| Summary: | <i>Sonchus arvensis</i> Linn. and <i>Hemerocallis citrina</i> Baroni. have been reported to improve body resistance. However, the underlying mechanism is not clear. In this study, <i>Sonchus arvensis</i> Linn. phenolic compounds (SAP) and <i>Hemerocallis citrina</i> Baroni. phenolic compounds (HCP) were extracted and their protective effects in <i>Caenorhabditis elegans</i> evaluated. SAP and HCP showed considerably different phenolic compositions. In the normal <i>C. elegans</i> model, HCP exhibited better effects in promoting growth than SAP. In the sucrose-incubated <i>C. elegans</i> model, both SAP and HCP showed positive effects against the high-sucrose-induced damage. In the stearic acid-incubated <i>C. elegans</i> model, both SAP and HCP improved lifespan, reproductive ability and growth, while HCP had a more evident effect than SAP on reproductive ability. The TGF-β signaling pathway was confirmed to be involved in the protective effects of SAP and HCP. The antioxidant ability of SAP was also found to be related to <i>skn-1</i>. Our study shows that both SAP and HCP have protective effects against high sucrose- or high stearic acid-induced damage.
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