Safety and Quality of Life in Women with Immediate Reconstruction with Polyurethane Implants after Neoadjuvant Chemotherapy: Outcomes from The Preq-20 Trial
Introduction: Various studies have evaluated the impact of neoadjuvant chemotherapy (NAC) on the complications of breast cancer surgery, most of which were retrospective and did not assess the variables related to postoperative risk factors. The aim of this study is to analyse the safety and satisfa...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/4/1113 |
| _version_ | 1797621833552363520 |
|---|---|
| author | Benigno Acea-Nebril Alejandra García-Novoa Carmen Cereijo-Garea Carmen Conde Iglesias Alberto Bouzón Alejandro Carlota Díaz Carballada |
| author_facet | Benigno Acea-Nebril Alejandra García-Novoa Carmen Cereijo-Garea Carmen Conde Iglesias Alberto Bouzón Alejandro Carlota Díaz Carballada |
| author_sort | Benigno Acea-Nebril |
| collection | DOAJ |
| description | Introduction: Various studies have evaluated the impact of neoadjuvant chemotherapy (NAC) on the complications of breast cancer surgery, most of which were retrospective and did not assess the variables related to postoperative risk factors. The aim of this study is to analyse the safety and satisfaction of women included in the PreQ-20 trial who underwent NAC and who underwent mastectomy and immediate reconstruction with prepectoral polyurethane implants. Material and Methods: The patients included in the study belong to the prospective study PreQ-20. The study group consisted of patients who underwent immediate reconstruction after primary systemic therapy. The control groups consisted of patients with immediate reconstruction and adjuvant chemotherapy (control group 1) and patients with an infiltrating carcinoma or in situ ductal carcinoma who did not require chemotherapy (control group 2). Results: The study included 157 women, 58 (36.9%) of whom underwent primary systemic therapy. The indication for genetic study was significantly greater for the study group (87.9%) than for control groups 1 (49.1%) or 2 (30.4%). Seventy-two (45.9%) of the patients underwent bilateral mastectomy (BM), a procedure that was performed significantly more frequently in the study group (69%) than in control groups 1 (30.2%) or 2 (34.8%). The incidence rate for BM after complete pathologic response was 78%. There were no statistically significant differences in the number of complications between the groups. Implant loss was significantly more frequent in control group 1 (13.2%) than in the study group (3.4%) and control group 2 (2.2%). Conclusions: Mastectomy with prepectoral polyurethane implant reconstruction in patients with neoadjuvant chemotherapy presented a similar incidence of complications compared with patients who underwent primary surgery. There is a high rate of BM in women with NAC. |
| first_indexed | 2024-03-11T09:02:37Z |
| format | Article |
| id | doaj.art-0e7526dc6eb14887b9fa61b0e522cfa8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:02:37Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0e7526dc6eb14887b9fa61b0e522cfa82023-11-16T19:36:22ZengMDPI AGCancers2072-66942023-02-01154111310.3390/cancers15041113Safety and Quality of Life in Women with Immediate Reconstruction with Polyurethane Implants after Neoadjuvant Chemotherapy: Outcomes from The Preq-20 TrialBenigno Acea-Nebril0Alejandra García-Novoa1Carmen Cereijo-Garea2Carmen Conde Iglesias3Alberto Bouzón Alejandro4Carlota Díaz Carballada5Breast Unit, Department of General Surgery, University Hospital Complex A Coruña, 15006 A Coruña, SpainBreast Unit, Department of General Surgery, University Hospital Complex A Coruña, 15006 A Coruña, SpainBreast Unit, University Hospital Complex A Coruña, 15006 A Coruña, SpainBreast Unit, Ginecology Service, University Hospital Complex A Coruña, 15006 A Coruña, SpainBreast Unit, Department of General Surgery, University Hospital Complex A Coruña, 15006 A Coruña, SpainBreast Unit, Ginecology Service, University Hospital Complex A Coruña, 15006 A Coruña, SpainIntroduction: Various studies have evaluated the impact of neoadjuvant chemotherapy (NAC) on the complications of breast cancer surgery, most of which were retrospective and did not assess the variables related to postoperative risk factors. The aim of this study is to