On the correlation between serum Cystatin C and Parkinson’s disease in the Chinese population: a promising biomarker?
As there is no clear biomarker to diagnose Parkinson’s disease, this meta-analysis aims to comprehensively evaluates the correlation between serum Cystatin C levels and Parkinson’s disease in the Chinese population by the meta-analysis method. PubMed, Web of Science, Embase, Cochrane Library, Chin...
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| Format: | Article |
| Language: | English |
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IMR Press
2021-06-01
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| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://jin.imrpress.com/fileup/1757-448X/PDF/1625014731701-746305889.pdf |
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| author | Chang-Gui Yang Si-Min Cai Cui-Yi Liu Chuan Chen |
| author_facet | Chang-Gui Yang Si-Min Cai Cui-Yi Liu Chuan Chen |
| author_sort | Chang-Gui Yang |
| collection | DOAJ |
| description | As there is no clear biomarker to diagnose Parkinson’s disease,
this meta-analysis aims to comprehensively evaluates the correlation between serum
Cystatin C levels and Parkinson’s disease in the Chinese population by the meta-analysis method. PubMed, Web of Science, Embase, Cochrane Library, China national
knowledge infrastructure, and China WanFang databases were systematically
searched on the correlation between serum Cystatin C
and Parkinson’s disease. The results showed that Cystatin C level in Parkinson’s disease patients compared
with the control group, the standardized mean difference = 1.78 (95%
CI: 1.33~2.24, P < 0.05). The level of Cystatin C in the
late Parkinson’s disease stage compared with that in the mid-term of Parkinson’s disease, the standardized mean difference was = 0.78 (95%
CI: 0.08~1.49, P < 0.05). The Cystatin C level in the
mid-term of Parkinson’s disease compared with that in the early Parkinson’s disease stage, the standardized mean difference was 1.24 (95%
CI: 0.35~2.12, P < 0.05). The level of Cystatin C in Parkinson’s disease with
mild cognitive impairment compared with Parkinson’s disease without mild cognitive impairment, the standardized mean difference was 1.29
(95% CI: 0.47~2.10, P < 0.05). The differences were
all statistically significant. In conclusion, a high level of serum Cystatin C may be
involved in the occurrence and development of Parkinson’s disease, whose level is higher
in Parkinson’s disease patients with mild cognitive impairment than that in Parkinson’s disease without mild cognitive impairment. Therefore, Cystatin C in serum is a
promising biomarker for diagnosing Parkinson’s disease. |
| first_indexed | 2024-04-13T23:32:09Z |
| format | Article |
| id | doaj.art-0e695fb83b294b1394a51bfcf9409a41 |
| institution | Directory Open Access Journal |
| issn | 1757-448X |
| language | English |
| last_indexed | 2024-04-13T23:32:09Z |
| publishDate | 2021-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-0e695fb83b294b1394a51bfcf9409a412022-12-22T02:24:51ZengIMR PressJournal of Integrative Neuroscience1757-448X2021-06-0120234935710.31083/j.jin20020341625014731701-746305889On the correlation between serum Cystatin C and Parkinson’s disease in the Chinese population: a promising biomarker?Chang-Gui Yang0Si-Min Cai1Cui-Yi Liu2Chuan Chen3Bagualing Community Health Service Centre, The Eighth Affiliated Hospital, SUN YAT-SEN University, 518033 Shenzhen, Guangdong, ChinaDepartment of Rehabilitation Medicine, The Eighth Affiliated Hospital, SUN YAT-SEN University, 518033 Shenzhen, Guangdong, ChinaDepartment of Rehabilitation Medicine, The Eighth Affiliated Hospital, SUN YAT-SEN University, 518033 Shenzhen, Guangdong, ChinaDepartment of Rehabilitation Medicine, The Eighth Affiliated Hospital, SUN YAT-SEN University, 518033 Shenzhen, Guangdong, ChinaAs there is no clear biomarker to diagnose Parkinson’s disease, this meta-analysis aims to comprehensively evaluates the correlation between serum Cystatin C levels and Parkinson’s disease in the Chinese population by the meta-analysis method. PubMed, Web of Science, Embase, Cochrane Library, China national knowledge infrastructure, and China WanFang databases were systematically searched on the correlation between serum Cystatin C and Parkinson’s disease. The results showed that Cystatin C level in Parkinson’s disease patients compared with the control group, the standardized mean difference = 1.78 (95% CI: 1.33~2.24, P < 0.05). The level of Cystatin C in the late Parkinson’s disease stage compared with that in the mid-term of Parkinson’s disease, the standardized mean difference was = 0.78 (95% CI: 0.08~1.49, P < 0.05). The Cystatin C level in the mid-term of Parkinson’s disease compared with that in the early Parkinson’s disease stage, the standardized mean difference was 1.24 (95% CI: 0.35~2.12, P < 0.05). The level of Cystatin C in Parkinson’s disease with mild cognitive impairment compared with Parkinson’s disease without mild cognitive impairment, the standardized mean difference was 1.29 (95% CI: 0.47~2.10, P < 0.05). The differences were all statistically significant. In conclusion, a high level of serum Cystatin C may be involved in the occurrence and development of Parkinson’s disease, whose level is higher in Parkinson’s disease patients with mild cognitive impairment than that in Parkinson’s disease without mild cognitive impairment. Therefore, Cystatin C in serum is a promising biomarker for diagnosing Parkinson’s disease.https://jin.imrpress.com/fileup/1757-448X/PDF/1625014731701-746305889.pdfcystatin cparkinson's diseasemeta-analysismild cognitive impairment |
| spellingShingle | Chang-Gui Yang Si-Min Cai Cui-Yi Liu Chuan Chen On the correlation between serum Cystatin C and Parkinson’s disease in the Chinese population: a promising biomarker? Journal of Integrative Neuroscience cystatin c parkinson's disease meta-analysis mild cognitive impairment |
| title | On the correlation between serum Cystatin C and Parkinson’s disease in the Chinese population: a promising biomarker? |
| title_full | On the correlation between serum Cystatin C and Parkinson’s disease in the Chinese population: a promising biomarker? |
| title_fullStr | On the correlation between serum Cystatin C and Parkinson’s disease in the Chinese population: a promising biomarker? |
| title_full_unstemmed | On the correlation between serum Cystatin C and Parkinson’s disease in the Chinese population: a promising biomarker? |
| title_short | On the correlation between serum Cystatin C and Parkinson’s disease in the Chinese population: a promising biomarker? |
| title_sort | on the correlation between serum cystatin c and parkinson s disease in the chinese population a promising biomarker |
| topic | cystatin c parkinson's disease meta-analysis mild cognitive impairment |
| url | https://jin.imrpress.com/fileup/1757-448X/PDF/1625014731701-746305889.pdf |
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