Endoscopic and Histopathological Findings of the Esophagus, Stomach, and Duodenum in Patients with Crohn’s Disease from a Reference Center in Bahia, Brazil
(1) The aim of the present study was to describe the endoscopic and histopathological findings in the esophagus, stomach, and duodenum in patients with Crohn’s disease. (2) Methods: This was a cross-sectional study that included patients receiving treatment from the inflammatory bowel disease outpat...
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MDPI AG
2021-06-01
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| Series: | Clinics and Practice |
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| Online Access: | https://www.mdpi.com/2039-7283/11/2/52 |
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| author | Andrea Maia Pimentel Luiz Antônio Rodrigues de Freitas Rita de Cássia Reis Cruz Isaac Neri de Novais Silva Laíla Damasceno Andrade Paola Nascimento Marques Júlia Cordeiro Braga Flora Maria Lorenzo Fortes Katia Rejane Marques Brito Jaciane Araújo Mota Fontes Neogélia Pereira Almeida Valdiana Cristina Surlo Raquel Rocha André Castro Lyra Genoile Oliveira Santana |
| author_facet | Andrea Maia Pimentel Luiz Antônio Rodrigues de Freitas Rita de Cássia Reis Cruz Isaac Neri de Novais Silva Laíla Damasceno Andrade Paola Nascimento Marques Júlia Cordeiro Braga Flora Maria Lorenzo Fortes Katia Rejane Marques Brito Jaciane Araújo Mota Fontes Neogélia Pereira Almeida Valdiana Cristina Surlo Raquel Rocha André Castro Lyra Genoile Oliveira Santana |
| author_sort | Andrea Maia Pimentel |
| collection | DOAJ |
| description | (1) The aim of the present study was to describe the endoscopic and histopathological findings in the esophagus, stomach, and duodenum in patients with Crohn’s disease. (2) Methods: This was a cross-sectional study that included patients receiving treatment from the inflammatory bowel disease outpatient clinic. Esophagogastroduodenoscopies with biopsies of the stomach and proximal duodenum were performed. Presence of <i>Helicobacter pylori</i> bacteria was assessed by Giemsa staining. (3) Results: We included 58 patients. Erosive esophagitis was identified in 25 patients (43.1%), gastritis was diagnosed in 32 patients (55.2%) and erosive duodenitis was found in eight (13.8%). The most frequent histopathological finding in the <i>H. pylori</i>-positive group was increased inflammatory activity in the gastric body and antrum, with a predominance of mononuclear and polymorphonuclear cells. In turn, the most frequent finding in the <i>H. pylori</i>-negative group was chronic inflammation with predominance of mononuclear cells. Focally enhanced gastritis was identified in four patients (6.9%), all of whom were negative for <i>H. pylori</i>. Granulomas were not observed. <i>H. pylori</i> infection was present in 19 patients (32.8%). (4) Conclusions: Nonspecific endoscopic and histological findings were frequent in patients with Crohn’s disease. Focally enhanced gastritis was uncommon and observed only in <i>H. pylori-</i>negative patients. The time from the diagnosis, patient age, and therapy in use may have influenced the nondetection of epithelioid granuloma. |
| first_indexed | 2024-03-10T10:24:03Z |
| format | Article |
| id | doaj.art-0e7c1a8324264ca7ba2988b962a2482f |
| institution | Directory Open Access Journal |
| issn | 2039-7283 |
| language | English |
| last_indexed | 2024-03-10T10:24:03Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj.art-0e7c1a8324264ca7ba2988b962a2482f2023-11-22T00:07:34ZengMDPI AGClinics and Practice2039-72832021-06-0111237438510.3390/clinpract11020052Endoscopic and Histopathological Findings of the Esophagus, Stomach, and Duodenum in Patients with Crohn’s Disease from a Reference Center in Bahia, BrazilAndrea Maia Pimentel0Luiz Antônio Rodrigues de Freitas1Rita de Cássia Reis Cruz2Isaac Neri de Novais Silva3Laíla Damasceno Andrade4Paola Nascimento Marques5Júlia Cordeiro Braga6Flora Maria Lorenzo Fortes7Katia Rejane Marques Brito8Jaciane Araújo Mota Fontes9Neogélia Pereira Almeida10Valdiana Cristina Surlo11Raquel Rocha12André Castro Lyra13Genoile Oliveira Santana14Medicine and Health Science Postgraduate Program, Federal University of Bahia, Salvador 40026-010, BrazilPathology Laboratory, Gonçalo Moniz Institute Fiocruz Bahia, Salvador 40296-710, BrazilGastroenterology Unit, Hospital Geral Roberto Santos, Salvador 45675-000, BrazilDepartment of Life Sciences, Universidade do Estado da Bahia, Salvador 41195-001, BrazilMedical School, Centro