Oxidative homeostasis in follicular fluid and reproductive outcomes – from bench to bedside
Free radicals and oxidant molecules are part of our organism in a stable balance. However, when addressing female infertility, questions about their role in oocyte quality arise. This review outlines the major alterations of redox homeostasis in the follicular fluid through pathophysiological condit...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2022-12-01
|
| Series: | Menopause Review |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Oxidative-homeostasis-in-follicular-fluid-and-reproductive-outcomes-from-bench-to-bedside,4,49875,1,1.html |
| _version_ | 1797943349669265408 |
|---|---|
| author | Ivana Zec Marina Šprem Goldštajn Krunoslav Kuna Mislav Mikuš Guglielmo Stabile Bianca Bianco Giovanni Buzzaccarini Antonio Simone Laganà |
| author_facet | Ivana Zec Marina Šprem Goldštajn Krunoslav Kuna Mislav Mikuš Guglielmo Stabile Bianca Bianco Giovanni Buzzaccarini Antonio Simone Laganà |
| author_sort | Ivana Zec |
| collection | DOAJ |
| description | Free radicals and oxidant molecules are part of our organism in a stable balance. However, when addressing female infertility, questions about their role in oocyte quality arise. This review outlines the major alterations of redox homeostasis in the follicular fluid through pathophysiological conditions in female reproduction and its potential effect on IVF outcome. A review of the literature was accurately performed. Manuscripts investigating follicular fluid biomarkers, especially related to oxidant molecules, were screened and used in this review. Studies assessing the follicular reactive species were found and screened. Moreover, studies assessing the IVF outcomes related to biomarkers were considered. The results are provided in an analytical pathway. The study of biomarkers confirms the shift to enhanced oxidizing modification of macromolecules and antioxidative consumption in the follicular fluid of women undergoing IVF treatment. A lack of congruency in methods appears to be marked in the design of scientific studies. However, it is not clear whether redox disbalance has a disruptive effect on the oocyte competence or whether it plays a role in the oocyte maturation process. Red-ox balance plays a questionable role in IVF outcomes. Possible further insights may consider the antioxidant role of adjuvants during controlled ovarian stimulation cycles. |
| first_indexed | 2024-04-10T20:22:47Z |
| format | Article |
| id | doaj.art-0e7d9e07b1fd43babc34a3bb4dba5deb |
| institution | Directory Open Access Journal |
| issn | 1643-8876 2299-0038 |
| language | English |
| last_indexed | 2024-04-10T20:22:47Z |
| publishDate | 2022-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Menopause Review |
| spelling | doaj.art-0e7d9e07b1fd43babc34a3bb4dba5deb2023-01-25T13:45:57ZengTermedia Publishing HouseMenopause Review1643-88762299-00382022-12-0121427628410.5114/pm.2022.12401949875Oxidative homeostasis in follicular fluid and reproductive outcomes – from bench to bedsideIvana ZecMarina Šprem GoldštajnKrunoslav KunaMislav MikušGuglielmo StabileBianca BiancoGiovanni BuzzaccariniAntonio Simone LaganàFree radicals and oxidant molecules are part of our organism in a stable balance. However, when addressing female infertility, questions about their role in oocyte quality arise. This review outlines the major alterations of redox homeostasis in the follicular fluid through pathophysiological conditions in female reproduction and its potential effect on IVF outcome. A review of the literature was accurately performed. Manuscripts investigating follicular fluid biomarkers, especially related to oxidant molecules, were screened and used in this review. Studies assessing the follicular reactive species were found and screened. Moreover, studies assessing the IVF outcomes related to biomarkers were considered. The results are provided in an analytical pathway. The study of biomarkers confirms the shift to enhanced oxidizing modification of macromolecules and antioxidative consumption in the follicular fluid of women undergoing IVF treatment. A lack of congruency in methods appears to be marked in the design of scientific studies. However, it is not clear whether redox disbalance has a disruptive effect on the oocyte competence or whether it plays a role in the oocyte maturation process. Red-ox balance plays a questionable role in IVF outcomes. Possible further insights may consider the antioxidant role of adjuvants during controlled ovarian stimulation cycles.https://www.termedia.pl/Oxidative-homeostasis-in-follicular-fluid-and-reproductive-outcomes-from-bench-to-bedside,4,49875,1,1.htmlreactive-oxygen species follicular fluid oxidant in vitro fertilization assisted reproductive techniques. |
| spellingShingle | Ivana Zec Marina Šprem Goldštajn Krunoslav Kuna Mislav Mikuš Guglielmo Stabile Bianca Bianco Giovanni Buzzaccarini Antonio Simone Laganà Oxidative homeostasis in follicular fluid and reproductive outcomes – from bench to bedside Menopause Review reactive-oxygen species follicular fluid oxidant in vitro fertilization assisted reproductive techniques. |
| title | Oxidative homeostasis in follicular fluid and reproductive outcomes – from bench to bedside |
| title_full | Oxidative homeostasis in follicular fluid and reproductive outcomes – from bench to bedside |
| title_fullStr | Oxidative homeostasis in follicular fluid and reproductive outcomes – from bench to bedside |
| title_full_unstemmed | Oxidative homeostasis in follicular fluid and reproductive outcomes – from bench to bedside |
| title_short | Oxidative homeostasis in follicular fluid and reproductive outcomes – from bench to bedside |
| title_sort | oxidative homeostasis in follicular fluid and reproductive outcomes from bench to bedside |
| topic | reactive-oxygen species follicular fluid oxidant in vitro fertilization assisted reproductive techniques. |
| url | https://www.termedia.pl/Oxidative-homeostasis-in-follicular-fluid-and-reproductive-outcomes-from-bench-to-bedside,4,49875,1,1.html |
| work_keys_str_mv | AT ivanazec oxidativehomeostasisinfollicularfluidandreproductiveoutcomesfrombenchtobedside AT marinaspremgoldstajn oxidativehomeostasisinfollicularfluidandreproductiveoutcomesfrombenchtobedside AT krunoslavkuna oxidativehomeostasisinfollicularfluidandreproductiveoutcomesfrombenchtobedside AT mislavmikus oxidativehomeostasisinfollicularfluidandreproductiveoutcomesfrombenchtobedside AT guglielmostabile oxidativehomeostasisinfollicularfluidandreproductiveoutcomesfrombenchtobedside AT biancabianco oxidativehomeostasisinfollicularfluidandreproductiveoutcomesfrombenchtobedside AT giovannibuzzaccarini oxidativehomeostasisinfollicularfluidandreproductiveoutcomesfrombenchtobedside AT antoniosimonelagana oxidativehomeostasisinfollicularfluidandreproductiveoutcomesfrombenchtobedside |