Oxytocin Administration Alleviates Acute but Not Chronic Leptin Resistance of Diet-Induced Obese Mice
Whereas leptin administration only has a negligible effect on the treatment of obesity, it has been demonstrated that its action can be improved by co-administration of leptin and one of its sensitizers. Considering that oxytocin treatment decreases body weight in obese animals and humans, we invest...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-12-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-0067/20/1/88 |
| _version_ | 1811235707710078976 |
|---|---|
| author | Mehdi Labyb Chloé Chrétien Aurélie Caillon Françoise Rohner-Jeanrenaud Jordi Altirriba |
| author_facet | Mehdi Labyb Chloé Chrétien Aurélie Caillon Françoise Rohner-Jeanrenaud Jordi Altirriba |
| author_sort | Mehdi Labyb |
| collection | DOAJ |
| description | Whereas leptin administration only has a negligible effect on the treatment of obesity, it has been demonstrated that its action can be improved by co-administration of leptin and one of its sensitizers. Considering that oxytocin treatment decreases body weight in obese animals and humans, we investigated the effects of oxytocin and leptin cotreatment. First, lean and diet-induced obese (DIO) mice were treated with oxytocin for 2 weeks and we measured the acute leptin response. Second, DIO mice were treated for 2 weeks with saline, oxytocin (50 μg/day), leptin (20 or 40 µg/day) or oxytocin plus leptin. Oxytocin pre-treatment restored a normal acute leptin response, decreasing food intake and body weight gain. Chronic continuous administration of oxytocin or leptin at 40 µg/day decreased body weight in the presence (leptin) or in the absence (oxytocin) of cumulative differences in food intake. Saline or leptin treatment at 20 µg/day had no impact on body weight. Oxytocin and leptin cotreatments had no additional effects compared with single treatments. These results point to the fact that chronic oxytocin treatment improves the acute, but not the chronic leptin response, suggesting that this treatment could be used to improve the short-term satiety effect of leptin. |
| first_indexed | 2024-04-12T11:56:37Z |
| format | Article |
| id | doaj.art-0e816965a9cb4d7ab84c0499d21dfb15 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T11:56:37Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0e816965a9cb4d7ab84c0499d21dfb152022-12-22T03:33:59ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-12-012018810.3390/ijms20010088ijms20010088Oxytocin Administration Alleviates Acute but Not Chronic Leptin Resistance of Diet-Induced Obese MiceMehdi Labyb0Chloé Chrétien1Aurélie Caillon2Françoise Rohner-Jeanrenaud3Jordi Altirriba4Laboratory of Metabolism, Department of Medicine Specialties, Faculty of Medicine, University of Geneva, CH1211 Geneva, SwitzerlandDepartment of Cell Physiology and Metabolism, Geneva Medical Centre, CH1211 Geneva, SwitzerlandLaboratory of Metabolism, Department of Medicine Specialties, Faculty of Medicine, University of Geneva, CH1211 Geneva, SwitzerlandLaboratory of Metabolism, Department of Medicine Specialties, Faculty of Medicine, University of Geneva, CH1211 Geneva, SwitzerlandLaboratory of Metabolism, Department of Medicine Specialties, Faculty of Medicine, University of Geneva, CH1211 Geneva, SwitzerlandWhereas leptin administration only has a negligible effect on the treatment of obesity, it has been demonstrated that its action can be improved by co-administration of leptin and one of its sensitizers. Considering that oxytocin treatment decreases body weight in obese animals and humans, we investigated the effects of oxytocin and leptin cotreatment. First, lean and diet-induced obese (DIO) mice were treated with oxytocin for 2 weeks and we measured the acute leptin response. Second, DIO mice were treated for 2 weeks with saline, oxytocin (50 μg/day), leptin (20 or 40 µg/day) or oxytocin plus leptin. Oxytocin pre-treatment restored a normal acute leptin response, decreasing food intake and body weight gain. Chronic continuous administration of oxytocin or leptin at 40 µg/day decreased body weight in the presence (leptin) or in the absence (oxytocin) of cumulative differences in food intake. Saline or leptin treatment at 20 µg/day had no impact on body weight. Oxytocin and leptin cotreatments had no additional effects compared with single treatments. These results point to the fact that chronic oxytocin treatment improves the acute, but not the chronic leptin response, suggesting that this treatment could be used to improve the short-term satiety effect of leptin.http://www.mdpi.com/1422-0067/20/1/88oxytocinleptinobesityfood intake |
| spellingShingle | Mehdi Labyb Chloé Chrétien Aurélie Caillon Françoise Rohner-Jeanrenaud Jordi Altirriba Oxytocin Administration Alleviates Acute but Not Chronic Leptin Resistance of Diet-Induced Obese Mice International Journal of Molecular Sciences oxytocin leptin obesity food intake |
| title | Oxytocin Administration Alleviates Acute but Not Chronic Leptin Resistance of Diet-Induced Obese Mice |
| title_full | Oxytocin Administration Alleviates Acute but Not Chronic Leptin Resistance of Diet-Induced Obese Mice |
| title_fullStr | Oxytocin Administration Alleviates Acute but Not Chronic Leptin Resistance of Diet-Induced Obese Mice |
| title_full_unstemmed | Oxytocin Administration Alleviates Acute but Not Chronic Leptin Resistance of Diet-Induced Obese Mice |
| title_short | Oxytocin Administration Alleviates Acute but Not Chronic Leptin Resistance of Diet-Induced Obese Mice |
| title_sort | oxytocin administration alleviates acute but not chronic leptin resistance of diet induced obese mice |
| topic | oxytocin leptin obesity food intake |
| url | http://www.mdpi.com/1422-0067/20/1/88 |
| work_keys_str_mv | AT mehdilabyb oxytocinadministrationalleviatesacutebutnotchronicleptinresistanceofdietinducedobesemice AT chloechretien oxytocinadministrationalleviatesacutebutnotchronicleptinresistanceofdietinducedobesemice AT aureliecaillon oxytocinadministrationalleviatesacutebutnotchronicleptinresistanceofdietinducedobesemice AT francoiserohnerjeanrenaud oxytocinadministrationalleviatesacutebutnotchronicleptinresistanceofdietinducedobesemice AT jordialtirriba oxytocinadministrationalleviatesacutebutnotchronicleptinresistanceofdietinducedobesemice |