Programmable High Integration and Resolution Digital Microfluidic Device Driven by Thin Film Transistor Arrays
A digital microfluidic (DMF) system based on electrowetting on dielectrics (EWOD) is a new technology that is able to manipulate microlitre droplets on the plane. Conventional EWOD devices have difficulty achieving high integration and a large number of electrodes due to the limitation of electrical...
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| Format: | Article |
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IEEE
2022-01-01
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| Series: | IEEE Access |
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| Online Access: | https://ieeexplore.ieee.org/document/9736447/ |
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| author | Zhijie Luo Jiazhi Xu Zhongyu Pan Hang Yin Liang Cao Guofu Zhou Shuangyin Liu |
| author_facet | Zhijie Luo Jiazhi Xu Zhongyu Pan Hang Yin Liang Cao Guofu Zhou Shuangyin Liu |
| author_sort | Zhijie Luo |
| collection | DOAJ |
| description | A digital microfluidic (DMF) system based on electrowetting on dielectrics (EWOD) is a new technology that is able to manipulate microlitre droplets on the plane. Conventional EWOD devices have difficulty achieving high integration and a large number of electrodes due to the limitation of electrical connections. To realize the precise control of multiple droplets in a large-area EWOD device, we propose a programmable high integration and resolution DMF device based on a thin film transistor array (TFTA) – EWOD in this paper. The TFTA backplane with thousands of individually addressable electrodes used in electrowetting displays (EWDs) is integrated into this device. A source integrated circuit (IC) and a gate IC are bonded on the substrate glass of the device as the driver chip. A TFTA-EWOD device with <inline-formula> <tex-math notation="LaTeX">$\mathrm {320 \times 240}$ </tex-math></inline-formula> electrodes is designed, fabricated and tested in our experiments. Furthermore, a matching droplet control system with detection and feedback functions was developed and implemented. This system is capable of detecting and analysing individual droplet status while concurrently continuing with other droplet manipulations on the TFTA-EWOD device. The experimental results show that different droplet manipulations, including dispensing, merging and transport, can be carried out successfully on this device. We also successfully applied the proposed device and system to a colorimetric enzymatic assay to show that the proposed scheme is capable of chemical analysis experiments. There are no additional errors introduced by the proposed TFTA-EWOD device. The designed device and matching system proposes a programmable high integration, high resolution, and universal solution for complex DMF applications. We hope that the proposed device and system can provide an experimental platform to other research teams who focus on DMF applications. |
| first_indexed | 2024-12-13T09:34:32Z |
| format | Article |
| id | doaj.art-0e7fc37bca09400592e5c7ac78f55b44 |
| institution | Directory Open Access Journal |
| issn | 2169-3536 |
| language | English |
| last_indexed | 2024-12-13T09:34:32Z |
| publishDate | 2022-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Access |
| spelling | doaj.art-0e7fc37bca09400592e5c7ac78f55b442022-12-21T23:52:23ZengIEEEIEEE Access2169-35362022-01-0110305733058210.1109/ACCESS.2022.31592439736447Programmable High Integration and Resolution Digital Microfluidic Device Driven by Thin Film Transistor ArraysZhijie Luo0https://orcid.org/0000-0001-8541-965XJiazhi Xu1Zhongyu Pan2Hang Yin3https://orcid.org/0000-0003-4605-8008Liang Cao4Guofu Zhou5Shuangyin Liu6College of Information Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, ChinaCollege of Information Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, ChinaCollege of Information Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, ChinaCollege of Information Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, ChinaCollege of Information Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, ChinaInstitute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou, ChinaCollege of Information Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, ChinaA digital microfluidic (DMF) system based on electrowetting on dielectrics (EWOD) is a new technology that is able to manipulate microlitre droplets on the plane. Conventional EWOD devices have difficulty achieving high integration and a large number of electrodes due to the limitation of electrical connections. To realize the precise control of multiple droplets in a large-area EWOD device, we propose a programmable high integration and resolution DMF device based on a thin film transistor array (TFTA) – EWOD in this paper. The TFTA backplane with thousands of individually addressable electrodes used in electrowetting displays (EWDs) is integrated into this device. A source integrated circuit (IC) and a gate IC are bonded on the substrate glass of the device as the driver chip. A TFTA-EWOD device with <inline-formula> <tex-math notation="LaTeX">$\mathrm {320 \times 240}$ </tex-math></inline-formula> electrodes is designed, fabricated and tested in our experiments. Furthermore, a matching droplet control system with detection and feedback functions was developed and implemented. This system is capable of detecting and analysing individual droplet status while concurrently continuing with other droplet manipulations on the TFTA-EWOD device. The experimental results show that different droplet manipulations, including dispensing, merging and transport, can be carried out successfully on this device. We also successfully applied the proposed device and system to a colorimetric enzymatic assay to show that the proposed scheme is capable of chemical analysis experiments. There are no additional errors introduced by the proposed TFTA-EWOD device. The designed device and matching system proposes a programmable high integration, high resolution, and universal solution for complex DMF applications. We hope that the proposed device and system can provide an experimental platform to other research teams who focus on DMF applications.https://ieeexplore.ieee.org/document/9736447/Electrowetting on dielectricdigital microfluidicthin film transistor arrayintegration |
| spellingShingle | Zhijie Luo Jiazhi Xu Zhongyu Pan Hang Yin Liang Cao Guofu Zhou Shuangyin Liu Programmable High Integration and Resolution Digital Microfluidic Device Driven by Thin Film Transistor Arrays IEEE Access Electrowetting on dielectric digital microfluidic thin film transistor array integration |
| title | Programmable High Integration and Resolution Digital Microfluidic Device Driven by Thin Film Transistor Arrays |
| title_full | Programmable High Integration and Resolution Digital Microfluidic Device Driven by Thin Film Transistor Arrays |
| title_fullStr | Programmable High Integration and Resolution Digital Microfluidic Device Driven by Thin Film Transistor Arrays |
| title_full_unstemmed | Programmable High Integration and Resolution Digital Microfluidic Device Driven by Thin Film Transistor Arrays |
| title_short | Programmable High Integration and Resolution Digital Microfluidic Device Driven by Thin Film Transistor Arrays |
| title_sort | programmable high integration and resolution digital microfluidic device driven by thin film transistor arrays |
| topic | Electrowetting on dielectric digital microfluidic thin film transistor array integration |
| url | https://ieeexplore.ieee.org/document/9736447/ |
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