Universitário UniFTC, Salvador 41741-590, BrazilDepartment of Life Sciences, Universidade do Estado da Bahia, Salvador 41195-001, BrazilDepartment of Life Sciences, Universidade do Estado da Bahia, Salvador 41195-001, BrazilGastroenterology Unit, Hospital Geral Roberto Santos, Salvador 45675-000, BrazilGastroenterology Unit, Hospital Geral Roberto Santos, Salvador 45675-000, BrazilGastroenterology Unit, Hospital Geral Roberto Santos, Salvador 45675-000, BrazilGastroenterology Unit, Hospital Geral Roberto Santos, Salvador 45675-000, BrazilGastroenterology Unit, Hospital Geral Roberto Santos, Salvador 45675-000, BrazilDepartment of Sciences of Nutrition, School of Nutrition, Federal University of Bahia, Salvador 41195-00, BrazilMedicine and Health Science Postgraduate Program, Federal University of Bahia, Salvador 40026-010, BrazilMedicine and Health Science Postgraduate Program, Federal University of Bahia, Salvador 40026-010, Brazil(1) The aim of the present study was to describe the endoscopic and histopathological findings in the esophagus, stomach, and duodenum in patients with Crohn’s disease. (2) Methods: This was a cross-sectional study that included patients receiving treatment from the inflammatory bowel disease outpatient clinic. Esophagogastroduodenoscopies with biopsies of the stomach and proximal duodenum were performed. Presence of <i>Helicobacter pylori</i> bacteria was assessed by Giemsa staining. (3) Results: We included 58 patients. Erosive esophagitis was identified in 25 patients (43.1%), gastritis was diagnosed in 32 patients (55.2%) and erosive duodenitis was found in eight (13.8%). The most frequent histopathological finding in the <i>H. pylori</i>-positive group was increased inflammatory activity in the gastric body and antrum, with a predominance of mononuclear and polymorphonuclear cells. In turn, the most frequent finding in the <i>H. pylori</i>-negative group was chronic inflammation with predominance of mononuclear cells. Focally enhanced gastritis was identified in four patients (6.9%), all of whom were negative for <i>H. pylori</i>. Granulomas were not observed. <i>H. pylori</i> infection was present in 19 patients (32.8%). (4) Conclusions: Nonspecific endoscopic and histological findings were frequent in patients with Crohn’s disease. Focally enhanced gastritis was uncommon and observed only in <i>H. pylori-</i>negative patients. The time from the diagnosis, patient age, and therapy in use may have influenced the nondetection of epithelioid granuloma.https://www.mdpi.com/2039-7283/11/2/52Crohn’s diseasegastritisenhanced focally gastritisgranuloma<i>Helicobacter pylori</i> |
| spellingShingle | Andrea Maia Pimentel Luiz Antônio Rodrigues de Freitas Rita de Cássia Reis Cruz Isaac Neri de Novais Silva Laíla Damasceno Andrade Paola Nascimento Marques Júlia Cordeiro Braga Flora Maria Lorenzo Fortes Katia Rejane Marques Brito Jaciane Araújo Mota Fontes Neogélia Pereira Almeida Valdiana Cristina Surlo Raquel Rocha André Castro Lyra Genoile Oliveira Santana Endoscopic and Histopathological Findings of the Esophagus, Stomach, and Duodenum in Patients with Crohn’s Disease from a Reference Center in Bahia, Brazil Clinics and Practice Crohn’s disease gastritis enhanced focally gastritis granuloma <i>Helicobacter pylori</i> |
| title | Endoscopic and Histopathological Findings of the Esophagus, Stomach, and Duodenum in Patients with Crohn’s Disease from a Reference Center in Bahia, Brazil |
| title_full | Endoscopic and Histopathological Findings of the Esophagus, Stomach, and Duodenum in Patients with Crohn’s Disease from a Reference Center in Bahia, Brazil |
| title_fullStr | Endoscopic and Histopathological Findings of the Esophagus, Stomach, and Duodenum in Patients with Crohn’s Disease from a Reference Center in Bahia, Brazil |
| title_full_unstemmed | Endoscopic and Histopathological Findings of the Esophagus, Stomach, and Duodenum in Patients with Crohn’s Disease from a Reference Center in Bahia, Brazil |
| title_short | Endoscopic and Histopathological Findings of the Esophagus, Stomach, and Duodenum in Patients with Crohn’s Disease from a Reference Center in Bahia, Brazil |
| title_sort | endoscopic and histopathological findings of the esophagus stomach and duodenum in patients with crohn s disease from a reference center in bahia brazil |
| topic | Crohn’s disease gastritis enhanced focally gastritis granuloma <i>Helicobacter pylori</i> |
| url | https://www.mdpi.com/2039-7283/11/2/52 |
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