Advances in the study of the association between IL-17 and acne
Acne is a chronic inflammatory disease involving the sebaceous unit of hair follicles, with a complex pathogenesis. Currently, it is believed that the pathogenesis of acne is related to androgen levels, excessive sebum secretion, hyperkeratosis of hair follicles, C.acnes and others. In recent years,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2023-12-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.06.009 |
| _version_ | 1797249325572554752 |
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| author | Yixue DUAN Ju WEN Si QIN Wenbin HUANG Mujin LI |
| author_facet | Yixue DUAN Ju WEN Si QIN Wenbin HUANG Mujin LI |
| author_sort | Yixue DUAN |
| collection | DOAJ |
| description | Acne is a chronic inflammatory disease involving the sebaceous unit of hair follicles, with a complex pathogenesis. Currently, it is believed that the pathogenesis of acne is related to androgen levels, excessive sebum secretion, hyperkeratosis of hair follicles, C.acnes and others. In recent years, studies have revealed the pathogenic role of a variety of inflammatory factors in acne, among which IL-17 is highly expressed in the epidermis and serum of acne patients, and its levels are positively correlated with the severity of acne, becoming a biomarker for early diagnosis of acne. A large amount of evidence indicates the involvement of IL-17 in the pathogenesis of acne, possibly playing a dominant role. IL-17 is involved in the inflammatory cascade of various acne, thereby changing severity of inflammation. But the specific mechanisms are not clear. This article reviews the research progress of the correlation between IL-17 and acne, and discusses the anti-inflammatory and therapeutic effects of anti-IL-7 on acne, in order to determine the pathogenic role of IL-17 in acne. |
| first_indexed | 2024-04-24T20:28:41Z |
| format | Article |
| id | doaj.art-0e878f1d37914aee9fba1183e047984c |
| institution | Directory Open Access Journal |
| issn | 1674-8468 |
| language | zho |
| last_indexed | 2024-04-24T20:28:41Z |
| publishDate | 2023-12-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj.art-0e878f1d37914aee9fba1183e047984c2024-03-22T02:46:48Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682023-12-0130653453810.3969/j.issn.1674-8468.2023.06.009Advances in the study of the association between IL-17 and acneYixue DUAN0Ju WEN1Si QIN2Wenbin HUANG3Mujin LI4Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, ChinaAffiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, ChinaAffiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, ChinaAffiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, ChinaAffiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, ChinaAcne is a chronic inflammatory disease involving the sebaceous unit of hair follicles, with a complex pathogenesis. Currently, it is believed that the pathogenesis of acne is related to androgen levels, excessive sebum secretion, hyperkeratosis of hair follicles, C.acnes and others. In recent years, studies have revealed the pathogenic role of a variety of inflammatory factors in acne, among which IL-17 is highly expressed in the epidermis and serum of acne patients, and its levels are positively correlated with the severity of acne, becoming a biomarker for early diagnosis of acne. A large amount of evidence indicates the involvement of IL-17 in the pathogenesis of acne, possibly playing a dominant role. IL-17 is involved in the inflammatory cascade of various acne, thereby changing severity of inflammation. But the specific mechanisms are not clear. This article reviews the research progress of the correlation between IL-17 and acne, and discusses the anti-inflammatory and therapeutic effects of anti-IL-7 on acne, in order to determine the pathogenic role of IL-17 in acne.http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.06.009acneil-17il-17ac.acnes |
| spellingShingle | Yixue DUAN Ju WEN Si QIN Wenbin HUANG Mujin LI Advances in the study of the association between IL-17 and acne Pifu-xingbing zhenliaoxue zazhi acne il-17 il-17a c.acnes |
| title | Advances in the study of the association between IL-17 and acne |
| title_full | Advances in the study of the association between IL-17 and acne |
| title_fullStr | Advances in the study of the association between IL-17 and acne |
| title_full_unstemmed | Advances in the study of the association between IL-17 and acne |
| title_short | Advances in the study of the association between IL-17 and acne |
| title_sort | advances in the study of the association between il 17 and acne |
| topic | acne il-17 il-17a c.acnes |
| url | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.06.009 |
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