An Informative Review of Radiomics Studies on Cancer Imaging: The Main Findings, Challenges and Limitations of the Methodologies
The aim of this informative review was to investigate the application of radiomics in cancer imaging and to summarize the results of recent studies to support oncological imaging with particular attention to breast cancer, rectal cancer and primitive and secondary liver cancer. This review also aims...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/31/1/27 |
| _version_ | 1827372514530033664 |
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| author | Roberta Fusco Vincenza Granata Igino Simonetti Sergio Venanzio Setola Maria Assunta Daniela Iasevoli Filippo Tovecci Ciro Michele Paolo Lamanna Francesco Izzo Biagio Pecori Antonella Petrillo |
| author_facet | Roberta Fusco Vincenza Granata Igino Simonetti Sergio Venanzio Setola Maria Assunta Daniela Iasevoli Filippo Tovecci Ciro Michele Paolo Lamanna Francesco Izzo Biagio Pecori Antonella Petrillo |
| author_sort | Roberta Fusco |
| collection | DOAJ |
| description | The aim of this informative review was to investigate the application of radiomics in cancer imaging and to summarize the results of recent studies to support oncological imaging with particular attention to breast cancer, rectal cancer and primitive and secondary liver cancer. This review also aims to provide the main findings, challenges and limitations of the current methodologies. Clinical studies published in the last four years (2019–2022) were included in this review. Among the 19 studies analyzed, none assessed the differences between scanners and vendor-dependent characteristics, collected images of individuals at additional points in time, performed calibration statistics, represented a prospective study performed and registered in a study database, conducted a cost-effectiveness analysis, reported on the cost-effectiveness of the clinical application, or performed multivariable analysis with also non-radiomics features. Seven studies reached a high radiomic quality score (RQS), and seventeen earned additional points by using validation steps considering two datasets from two distinct institutes and open science and data domains (radiomics features calculated on a set of representative ROIs are open source). The potential of radiomics is increasingly establishing itself, even if there are still several aspects to be evaluated before the passage of radiomics into routine clinical practice. There are several challenges, including the need for standardization across all stages of the workflow and the potential for cross-site validation using real-world heterogeneous datasets. Moreover, multiple centers and prospective radiomics studies with more samples that add inter-scanner differences and vendor-dependent characteristics will be needed in the future, as well as the collecting of images of individuals at additional time points, the reporting of calibration statistics and the performing of prospective studies registered in a study database. |
| first_indexed | 2024-03-08T11:00:47Z |
| format | Article |
| id | doaj.art-0e69887b99574183a1cec043db44df7d |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-08T11:00:47Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-0e69887b99574183a1cec043db44df7d2024-01-26T15:57:51ZengMDPI AGCurrent Oncology1198-00521718-77292024-01-0131140342410.3390/curroncol31010027An Informative Review of Radiomics Studies on Cancer Imaging: The Main Findings, Challenges and Limitations of the MethodologiesRoberta Fusco0Vincenza Granata1Igino Simonetti2Sergio Venanzio Setola3Maria Assunta Daniela Iasevoli4Filippo Tovecci5Ciro Michele Paolo Lamanna6Francesco Izzo7Biagio Pecori8Antonella Petrillo9Medical Oncology Division, Igea SpA, 80013 Naples, ItalyDivision of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale—IRCCS di Napoli, 80131 Naples, ItalyDivision of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale—IRCCS di Napoli, 80131 Naples, ItalyDivision of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale—IRCCS di Napoli, 80131 Naples, ItalyDivision of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale—IRCCS di Napoli, 80131 Naples, ItalyDivision of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale—IRCCS di Napoli, 80131 Naples, ItalyDivision of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale—IRCCS di Napoli, 80131 Naples, ItalyDivision of Epatobiliary Surgical Oncology, Istituto Nazionale Tumori IRCCS Fondazione Pascale—IRCCS di Napoli, 80131 Naples, ItalyDivision of Radiation Protection and Innovative Technology, Istituto Nazionale Tumori IRCCS Fondazione Pascale—IRCCS di Napoli, 80131 Naples, ItalyDivision of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale—IRCCS di Napoli, 80131 Naples, ItalyThe aim of this informative review was to investigate the application of radiomics in cancer imaging and to summarize the results of recent studies to support oncological imaging with particular attention to breast cancer, rectal cancer and primitive and secondary liver cancer. This review also aims to provide the main findings, challenges and limitations of the current methodologies. Clinical studies published in the last four years (2019–2022) were included in this review. Among the 19 studies analyzed, none assessed the differences between scanners and vendor-dependent characteristics, collected images of individuals at additional points in time, performed calibration statistics, represented a prospective study performed and registered in a study database, conducted a cost-effectiveness analysis, reported on the cost-effectiveness of the clinical application, or performed multivariable analysis with also non-radiomics features. Seven studies reached a high radiomic quality score (RQS), and seventeen earned additional points by using validation steps considering two datasets from two distinct institutes and open science and data domains (radiomics features calculated on a set of representative ROIs are open source). The potential of radiomics is increasingly establishing itself, even if there are still several aspects to be evaluated before the passage of radiomics into routine clinical practice. There are several challenges, including the need for standardization across all stages of the workflow and the potential for cross-site validation using real-world heterogeneous datasets. Moreover, multiple centers and prospective radiomics studies with more samples that add inter-scanner differences and vendor-dependent characteristics will be needed in the future, as well as the collecting of images of individuals at additional time points, the reporting of calibration statistics and the performing of prospective studies registered in a study database.https://www.mdpi.com/1718-7729/31/1/27biomedical imagingradiomicsmachine learningdeep learning |
| spellingShingle | Roberta Fusco Vincenza Granata Igino Simonetti Sergio Venanzio Setola Maria Assunta Daniela Iasevoli Filippo Tovecci Ciro Michele Paolo Lamanna Francesco Izzo Biagio Pecori Antonella Petrillo An Informative Review of Radiomics Studies on Cancer Imaging: The Main Findings, Challenges and Limitations of the Methodologies Current Oncology biomedical imaging radiomics machine learning deep learning |
| title | An Informative Review of Radiomics Studies on Cancer Imaging: The Main Findings, Challenges and Limitations of the Methodologies |
| title_full | An Informative Review of Radiomics Studies on Cancer Imaging: The Main Findings, Challenges and Limitations of the Methodologies |
| title_fullStr | An Informative Review of Radiomics Studies on Cancer Imaging: The Main Findings, Challenges and Limitations of the Methodologies |
| title_full_unstemmed | An Informative Review of Radiomics Studies on Cancer Imaging: The Main Findings, Challenges and Limitations of the Methodologies |
| title_short | An Informative Review of Radiomics Studies on Cancer Imaging: The Main Findings, Challenges and Limitations of the Methodologies |
| title_sort | informative review of radiomics studies on cancer imaging the main findings challenges and limitations of the methodologies |
| topic | biomedical imaging radiomics machine learning deep learning |
| url | https://www.mdpi.com/1718-7729/31/1/27 |
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