Changes in ceftriaxone pharmacokinetics/pharmacodynamics during the early phase of sepsis: a prospective, experimental study in the rat

Changes in ceftriaxone pharmacokinetics/pharmacodynamics during the early phase of sepsis: a prospective, experimental study in the rat

Abstract Background Sepsis is characterized by the loss of the perm-selectivity properties of the glomerular filtration barrier (GFB) with consequent albuminuria. We examined whether the pharmacokinetics–pharmacodynamics (PK/PD) of ceftriaxone (CTX), an extensively protein-bound 3rd generation cepha...

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Bibliographic Details
Main Authors: Valentina Selmi, Beatrice Loriga, Luca Vitali, Martina Carlucci, Alessandro Di Filippo, Giulio Carta, Eleonora Sgambati, Lorenzo Tofani, Angelo Raffaele De Gaudio, Andrea Novelli, Chiara Adembri
Format: Article
Language:English
Published: BMC 2016-11-01
Series:Journal of Translational Medicine
Subjects:
Ceftriaxone
Sepsis
Pharmacokinetics/pharmacodynamics
Glomerular filtration barrier
Glycocalyx
Sialic acids
Online Access:http://link.springer.com/article/10.1186/s12967-016-1072-9

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