Prolonged voluntary wheel running reveals unique adaptations in mdx mice treated with microdystrophin constructs ± the nNOS-binding site

Prolonged voluntary wheel running reveals unique adaptations in mdx mice treated with microdystrophin constructs ± the nNOS-binding site

We tested the effects of prolonged voluntary wheel running on the muscle function of mdx mice treated with one of two different microdystrophin constructs. At 7 weeks of age mdx mice were injected with a single dose of AAV9-CK8-microdystrophin with (gene therapy 1, GT1) or without (gene therapy 2, G...

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Bibliographic Details
Main Authors: S. E. Hamm, C. Yuan, L. F. McQueen, M. A. Wallace, H. Zhang, A. Arora, A. M. Garafalo, R. P. McMillan, M. W. Lawlor, M. J. Prom, E. M. Ott, J. Yan, A. K. Addington, C. A. Morris, J. P. Gonzalez, R. W. Grange
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Physiology
Subjects:
endurance
muscle strength
AAV (adeno-associated virus)
microdystrophin
longevity
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1166206/full

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