Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathy
Abstract Background Neuregulin 4 (Nrg4) is a novel neurotrophic adipokine associated with the development of diabetic peripheral neuropathy (DPN), however, the pathological mechanism remains poorly understood. The purpose of our study was to investigate the association of circulating Nrg4 with DPN a...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | http://link.springer.com/article/10.1186/s13098-020-00550-2 |
| _version_ | 1811328632092622848 |
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| author | Pijun Yan Zhihong Zhang Ying Miao Yong Xu Jianhua Zhu Qin Wan |
| author_facet | Pijun Yan Zhihong Zhang Ying Miao Yong Xu Jianhua Zhu Qin Wan |
| author_sort | Pijun Yan |
| collection | DOAJ |
| description | Abstract Background Neuregulin 4 (Nrg4) is a novel neurotrophic adipokine associated with the development of diabetic peripheral neuropathy (DPN), however, the pathological mechanism remains poorly understood. The purpose of our study was to investigate the association of circulating Nrg4 with DPN and 25-hydroxy vitamin D [25(OH)D], a multifunctional secosteroid hormone that regulates other neurotrophic factors and adipokines gene expression, and other diabetic vascular complications. Methods Circulating Nrg4 levels were measured with an ELISA kit in 164 newly diagnosed type 2 diabetes mellitus (nT2DM) patients. The relationship between circulating Nrg4 and DPN and other parameters was analyzed. Results Circulating Nrg4 levels were significantly lower in nT2DM patients with DPN than those without, and subjects in the highest quartile of circulating Nrg4 had significantly lower vibration perception threshold (VPT), the prevalence of DPN, the proportion of persons with VPT > 25 V, and significantly higher circulating 25(OH)D (all P < 0.01). Moreover, circulating Nrg4 was positively and independently associated with 25(OH)D, and was negatively with VPT (P < 0.01 or P < 0.05), but showed no associations with the prevalence of peripheral arterial disease, diabetic nephropathy, and diabetic retinopathy (all P > 0.05). Additionally,the prevalence of DPN and risk of DPN development were progressively decreased with increasing circulating Nrg4 quartiles, independently of potential confounding factors. Conclusions These data demonstrate that decreased levels of circulating Nrg4 might lead to the development of DPN through its close interaction with circulating 25(OH)D not with other diabetic vascular complications. Further prospective studies are needed to identify our findings in these populations. |
| first_indexed | 2024-04-13T15:28:29Z |
| format | Article |
| id | doaj.art-0e758cbd725546a69306f13d574a3780 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-13T15:28:29Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-0e758cbd725546a69306f13d574a37802022-12-22T02:41:26ZengBMCDiabetology & Metabolic Syndrome1758-59962020-05-0112111110.1186/s13098-020-00550-2Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathyPijun Yan0Zhihong Zhang1Ying Miao2Yong Xu3Jianhua Zhu4Qin Wan5Department of Endocrinology, The Affiliated Hospital of Southwest Medical UniversityDepartment of General Medicine, The Affiliated Hospital of Southwest Medical UniversityDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Endocrinology, The Affiliated Hospital of Southwest Medical UniversityAbstract Background Neuregulin 4 (Nrg4) is a novel neurotrophic adipokine associated with the development of diabetic peripheral neuropathy (DPN), however, the pathological mechanism remains poorly understood. The purpose of our study was to investigate the association of circulating Nrg4 with DPN and 25-hydroxy vitamin D [25(OH)D], a multifunctional secosteroid hormone that regulates other neurotrophic factors and adipokines gene expression, and other diabetic vascular complications. Methods Circulating Nrg4 levels were measured with an ELISA kit in 164 newly diagnosed type 2 diabetes mellitus (nT2DM) patients. The relationship between circulating Nrg4 and DPN and other parameters was analyzed. Results Circulating Nrg4 levels were significantly lower in nT2DM patients with DPN than those without, and subjects in the highest quartile of circulating Nrg4 had significantly lower vibration perception threshold (VPT), the prevalence of DPN, the proportion of persons with VPT > 25 V, and significantly higher circulating 25(OH)D (all P < 0.01). Moreover, circulating Nrg4 was positively and independently associated with 25(OH)D, and was negatively with VPT (P < 0.01 or P < 0.05), but showed no associations with the prevalence of peripheral arterial disease, diabetic nephropathy, and diabetic retinopathy (all P > 0.05). Additionally,the prevalence of DPN and risk of DPN development were progressively decreased with increasing circulating Nrg4 quartiles, independently of potential confounding factors. Conclusions These data demonstrate that decreased levels of circulating Nrg4 might lead to the development of DPN through its close interaction with circulating 25(OH)D not with other diabetic vascular complications. Further prospective studies are needed to identify our findings in these populations.http://link.springer.com/article/10.1186/s13098-020-00550-2Neuregulin 4Diabetic peripheral neuropathyDiabetic vascularComplications25-hydroxy vitamin D |
| spellingShingle | Pijun Yan Zhihong Zhang Ying Miao Yong Xu Jianhua Zhu Qin Wan Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathy Diabetology & Metabolic Syndrome Neuregulin 4 Diabetic peripheral neuropathy Diabetic vascular Complications 25-hydroxy vitamin D |
| title | Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathy |
| title_full | Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathy |
| title_fullStr | Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathy |
| title_full_unstemmed | Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathy |
| title_short | Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathy |
| title_sort | changes of circulating neuregulin 4 and its relationship with 25 hydroxy vitamin d and other diabetic vascular complications in patients with diabetic peripheral neuropathy |
| topic | Neuregulin 4 Diabetic peripheral neuropathy Diabetic vascular Complications 25-hydroxy vitamin D |
| url | http://link.springer.com/article/10.1186/s13098-020-00550-2 |
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