The worldwide burden of HIV in transgender individuals: An updated systematic review and meta-analysis.
<h4>Introduction</h4>Transgender individuals are at risk for HIV. HIV risks are dynamic and there have been substantial changes in HIV prevention (e.g., pre-exposure prophylaxis [PrEP]). It is thus time to revisit HIV prevalence and burden among transgender individuals. The objective of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0260063 |
| _version_ | 1819283619860971520 |
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| author | Sarah E Stutterheim Mart van Dijk Haoyi Wang Kai J Jonas |
| author_facet | Sarah E Stutterheim Mart van Dijk Haoyi Wang Kai J Jonas |
| author_sort | Sarah E Stutterheim |
| collection | DOAJ |
| description | <h4>Introduction</h4>Transgender individuals are at risk for HIV. HIV risks are dynamic and there have been substantial changes in HIV prevention (e.g., pre-exposure prophylaxis [PrEP]). It is thus time to revisit HIV prevalence and burden among transgender individuals. The objective of this systematic review and meta-analysis was thus to examine worldwide prevalence and burden of HIV over the course of the epidemic among trans feminine and trans masculine individuals.<h4>Methods</h4>We conducted an updated systematic review by searching PsycINFO, PubMed, Web of Science, and Google Scholar, for studies of any research design published in in a peer-reviewed journal in any language that reported HIV prevalence among transgender individuals published between January 2000 and January 2019. Two independent reviewers extracted the data and assessed methodological quality. We then conducted a meta-analysis, using random-effects modelling, to ascertain standardized prevalence and the relative burden of HIV carried by transgender individuals by country and year of data collection, and then by geographic region. We additionally explored the impact of sampling methods and pre-exposure prophylaxis (PrEP).<h4>Results</h4>Based on 98 studies, overall standardized HIV prevalence over the course of the epidemic, based on weights from each country by year, was 19.9% (95% CI 14.7% - 25.1%) for trans feminine individuals (n = 48,604) and 2.56% (95% CI 0.0% - 5.9%) for trans masculine individuals (n = 6460). Overall OR for HIV infection, compared with individuals over age 15, was 66.0 (95% CI 51.4-84.8) for trans feminine individuals and 6.8 (95% CI 3.6-13.1) for trans masculine individuals. Prevalence varied by geographic region (13.5% - 29.9%) and sampling method (5.4% - 37.8%). Lastly, PrEP effects on prevalence could not be established.<h4>Conclusion</h4>Trans feminine and trans masculine individuals are disproportionately burdened by HIV. Their unique prevention and care needs should be comprehensively addressed. Future research should further investigate the impact of sampling methods on HIV prevalence, and monitor the potential impact of PrEP. |
| first_indexed | 2024-12-24T01:34:22Z |
| format | Article |
| id | doaj.art-0e7fe377340244659fe1c7865b89d757 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-24T01:34:22Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0e7fe377340244659fe1c7865b89d7572022-12-21T17:22:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011612e026006310.1371/journal.pone.0260063The worldwide burden of HIV in transgender individuals: An updated systematic review and meta-analysis.Sarah E StutterheimMart van DijkHaoyi WangKai J Jonas<h4>Introduction</h4>Transgender individuals are at risk for HIV. HIV risks are dynamic and there have been substantial changes in HIV prevention (e.g., pre-exposure prophylaxis [PrEP]). It is thus time to revisit HIV prevalence and burden among transgender individuals. The objective of this systematic review and meta-analysis was thus to examine worldwide prevalence and burden of HIV over the course of the epidemic among trans feminine and trans masculine individuals.<h4>Methods</h4>We conducted an updated systematic review by searching PsycINFO, PubMed, Web of Science, and Google Scholar, for studies of any research design published in in a peer-reviewed journal in any language that reported HIV prevalence among transgender individuals published between January 2000 and January 2019. Two independent reviewers extracted the data and assessed methodological quality. We then conducted a meta-analysis, using random-effects modelling, to ascertain standardized prevalence and the relative burden of HIV carried by transgender individuals by country and year of data collection, and then by geographic region. We additionally explored the impact of sampling methods and pre-exposure prophylaxis (PrEP).<h4>Results</h4>Based on 98 studies, overall standardized HIV prevalence over the course of the epidemic, based on weights from each country by year, was 19.9% (95% CI 14.7% - 25.1%) for trans feminine individuals (n = 48,604) and 2.56% (95% CI 0.0% - 5.9%) for trans masculine individuals (n = 6460). Overall OR for HIV infection, compared with individuals over age 15, was 66.0 (95% CI 51.4-84.8) for trans feminine individuals and 6.8 (95% CI 3.6-13.1) for trans masculine individuals. Prevalence varied by geographic region (13.5% - 29.9%) and sampling method (5.4% - 37.8%). Lastly, PrEP effects on prevalence could not be established.<h4>Conclusion</h4>Trans feminine and trans masculine individuals are disproportionately burdened by HIV. Their unique prevention and care needs should be comprehensively addressed. Future research should further investigate the impact of sampling methods on HIV prevalence, and monitor the potential impact of PrEP.https://doi.org/10.1371/journal.pone.0260063 |
| spellingShingle | Sarah E Stutterheim Mart van Dijk Haoyi Wang Kai J Jonas The worldwide burden of HIV in transgender individuals: An updated systematic review and meta-analysis. PLoS ONE |
| title | The worldwide burden of HIV in transgender individuals: An updated systematic review and meta-analysis. |
| title_full | The worldwide burden of HIV in transgender individuals: An updated systematic review and meta-analysis. |
| title_fullStr | The worldwide burden of HIV in transgender individuals: An updated systematic review and meta-analysis. |
| title_full_unstemmed | The worldwide burden of HIV in transgender individuals: An updated systematic review and meta-analysis. |
| title_short | The worldwide burden of HIV in transgender individuals: An updated systematic review and meta-analysis. |
| title_sort | worldwide burden of hiv in transgender individuals an updated systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0260063 |
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