Routine use of immunosuppressants is associated with mortality in hospitalised patients with COVID-19
Background: Whilst there is literature on the impact of SARS viruses in the severely immunosuppressed, less is known about the link between routine immunosuppressant use and outcome in COVID-19. Consequently, guidelines on their use vary depending on specific patient populations. Methods: The study...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-02-01
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| Series: | Therapeutic Advances in Drug Safety |
| Online Access: | https://doi.org/10.1177/2042098620985690 |
| _version_ | 1819053587975634944 |
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| author | Phyo K. Myint Ben Carter Fenella Barlow-Pay Roxanna Short Alice G. Einarsson Eilidh Bruce Kathryn McCarthy Alessia Verduri Jemima Collins James Hesford Frances Rickard Emma Mitchell Mark Holloway Aine McGovern Arturo Vilches-Moraga Philip Braude Lyndsay Pearce Michael Stechman Angeline Price Terence J. Quinn Enrico Clini Susan Moug Jonathan Hewitt |
| author_facet | Phyo K. Myint Ben Carter Fenella Barlow-Pay Roxanna Short Alice G. Einarsson Eilidh Bruce Kathryn McCarthy Alessia Verduri Jemima Collins James Hesford Frances Rickard Emma Mitchell Mark Holloway Aine McGovern Arturo Vilches-Moraga Philip Braude Lyndsay Pearce Michael Stechman Angeline Price Terence J. Quinn Enrico Clini Susan Moug Jonathan Hewitt |
| author_sort | Phyo K. Myint |
| collection | DOAJ |
| description | Background: Whilst there is literature on the impact of SARS viruses in the severely immunosuppressed, less is known about the link between routine immunosuppressant use and outcome in COVID-19. Consequently, guidelines on their use vary depending on specific patient populations. Methods: The study population was drawn from the COPE Study (COVID-19 in Older People), a multicentre observational cohort study, across the UK and Italy. Data were collected between 27 February and 28 April 2020 by trained data-collectors and included all unselected consecutive admissions with COVID-19. Load (name/number of medications) and dosage of immunosuppressant were collected along with other covariate data. Primary outcome was time-to-mortality from the date of admission (or) date of diagnosis, if diagnosis was five or more days after admission. Secondary outcomes were Day-14 mortality and time-to-discharge. Data were analysed with mixed-effects, Cox proportional hazards and logistic regression models using non-users of immunosuppressants as the reference group. Results: In total 1184 patients were eligible for inclusion. The median (IQR) age was 74 (62–83), 676 (57%) were male, and 299 (25.3%) died in hospital (total person follow-up 15,540 days). Most patients exhibited at least one comorbidity, and 113 (~10%) were on immunosuppressants. Any immunosuppressant use was associated with increased mortality: aHR 1.87, 95% CI: 1.30, 2.69 (time to mortality) and aOR 1.71, 95% CI: 1.01–2.88 (14-day mortality). There also appeared to be a dose–response relationship. Conclusion: Despite possible indication bias, until further evidence emerges we recommend adhering to public health measures, a low threshold to seek medical advice and close monitoring of symptoms in those who take immunosuppressants routinely regardless of their indication. However, it should be noted that the inability to control for the underlying condition requiring immunosuppressants is a major limitation, and hence caution should be exercised in interpretation of the results. Plain Language Summary Regular Use of Immune Suppressing Drugs is Associated with Increased Risk of Death in Hospitalised Patients with COVID-19 Background: We do not have much information on how the COVID-19 virus affects patients who use immunosuppressants, drugs which inhibit or reduce the activity of the immune system. There are various conflicting views on whether immune-suppressing drugs are beneficial or detrimental in patients with the disease. Methods: This study collected data from 10 hospitals in the UK and one in Italy between February and April 2020 in order to identify any association between the regular use of immunosuppressant medicines and survival in patients who were admitted to hospital with COVID-19. Results: 1184 patients were included in the study, and 10% of them were using immunosuppressants. Any immunosuppressant use was associated with increased risk of death, and the risk appeared to increase if the dose of the medicine was higher. Conclusion: We therefore recommend that patients who take immunosuppressant medicines routinely should carefully adhere to social distancing measures, and seek medical attention early during the COVID-19 pandemic. |
| first_indexed | 2024-12-21T12:38:06Z |
| format | Article |
| id | doaj.art-0e78b59fc0224f0b8b0927e67e440a54 |
| institution | Directory Open Access Journal |
| issn | 2042-0994 |
| language | English |
| last_indexed | 2024-12-21T12:38:06Z |
| publishDate | 2021-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Drug Safety |
