A new inbred strain of Fawn-Hooded rats demonstrates mania-like behavioural and monoaminergic abnormalities
The Fawn-Hooded (FH) rat carries a gene mutation that results in a dysfunctional serotoninergic system. However, previous studies have reported differing features between the FH/Wjd and FH/Har strains. We aimed to compare the behavioural and neurobiological features of FH/HamSlc rats with those of F...
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| Format: | Article |
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Elsevier
2019-12-01
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| Series: | IBRO Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451830119319326 |
| _version_ | 1818390361987350528 |
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| author | Hirotsugu Azechi Kōsuke Hakamada Takanobu Yamamoto |
| author_facet | Hirotsugu Azechi Kōsuke Hakamada Takanobu Yamamoto |
| author_sort | Hirotsugu Azechi |
| collection | DOAJ |
| description | The Fawn-Hooded (FH) rat carries a gene mutation that results in a dysfunctional serotoninergic system. However, previous studies have reported differing features between the FH/Wjd and FH/Har strains. We aimed to compare the behavioural and neurobiological features of FH/HamSlc rats with those of Fischer 344 rats. We performed the open field, elevated minus-maze, Y-maze spontaneous alternation, and forced swim tests to investigate behavioural alterations. We also assessed neurobiological characteristics by quantifying monoamines and their related compounds in the prefrontal cortex, hippocampus, and striatum using high-performance liquid chromatography with an electrochemical detection system. FH/HamSlc rats showed hyperactivity and a high impulsivity tendency in the open field and the elevated minus maze test, but no cognitive dysfunction. In addition, the hyperactivity was suppressed immediately after the forced swim test. FH/HamSlc rats showed low dopamine levels, but high dopamine turnover in the striatum. Serotonin and noradrenaline levels were low in the prefrontal cortex and the hippocampus of FH/HamSlc rats, but high serotonin turnover was observed in the prefrontal cortex, hippocampus, and striatum. FH/HamSlc rats show (1) mania-like behavioural characteristics that are different from those of other strains of FH rats; (2) stimulus dependent suppression of hyperactivity similar to the clinical findings that exercise alleviates the symptoms of bipolar disorder; and (3) monoaminergic dysregulation such as monoamine imbalance and hyperturnover that may be associated with mania-related behavioural characteristics. Thus, the FH/HamSlc rat is a new animal model for mania including bipolar disorder. Keywords: Fawn-Hooded rat, Hyperactivity, Impulsivity, Stimulus responsivity, Monoaminergic dysregulation, Bipolar mania model |
| first_indexed | 2024-12-14T04:56:25Z |
| format | Article |
| id | doaj.art-0e72edac6edf4da081593f844fb4c8f9 |
| institution | Directory Open Access Journal |
| issn | 2451-8301 |
| language | English |
| last_indexed | 2024-12-14T04:56:25Z |
| publishDate | 2019-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Reports |
| spelling | doaj.art-0e72edac6edf4da081593f844fb4c8f92022-12-21T23:16:20ZengElsevierIBRO Reports2451-83012019-12-01798106A new inbred strain of Fawn-Hooded rats demonstrates mania-like behavioural and monoaminergic abnormalitiesHirotsugu Azechi0Kōsuke Hakamada1Takanobu Yamamoto2Department of Psychology, Tezukayama University, Nara 631-8585, Japan; Corresponding author at: Graduate School of Brain Science, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe-shi, Kyoto 610-0394, Japan.Department of Neurophysiology and Cognitive Neuroscience, Graduate School of Psychological Sciences, Tezukayama University, Nara 631-8585, JapanDepartment of Psychology, Tezukayama University, Nara 631-8585, Japan; Department of Neurophysiology and Cognitive Neuroscience, Graduate School of Psychological Sciences, Tezukayama University, Nara 631-8585, JapanThe Fawn-Hooded (FH) rat carries a gene mutation that results in a dysfunctional serotoninergic system. However, previous studies have reported differing features between the FH/Wjd and FH/Har strains. We aimed to compare the behavioural and neurobiological features of FH/HamSlc rats with those of Fischer 344 rats. We performed the open field, elevated minus-maze, Y-maze spontaneous alternation, and forced swim tests to investigate behavioural alterations. We also assessed neurobiological characteristics by quantifying monoamines and their related compounds in the prefrontal cortex, hippocampus, and striatum using high-performance liquid chromatography with an electrochemical detection system. FH/HamSlc rats showed hyperactivity and a high impulsivity tendency in the open field and the elevated minus maze test, but no cognitive dysfunction. In addition, the hyperactivity was suppressed immediately after the forced swim test. FH/HamSlc rats showed low dopamine levels, but high dopamine turnover in the striatum. Serotonin and noradrenaline levels were low in the prefrontal cortex and the hippocampus of FH/HamSlc rats, but high serotonin turnover was observed in the prefrontal cortex, hippocampus, and striatum. FH/HamSlc rats show (1) mania-like behavioural characteristics that are different from those of other strains of FH rats; (2) stimulus dependent suppression of hyperactivity similar to the clinical findings that exercise alleviates the symptoms of bipolar disorder; and (3) monoaminergic dysregulation such as monoamine imbalance and hyperturnover that may be associated with mania-related behavioural characteristics. Thus, the FH/HamSlc rat is a new animal model for mania including bipolar disorder. Keywords: Fawn-Hooded rat, Hyperactivity, Impulsivity, Stimulus responsivity, Monoaminergic dysregulation, Bipolar mania modelhttp://www.sciencedirect.com/science/article/pii/S2451830119319326 |
| spellingShingle | Hirotsugu Azechi Kōsuke Hakamada Takanobu Yamamoto A new inbred strain of Fawn-Hooded rats demonstrates mania-like behavioural and monoaminergic abnormalities IBRO Reports |
| title | A new inbred strain of Fawn-Hooded rats demonstrates mania-like behavioural and monoaminergic abnormalities |
| title_full | A new inbred strain of Fawn-Hooded rats demonstrates mania-like behavioural and monoaminergic abnormalities |
| title_fullStr | A new inbred strain of Fawn-Hooded rats demonstrates mania-like behavioural and monoaminergic abnormalities |
| title_full_unstemmed | A new inbred strain of Fawn-Hooded rats demonstrates mania-like behavioural and monoaminergic abnormalities |
| title_short | A new inbred strain of Fawn-Hooded rats demonstrates mania-like behavioural and monoaminergic abnormalities |
| title_sort | new inbred strain of fawn hooded rats demonstrates mania like behavioural and monoaminergic abnormalities |
| url | http://www.sciencedirect.com/science/article/pii/S2451830119319326 |
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