT). Further analyses revealed cancer-associated fibroblasts can promote EMT and VM formation. Furthermore, the immune-suppressive state is associated with a microenvironment characterized by high levels of VM. VM score can be used as an indicator to predict the effect of immunotherapy. Finally, seven potential drugs targeting VM were identified.Conclusion:In conclusion, we elucidate the characteristics and key regulatory mechanisms of VM across various cancer types, underscoring the pivotal role of CAFs in VM. VM was further found to be associated with the immunosuppressive TME. We also provide clues for the research of drugs targeting VM. Our study provides an initial overview and reference point for future research on VM, opening up new avenues for therapeutic intervention.https://www.frontiersin.org/articles/10.3389/fphar.2024.1346719/fullvasculogenic mimicrytherapy targetimmunotherapytumor microenvironmentimmunosuppressive microenvironmentpan cancer analysis |
| spellingShingle | Haibin Tang Liuxun Chen Xvdong Liu Shengjie Zeng Hao Tan Gang Chen Pan-cancer dissection of vasculogenic mimicry characteristic to provide potential therapeutic targets Frontiers in Pharmacology vasculogenic mimicry therapy target immunotherapy tumor microenvironment immunosuppressive microenvironment pan cancer analysis |
| title | Pan-cancer dissection of vasculogenic mimicry characteristic to provide potential therapeutic targets |
| title_full | Pan-cancer dissection of vasculogenic mimicry characteristic to provide potential therapeutic targets |
| title_fullStr | Pan-cancer dissection of vasculogenic mimicry characteristic to provide potential therapeutic targets |
| title_full_unstemmed | Pan-cancer dissection of vasculogenic mimicry characteristic to provide potential therapeutic targets |
| title_short | Pan-cancer dissection of vasculogenic mimicry characteristic to provide potential therapeutic targets |
| title_sort | pan cancer dissection of vasculogenic mimicry characteristic to provide potential therapeutic targets |
| topic | vasculogenic mimicry therapy target immunotherapy tumor microenvironment immunosuppressive microenvironment pan cancer analysis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1346719/full |
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