| spelling | doaj.art-0e78b59fc0224f0b8b0927e67e440a542022-12-21T19:03:51ZengSAGE PublishingTherapeutic Advances in Drug Safety2042-09942021-02-011210.1177/2042098620985690Routine use of immunosuppressants is associated with mortality in hospitalised patients with COVID-19Phyo K. MyintBen CarterFenella Barlow-PayRoxanna ShortAlice G. EinarssonEilidh BruceKathryn McCarthyAlessia VerduriJemima CollinsJames HesfordFrances RickardEmma MitchellMark HollowayAine McGovernArturo Vilches-MoragaPhilip BraudeLyndsay PearceMichael StechmanAngeline PriceTerence J. QuinnEnrico CliniSusan MougJonathan HewittBackground: Whilst there is literature on the impact of SARS viruses in the severely immunosuppressed, less is known about the link between routine immunosuppressant use and outcome in COVID-19. Consequently, guidelines on their use vary depending on specific patient populations. Methods: The study population was drawn from the COPE Study (COVID-19 in Older People), a multicentre observational cohort study, across the UK and Italy. Data were collected between 27 February and 28 April 2020 by trained data-collectors and included all unselected consecutive admissions with COVID-19. Load (name/number of medications) and dosage of immunosuppressant were collected along with other covariate data. Primary outcome was time-to-mortality from the date of admission (or) date of diagnosis, if diagnosis was five or more days after admission. Secondary outcomes were Day-14 mortality and time-to-discharge. Data were analysed with mixed-effects, Cox proportional hazards and logistic regression models using non-users of immunosuppressants as the reference group. Results: In total 1184 patients were eligible for inclusion. The median (IQR) age was 74 (62–83), 676 (57%) were male, and 299 (25.3%) died in hospital (total person follow-up 15,540 days). Most patients exhibited at least one comorbidity, and 113 (~10%) were on immunosuppressants. Any immunosuppressant use was associated with increased mortality: aHR 1.87, 95% CI: 1.30, 2.69 (time to mortality) and aOR 1.71, 95% CI: 1.01–2.88 (14-day mortality). There also appeared to be a dose–response relationship. Conclusion: Despite possible indication bias, until further evidence emerges we recommend adhering to public health measures, a low threshold to seek medical advice and close monitoring of symptoms in those who take immunosuppressants routinely regardless of their indication. However, it should be noted that the inability to control for the underlying condition requiring immunosuppressants is a major limitation, and hence caution should be exercised in interpretation of the results. Plain Language Summary Regular Use of Immune Suppressing Drugs is Associated with Increased Risk of Death in Hospitalised Patients with COVID-19 Background: We do not have much information on how the COVID-19 virus affects patients who use immunosuppressants, drugs which inhibit or reduce the activity of the immune system. There are various conflicting views on whether immune-suppressing drugs are beneficial or detrimental in patients with the disease. Methods: This study collected data from 10 hospitals in the UK and one in Italy between February and April 2020 in order to identify any association between the regular use of immunosuppressant medicines and survival in patients who were admitted to hospital with COVID-19. Results: 1184 patients were included in the study, and 10% of them were using immunosuppressants. Any immunosuppressant use was associated with increased risk of death, and the risk appeared to increase if the dose of the medicine was higher. Conclusion: We therefore recommend that patients who take immunosuppressant medicines routinely should carefully adhere to social distancing measures, and seek medical attention early during the COVID-19 pandemic.https://doi.org/10.1177/2042098620985690 |
| spellingShingle | Phyo K. Myint Ben Carter Fenella Barlow-Pay Roxanna Short Alice G. Einarsson Eilidh Bruce Kathryn McCarthy Alessia Verduri Jemima Collins James Hesford Frances Rickard Emma Mitchell Mark Holloway Aine McGovern Arturo Vilches-Moraga Philip Braude Lyndsay Pearce Michael Stechman Angeline Price Terence J. Quinn Enrico Clini Susan Moug Jonathan Hewitt Routine use of immunosuppressants is associated with mortality in hospitalised patients with COVID-19 Therapeutic Advances in Drug Safety |
| title | Routine use of immunosuppressants is associated with mortality in hospitalised patients with COVID-19 |
| title_full | Routine use of immunosuppressants is associated with mortality in hospitalised patients with COVID-19 |
| title_fullStr | Routine use of immunosuppressants is associated with mortality in hospitalised patients with COVID-19 |
| title_full_unstemmed | Routine use of immunosuppressants is associated with mortality in hospitalised patients with COVID-19 |
| title_short | Routine use of immunosuppressants is associated with mortality in hospitalised patients with COVID-19 |
| title_sort | routine use of immunosuppressants is associated with mortality in hospitalised patients with covid 19 |
| url | https://doi.org/10.1177/2042098620985690 |
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