A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers
Introduction: Several recent studies pointed out that chromodomain-helicase-DNA-binding protein 1-like (CHD1L) is a putative oncogene in many human tumors. However, up to date, there is no pan-cancer analysis performed to study the different aspects of this gene expression and behavior in tumor tiss...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1017148/full |
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| author | Mohamed A. Soltan Muhammad Alaa Eldeen Refaat A. Eid Najiah M. Alyamani Leena S. Alqahtani Sarah Albogami Ibrahim Jafri Moon Nyeo Park Ghadi Alsharif Eman Fayad Gamal Mohamed Rihab Osman Bonglee Kim Mohamed Samir A. Zaki Mohamed Samir A. Zaki |
| author_facet | Mohamed A. Soltan Muhammad Alaa Eldeen Refaat A. Eid Najiah M. Alyamani Leena S. Alqahtani Sarah Albogami Ibrahim Jafri Moon Nyeo Park Ghadi Alsharif Eman Fayad Gamal Mohamed Rihab Osman Bonglee Kim Mohamed Samir A. Zaki Mohamed Samir A. Zaki |
| author_sort | Mohamed A. Soltan |
| collection | DOAJ |
| description | Introduction: Several recent studies pointed out that chromodomain-helicase-DNA-binding protein 1-like (CHD1L) is a putative oncogene in many human tumors. However, up to date, there is no pan-cancer analysis performed to study the different aspects of this gene expression and behavior in tumor tissues.Methods: Here, we applied several bioinformatics tools to make a comprehensive analysis for CHD1L. Firstly we assessed the expression of CHD1L in several types of human tumors and tried to correlate that with the stage and grade of the analyzed tumors. Following that, we performed a survival analysis to study the correlation between CHD1L upregulation in tumors and the clinical outcome. Additionally, we investigated the mutation forms, the correlation with several immune cell infiltration, and the potential molecular mechanisms of CHD1L in the tumor tissue.Result and discussion: The results demonstrated that CHD1L is a highly expressed gene across several types of tumors and that was correlated with a poor prognosis for most cancer patients. Moreover, it was found that CHD1L affects the tumor immune microenvironment by influencing the infiltration level of several immune cells. Collectively, the current study provides a comprehensive overview of the oncogenic roles of CHD1L where our results nominate CHD1L as a potential prognostic biomarker and target for antitumor therapy development. |
| first_indexed | 2024-04-09T22:13:32Z |
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| id | doaj.art-0e80bc1d762b4f2a959f8596012ec049 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-09T22:13:32Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-0e80bc1d762b4f2a959f8596012ec0492023-03-23T05:19:50ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-03-011010.3389/fmolb.2023.10171481017148A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancersMohamed A. Soltan0Muhammad Alaa Eldeen1Refaat A. Eid2Najiah M. Alyamani3Leena S. Alqahtani4Sarah Albogami5Ibrahim Jafri6Moon Nyeo Park7Ghadi Alsharif8Eman Fayad9Gamal Mohamed10Rihab Osman11Bonglee Kim12Mohamed Samir A. Zaki13Mohamed Samir A. Zaki14Department of Microbiology and Immunology, Faculty of Pharmacy, Sinai University, Ismailia, EgyptCell Biology, Histology and Genetics Division, Zoology Department, Faculty of Science, Zagazig University, Zagazig, EgyptPathology Department, College of Medicine, King Khalid University, Abha, Saudi ArabiaDepartment of Biology, College of Science, University of Jeddah, Jeddah, Saudi ArabiaDepartment of Biochemistry, College of Science, University of Jeddah, Jeddah, Saudi ArabiaDepartment of Biotechnology, College of Sciences, Taif University, Taif, Saudi ArabiaDepartment of Biotechnology, College of Sciences, Taif University, Taif, Saudi ArabiaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, South KoreaCollege of Clinical Laboratory Sciences, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaDepartment of Biotechnology, College of Sciences, Taif University, Taif, Saudi ArabiaDepartment of Human Anatomy, Jazan University, Jazan, Kingdom of Saydi Arabia0Department of Anatomy, College of Medicine, King Khalid University, Abha, Saudi ArabiaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea1Anatomy Department, College of Medicine, King Khalid University, Abha, Saudi Arabia2Department of Histology and Cell Biology, College of Medicine, Zagazig University, Zagazig, EgyptIntroduction: Several recent studies pointed out that chromodomain-helicase-DNA-binding protein 1-like (CHD1L) is a putative oncogene in many human tumors. However, up to date, there is no pan-cancer analysis performed to study the different aspects of this gene expression and behavior in tumor tissues.Methods: Here, we applied several bioinformatics tools to make a comprehensive analysis for CHD1L. Firstly we assessed the expression of CHD1L in several types of human tumors and tried to correlate that with the stage and grade of the analyzed tumors. Following that, we performed a survival analysis to study the correlation between CHD1L upregulation in tumors and the clinical outcome. Additionally, we investigated the mutation forms, the correlation with several immune cell infiltration, and the potential molecular mechanisms of CHD1L in the tumor tissue.Result and discussion: The results demonstrated that CHD1L is a highly expressed gene across several types of tumors and that was correlated with a poor prognosis for most cancer patients. Moreover, it was found that CHD1L affects the tumor immune microenvironment by influencing the infiltration level of several immune cells. Collectively, the current study provides a comprehensive overview of the oncogenic roles of CHD1L where our results nominate CHD1L as a potential prognostic biomarker and target for antitumor therapy development.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1017148/fullCHD1Lpan-cancerdifferential expressionprognosistumor immunotherapybiomarker |
| spellingShingle | Mohamed A. Soltan Muhammad Alaa Eldeen Refaat A. Eid Najiah M. Alyamani Leena S. Alqahtani Sarah Albogami Ibrahim Jafri Moon Nyeo Park Ghadi Alsharif Eman Fayad Gamal Mohamed Rihab Osman Bonglee Kim Mohamed Samir A. Zaki Mohamed Samir A. Zaki A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers Frontiers in Molecular Biosciences CHD1L pan-cancer differential expression prognosis tumor immunotherapy biomarker |
| title | A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers |
| title_full | A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers |
| title_fullStr | A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers |
| title_full_unstemmed | A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers |
| title_short | A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers |
| title_sort | pan cancer analysis reveals chd1l as a prognostic and immunological biomarker in several human cancers |
| topic | CHD1L pan-cancer differential expression prognosis tumor immunotherapy biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1017148/full |
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