The Changing Face of Atherosclerosis
BACKGROUND: Statins have been used for around three decades as the primary way to lower cholesterol and reduce the risk of atherosclerosis, but in some groups, statin resistance is common, and the danger of atherosclerosis is still high. CONTENT: Atherosclerosis was once believed to be caused by ch...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Secretariat of The Indonesian Biomedical Journal
2023-06-01
|
| Series: | Indonesian Biomedical Journal |
| Online Access: | https://inabj.org/index.php/ibj/article/view/2347 |
| _version_ | 1827916474630537216 |
|---|---|
| author | Anna Meiliana Andi Wijaya |
| author_facet | Anna Meiliana Andi Wijaya |
| author_sort | Anna Meiliana |
| collection | DOAJ |
| description | BACKGROUND: Statins have been used for around three decades as the primary way to lower cholesterol and reduce the risk of atherosclerosis, but in some groups, statin resistance is common, and the danger of atherosclerosis is still high.
CONTENT: Atherosclerosis was once believed to be caused by cholesterol and thrombotic material passively accumulating in the walls of arteries. However, current knowledge shows that the immune cells and inflammatory processes are essential in the formation, progression, and consequences of atherosclerotic lesions, characterized by a persistent inflammatory response, including thrombotic complications. Study of genetic, creating risk score for atherosclerosis, add more information to create more new therapies targeting low density lipoprotein cholesterol (LDL-C) receptor, and shows prospect.
SUMMARY: Over time, atherosclerosis theories and treatment strategies have changed. While statins were widely used, they have now been supplanted by alternative options like the proprotein convertase subtilisin/kexin type 9 (PSCK9) inhibitor that manage atherosclerosis more effectively and comprehensive.
KEYWORDS: atherosclerosis, cholesterol, inflammation, immune system, metabolism |
| first_indexed | 2024-03-13T03:15:40Z |
| format | Article |
| id | doaj.art-0e83ab7c70354cd18c84135f609db460 |
| institution | Directory Open Access Journal |
| issn | 2085-3297 2355-9179 |
| language | English |
| last_indexed | 2024-03-13T03:15:40Z |
| publishDate | 2023-06-01 |
| publisher | Secretariat of The Indonesian Biomedical Journal |
| record_format | Article |
| series | Indonesian Biomedical Journal |
| spelling | doaj.art-0e83ab7c70354cd18c84135f609db4602023-06-26T02:48:39ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792023-06-0115310.18585/inabj.v15i3.2347513The Changing Face of AtherosclerosisAnna Meiliana0Andi Wijaya1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor 45363Prodia Clinical Laboratory, Jl. Supratman No 43, Bandung 40114BACKGROUND: Statins have been used for around three decades as the primary way to lower cholesterol and reduce the risk of atherosclerosis, but in some groups, statin resistance is common, and the danger of atherosclerosis is still high. CONTENT: Atherosclerosis was once believed to be caused by cholesterol and thrombotic material passively accumulating in the walls of arteries. However, current knowledge shows that the immune cells and inflammatory processes are essential in the formation, progression, and consequences of atherosclerotic lesions, characterized by a persistent inflammatory response, including thrombotic complications. Study of genetic, creating risk score for atherosclerosis, add more information to create more new therapies targeting low density lipoprotein cholesterol (LDL-C) receptor, and shows prospect. SUMMARY: Over time, atherosclerosis theories and treatment strategies have changed. While statins were widely used, they have now been supplanted by alternative options like the proprotein convertase subtilisin/kexin type 9 (PSCK9) inhibitor that manage atherosclerosis more effectively and comprehensive. KEYWORDS: atherosclerosis, cholesterol, inflammation, immune system, metabolismhttps://inabj.org/index.php/ibj/article/view/2347 |
| spellingShingle | Anna Meiliana Andi Wijaya The Changing Face of Atherosclerosis Indonesian Biomedical Journal |
| title | The Changing Face of Atherosclerosis |
| title_full | The Changing Face of Atherosclerosis |
| title_fullStr | The Changing Face of Atherosclerosis |
| title_full_unstemmed | The Changing Face of Atherosclerosis |
| title_short | The Changing Face of Atherosclerosis |
| title_sort | changing face of atherosclerosis |
| url | https://inabj.org/index.php/ibj/article/view/2347 |
| work_keys_str_mv | AT annameiliana thechangingfaceofatherosclerosis AT andiwijaya thechangingfaceofatherosclerosis AT annameiliana changingfaceofatherosclerosis AT andiwijaya changingfaceofatherosclerosis |