Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma
Many cancer immune therapy approaches depend on an HLA-restricted neoantigen-specific T cell response. AUs show here that Zoledronic acid can expand, and induce tumour recognition by, a population of tissue resident memory gamma-delta T cells associated with an efficient anti-tumour immune response...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29012-1 |
| _version_ | 1828916203467309056 |
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| author | Nekisa Zakeri Andrew Hall Leo Swadling Laura J. Pallett Nathalie M. Schmidt Mariana O. Diniz Stephanie Kucykowicz Oliver E. Amin Amir Gander Massimo Pinzani Brian R. Davidson Alberto Quaglia Mala K. Maini |
| author_facet | Nekisa Zakeri Andrew Hall Leo Swadling Laura J. Pallett Nathalie M. Schmidt Mariana O. Diniz Stephanie Kucykowicz Oliver E. Amin Amir Gander Massimo Pinzani Brian R. Davidson Alberto Quaglia Mala K. Maini |
| author_sort | Nekisa Zakeri |
| collection | DOAJ |
| description | Many cancer immune therapy approaches depend on an HLA-restricted neoantigen-specific T cell response. AUs show here that Zoledronic acid can expand, and induce tumour recognition by, a population of tissue resident memory gamma-delta T cells associated with an efficient anti-tumour immune response in hepatocellular carcinoma. |
| first_indexed | 2024-12-13T20:28:13Z |
| format | Article |
| id | doaj.art-0e7c092920294bfe9e9bbd52f4f15461 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T20:28:13Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0e7c092920294bfe9e9bbd52f4f154612022-12-21T23:32:30ZengNature PortfolioNature Communications2041-17232022-03-0113111610.1038/s41467-022-29012-1Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinomaNekisa Zakeri0Andrew Hall1Leo Swadling2Laura J. Pallett3Nathalie M. Schmidt4Mariana O. Diniz5Stephanie Kucykowicz6Oliver E. Amin7Amir Gander8Massimo Pinzani9Brian R. Davidson10Alberto Quaglia11Mala K. Maini12Division of Infection & Immunity, Institute of Immunity & Transplantation, University College LondonInstitute for Liver & Digestive Health, Royal Free London NHS Foundation TrustDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College LondonDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College LondonDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College LondonDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College LondonDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College LondonDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College LondonDivision of Surgery, University College LondonInstitute for Liver & Digestive Health, Royal Free London NHS Foundation TrustDivision of Surgery, University College LondonDepartment of Cellular Pathology, Royal Free London NHS Foundation Trust and UCL Cancer InstituteDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College LondonMany cancer immune therapy approaches depend on an HLA-restricted neoantigen-specific T cell response. AUs show here that Zoledronic acid can expand, and induce tumour recognition by, a population of tissue resident memory gamma-delta T cells associated with an efficient anti-tumour immune response in hepatocellular carcinoma.https://doi.org/10.1038/s41467-022-29012-1 |
| spellingShingle | Nekisa Zakeri Andrew Hall Leo Swadling Laura J. Pallett Nathalie M. Schmidt Mariana O. Diniz Stephanie Kucykowicz Oliver E. Amin Amir Gander Massimo Pinzani Brian R. Davidson Alberto Quaglia Mala K. Maini Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma Nature Communications |
| title | Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma |
| title_full | Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma |
| title_fullStr | Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma |
| title_full_unstemmed | Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma |
| title_short | Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma |
| title_sort | characterisation and induction of tissue resident gamma delta t cells to target hepatocellular carcinoma |
| url | https://doi.org/10.1038/s41467-022-29012-1 |
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