Dual Activation of Phosphodiesterase 3 and 4 Regulates Basal Cardiac Pacemaker Function and Beyond

Dual Activation of Phosphodiesterase 3 and 4 Regulates Basal Cardiac Pacemaker Function and Beyond

The sinoatrial (SA) node is the physiological pacemaker of the heart, and resting heart rate in humans is a well-known risk factor for cardiovascular disease and mortality. Consequently, the mechanisms of initiating and regulating the normal spontaneous SA node beating rate are of vital importance....

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Bibliographic Details
Main Authors:	Tatiana M. Vinogradova, Edward G. Lakatta
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Series:	International Journal of Molecular Sciences
Subjects:	sinoatrial node phosphodiesterase adenylyl cyclase cardiac pacemaker cells local Ca<sup>2+</sup> release sarcoplasmic reticulum
Online Access:	https://www.mdpi.com/1422-0067/22/16/8414

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