Effect of EGFR amplification on the prognosis of EGFR-mutated advanced non–small-cell lung cancer patients: a prospective observational study

Effect of EGFR amplification on the prognosis of EGFR-mutated advanced non–small-cell lung cancer patients: a prospective observational study

Abstract Background Epidermal growth factor receptor (EGFR) amplification refers to the copy number increase of EGFR gene, and is often identified as a “bypass” way of Epidermal growth factor receptor Tyrosine kinase inhibitors (EGFR-TKI) resistance. We aimed to explore the effect of EGFR amplificat...

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Bibliographic Details
Main Authors: Duanyang Peng, Pingan Liang, Congying Zhong, Peng Xu, Yanqing He, Yuxi Luo, Xia Wang, Anwen Liu, Zhimin Zeng
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Cancer
Subjects:
Non-small cell lung cancer
EGFR amplification
Tyrosine kinase inhibitors
Progression-free survival
EGFR mutation
Online Access:https://doi.org/10.1186/s12885-022-10390-0

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