analyse the safety and satisfaction of women included in the PreQ-20 trial who underwent NAC and who underwent mastectomy and immediate reconstruction with prepectoral polyurethane implants. Material and Methods: The patients included in the study belong to the prospective study PreQ-20. The study group consisted of patients who underwent immediate reconstruction after primary systemic therapy. The control groups consisted of patients with immediate reconstruction and adjuvant chemotherapy (control group 1) and patients with an infiltrating carcinoma or in situ ductal carcinoma who did not require chemotherapy (control group 2). Results: The study included 157 women, 58 (36.9%) of whom underwent primary systemic therapy. The indication for genetic study was significantly greater for the study group (87.9%) than for control groups 1 (49.1%) or 2 (30.4%). Seventy-two (45.9%) of the patients underwent bilateral mastectomy (BM), a procedure that was performed significantly more frequently in the study group (69%) than in control groups 1 (30.2%) or 2 (34.8%). The incidence rate for BM after complete pathologic response was 78%. There were no statistically significant differences in the number of complications between the groups. Implant loss was significantly more frequent in control group 1 (13.2%) than in the study group (3.4%) and control group 2 (2.2%). Conclusions: Mastectomy with prepectoral polyurethane implant reconstruction in patients with neoadjuvant chemotherapy presented a similar incidence of complications compared with patients who underwent primary surgery. There is a high rate of BM in women with NAC.https://www.mdpi.com/2072-6694/15/4/1113prepectoral breast reconstructionpolyurethane implantsneoadjuvant chemotherapy |
| spellingShingle | Benigno Acea-Nebril Alejandra García-Novoa Carmen Cereijo-Garea Carmen Conde Iglesias Alberto Bouzón Alejandro Carlota Díaz Carballada Safety and Quality of Life in Women with Immediate Reconstruction with Polyurethane Implants after Neoadjuvant Chemotherapy: Outcomes from The Preq-20 Trial Cancers prepectoral breast reconstruction polyurethane implants neoadjuvant chemotherapy |
| title | Safety and Quality of Life in Women with Immediate Reconstruction with Polyurethane Implants after Neoadjuvant Chemotherapy: Outcomes from The Preq-20 Trial |
| title_full | Safety and Quality of Life in Women with Immediate Reconstruction with Polyurethane Implants after Neoadjuvant Chemotherapy: Outcomes from The Preq-20 Trial |
| title_fullStr | Safety and Quality of Life in Women with Immediate Reconstruction with Polyurethane Implants after Neoadjuvant Chemotherapy: Outcomes from The Preq-20 Trial |
| title_full_unstemmed | Safety and Quality of Life in Women with Immediate Reconstruction with Polyurethane Implants after Neoadjuvant Chemotherapy: Outcomes from The Preq-20 Trial |
| title_short | Safety and Quality of Life in Women with Immediate Reconstruction with Polyurethane Implants after Neoadjuvant Chemotherapy: Outcomes from The Preq-20 Trial |
| title_sort | safety and quality of life in women with immediate reconstruction with polyurethane implants after neoadjuvant chemotherapy outcomes from the preq 20 trial |
| topic | prepectoral breast reconstruction polyurethane implants neoadjuvant chemotherapy |
| url | https://www.mdpi.com/2072-6694/15/4/1113 |
| work_keys_str_mv | AT benignoaceanebril safetyandqualityoflifeinwomenwithimmediatereconstructionwithpolyurethaneimplantsafterneoadjuvantchemotherapyoutcomesfromthepreq20trial AT alejandragarcianovoa safetyandqualityoflifeinwomenwithimmediatereconstructionwithpolyurethaneimplantsafterneoadjuvantchemotherapyoutcomesfromthepreq20trial AT carmencereijogarea safetyandqualityoflifeinwomenwithimmediatereconstructionwithpolyurethaneimplantsafterneoadjuvantchemotherapyoutcomesfromthepreq20trial AT carmencondeiglesias safetyandqualityoflifeinwomenwithimmediatereconstructionwithpolyurethaneimplantsafterneoadjuvantchemotherapyoutcomesfromthepreq20trial AT albertobouzonalejandro safetyandqualityoflifeinwomenwithimmediatereconstructionwithpolyurethaneimplantsafterneoadjuvantchemotherapyoutcomesfromthepreq20trial AT carlotadiazcarballada safetyandqualityoflifeinwomenwithimmediatereconstructionwithpolyurethaneimplantsafterneoadjuvantchemotherapyoutcomesfromthepreq20trial |