Discovery of proangiogenic CD44+mesenchymal cancer stem cells in an acute myeloid leukemia patient’s bone marrow
Abstract Here, we report a unique acute myeloid leukemia (AML) bone marrow-derived mesenchymal stem cell (MSC) with both mesenchymal and endothelial potential, which we have named Mesenchymal Cancer Stem Cells (MCSCs). These MCSCs are CD90-CD13-CD44+ and differ from MSCs in isolation, expansion, dif...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-06-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13045-020-00899-x |
| _version_ | 1819182280471478272 |
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| author | Huynh Cao Jeffrey Xiao Mark E. Reeves Kimberly Payne Chien Shing Chen David J. Baylink Guido Marcucci Yi Xu |
| author_facet | Huynh Cao Jeffrey Xiao Mark E. Reeves Kimberly Payne Chien Shing Chen David J. Baylink Guido Marcucci Yi Xu |
| author_sort | Huynh Cao |
| collection | DOAJ |
| description | Abstract Here, we report a unique acute myeloid leukemia (AML) bone marrow-derived mesenchymal stem cell (MSC) with both mesenchymal and endothelial potential, which we have named Mesenchymal Cancer Stem Cells (MCSCs). These MCSCs are CD90-CD13-CD44+ and differ from MSCs in isolation, expansion, differentiation, immunophenotype, and cytokine release profile. Furthermore, blocking CD44 inhibited the proliferation and cluster formation of early MCSCs with lower ICAM-1 protein levels. Similar CD90-CD44+ cancer stem cells have been reported in both gastric and breast cancers, which grew in floating spheres in vitro and exhibited mesenchymal features and high metastatic/tumorigenic capabilities in vivo. Our novel discovery provides the first evidence that certain AMLs may be comprised of both hematopoietic and stromal malignant cells. Targeting MCSCs and their cytokine release has potential as a novel therapeutic approach in AML. |
| first_indexed | 2024-12-22T22:43:37Z |
| format | Article |
| id | doaj.art-0e82795f0dfb412d9904bec2447fef6f |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-22T22:43:37Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-0e82795f0dfb412d9904bec2447fef6f2022-12-21T18:10:08ZengBMCJournal of Hematology & Oncology1756-87222020-06-011311410.1186/s13045-020-00899-xDiscovery of proangiogenic CD44+mesenchymal cancer stem cells in an acute myeloid leukemia patient’s bone marrowHuynh Cao0Jeffrey Xiao1Mark E. Reeves2Kimberly Payne3Chien Shing Chen4David J. Baylink5Guido Marcucci6Yi Xu7Division of Hematology and Oncology, Loma Linda University Medical CenterRegenerative Medicine, Department of Medicine, Loma Linda UniversityDivision of Hematology and Oncology, Loma Linda University Medical CenterDivision of Anatomy, Department of Basic Sciences, Loma Linda UniversityDivision of Hematology and Oncology, Loma Linda University Medical CenterRegenerative Medicine, Department of Medicine, Loma Linda UniversityGehr Family Center for Leukemia Research, Hematology Malignancies and Stem Cell Transplantation Institute, City of Hope Medical CenterDivision of Hematology and Oncology, Loma Linda University Medical CenterAbstract Here, we report a unique acute myeloid leukemia (AML) bone marrow-derived mesenchymal stem cell (MSC) with both mesenchymal and endothelial potential, which we have named Mesenchymal Cancer Stem Cells (MCSCs). These MCSCs are CD90-CD13-CD44+ and differ from MSCs in isolation, expansion, differentiation, immunophenotype, and cytokine release profile. Furthermore, blocking CD44 inhibited the proliferation and cluster formation of early MCSCs with lower ICAM-1 protein levels. Similar CD90-CD44+ cancer stem cells have been reported in both gastric and breast cancers, which grew in floating spheres in vitro and exhibited mesenchymal features and high metastatic/tumorigenic capabilities in vivo. Our novel discovery provides the first evidence that certain AMLs may be comprised of both hematopoietic and stromal malignant cells. Targeting MCSCs and their cytokine release has potential as a novel therapeutic approach in AML.http://link.springer.com/article/10.1186/s13045-020-00899-xAcute myeloid leukemiaMesenchymal stem cellsMesenchymal cancer stem cellsCD44AngiogenesisMicroenvironment |
| spellingShingle | Huynh Cao Jeffrey Xiao Mark E. Reeves Kimberly Payne Chien Shing Chen David J. Baylink Guido Marcucci Yi Xu Discovery of proangiogenic CD44+mesenchymal cancer stem cells in an acute myeloid leukemia patient’s bone marrow Journal of Hematology & Oncology Acute myeloid leukemia Mesenchymal stem cells Mesenchymal cancer stem cells CD44 Angiogenesis Microenvironment |
| title | Discovery of proangiogenic CD44+mesenchymal cancer stem cells in an acute myeloid leukemia patient’s bone marrow |
| title_full | Discovery of proangiogenic CD44+mesenchymal cancer stem cells in an acute myeloid leukemia patient’s bone marrow |
| title_fullStr | Discovery of proangiogenic CD44+mesenchymal cancer stem cells in an acute myeloid leukemia patient’s bone marrow |
| title_full_unstemmed | Discovery of proangiogenic CD44+mesenchymal cancer stem cells in an acute myeloid leukemia patient’s bone marrow |
| title_short | Discovery of proangiogenic CD44+mesenchymal cancer stem cells in an acute myeloid leukemia patient’s bone marrow |
| title_sort | discovery of proangiogenic cd44 mesenchymal cancer stem cells in an acute myeloid leukemia patient s bone marrow |
| topic | Acute myeloid leukemia Mesenchymal stem cells Mesenchymal cancer stem cells CD44 Angiogenesis Microenvironment |
| url | http://link.springer.com/article/10.1186/s13045-020-00899-x |
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