Frontotemporal Lobe Degeneration as Origin of Scans Without Evidence of Dopaminergic Deficit
The term scans without evidence of dopaminergic deficit (SWEDD) can be associated with any patient diagnosed at first with Parkinson’s disease but with a negative dopamine transporter-single photon emission computed tomography (DaTSPECT), which does not confirm the presynaptic dopaminergic deficienc...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-05-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00335/full |
| _version_ | 1819051926498574336 |
|---|---|
| author | Manuel Menéndez-González Manuel Menéndez-González Manuel Menéndez-González Tania Álvarez-Avellón José M. Salas-Pacheco Benito de Celis-Alonso Kathryn A. Wyman-Chick Oscar Arias-Carrión |
| author_facet | Manuel Menéndez-González Manuel Menéndez-González Manuel Menéndez-González Tania Álvarez-Avellón José M. Salas-Pacheco Benito de Celis-Alonso Kathryn A. Wyman-Chick Oscar Arias-Carrión |
| author_sort | Manuel Menéndez-González |
| collection | DOAJ |
| description | The term scans without evidence of dopaminergic deficit (SWEDD) can be associated with any patient diagnosed at first with Parkinson’s disease but with a negative dopamine transporter-single photon emission computed tomography (DaTSPECT), which does not confirm the presynaptic dopaminergic deficiency. Therefore, an alternative diagnosis should be sought to support parkinsonism as a clinical diagnosis. Parkinsonism is a well-known manifestation of frontotemporal lobar degeneration (FTLD), particularly frequent in those with positive DaTSPECT. Here, we reinforce previous observations that parkinsonism can be present in FTLD patients with negative DaTSPECT and therefore, FTLD may account for a percentage of patients with SWEDD. We gather the clinical observations supporting this hypothesis and describe a case report illustrating this idea. Studies suggest the result of DaTSPECT in FTLD may depend on the neuropathology and clinical subtype. However, most studies do not provide a clinical description of the clinical subtype or pathological features making the association between subtypes of FTLD and DaTSPECT results impossible at the moment. Further studies correlating clinical, neuropsychological, neuroimaging, genetic, and pathology findings are needed to better understand parkinsonism in FTLD. |
| first_indexed | 2024-12-21T12:11:42Z |
| format | Article |
| id | doaj.art-0e8874788bd44aa287b07389572870a3 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-21T12:11:42Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0e8874788bd44aa287b07389572870a32022-12-21T19:04:33ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-05-01910.3389/fneur.2018.00335350021Frontotemporal Lobe Degeneration as Origin of Scans Without Evidence of Dopaminergic DeficitManuel Menéndez-González0Manuel Menéndez-González1Manuel Menéndez-González2Tania Álvarez-Avellón3José M. Salas-Pacheco4Benito de Celis-Alonso5Kathryn A. Wyman-Chick6Oscar Arias-Carrión7Servicio de Neurología, Hospital Universitario Central de Asturias, Oviedo, SpainInstituto de Investigación Sanitaria del Principado de Asturias, Oviedo, SpainDepartamento de Morfología y Biología Funcional, Universidad de Oviedo, Oviedo, SpainDepartamento de Psicología, Universidad de Oviedo, Oviedo, SpainInstituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango, MéxicoFacultad de Ciencias Físico Matemáticas, Benemérita Universidad Autónoma de Puebla, Puebla, MéxicoRegions Hospital/Health Partners Neuroscience Center, Saint Paul, MN, United StatesUnidad de Trastornos del Movimiento y Sueño/Centro de Innovación Médica Aplicada, Hospital General Dr. Manuel Gea González, Ciudad de México, MéxicoThe term scans without evidence of dopaminergic deficit (SWEDD) can be associated with any patient diagnosed at first with Parkinson’s disease but with a negative dopamine transporter-single photon emission computed tomography (DaTSPECT), which does not confirm the presynaptic dopaminergic deficiency. Therefore, an alternative diagnosis should be sought to support parkinsonism as a clinical diagnosis. Parkinsonism is a well-known manifestation of frontotemporal lobar degeneration (FTLD), particularly frequent in those with positive DaTSPECT. Here, we reinforce previous observations that parkinsonism can be present in FTLD patients with negative DaTSPECT and therefore, FTLD may account for a percentage of patients with SWEDD. We gather the clinical observations supporting this hypothesis and describe a case report illustrating this idea. Studies suggest the result of DaTSPECT in FTLD may depend on the neuropathology and clinical subtype. However, most studies do not provide a clinical description of the clinical subtype or pathological features making the association between subtypes of FTLD and DaTSPECT results impossible at the moment. Further studies correlating clinical, neuropsychological, neuroimaging, genetic, and pathology findings are needed to better understand parkinsonism in FTLD.https://www.frontiersin.org/article/10.3389/fneur.2018.00335/fullscans without evidence of dopaminergic deficitparkinsonismdopamine transporter-singlephoton emission computed tomographypresynaptic dopaminergic deficiencyfrontotemporal lobar degeneration |
| spellingShingle | Manuel Menéndez-González Manuel Menéndez-González Manuel Menéndez-González Tania Álvarez-Avellón José M. Salas-Pacheco Benito de Celis-Alonso Kathryn A. Wyman-Chick Oscar Arias-Carrión Frontotemporal Lobe Degeneration as Origin of Scans Without Evidence of Dopaminergic Deficit Frontiers in Neurology scans without evidence of dopaminergic deficit parkinsonism dopamine transporter-single photon emission computed tomography presynaptic dopaminergic deficiency frontotemporal lobar degeneration |
| title | Frontotemporal Lobe Degeneration as Origin of Scans Without Evidence of Dopaminergic Deficit |
| title_full | Frontotemporal Lobe Degeneration as Origin of Scans Without Evidence of Dopaminergic Deficit |
| title_fullStr | Frontotemporal Lobe Degeneration as Origin of Scans Without Evidence of Dopaminergic Deficit |
| title_full_unstemmed | Frontotemporal Lobe Degeneration as Origin of Scans Without Evidence of Dopaminergic Deficit |
| title_short | Frontotemporal Lobe Degeneration as Origin of Scans Without Evidence of Dopaminergic Deficit |
| title_sort | frontotemporal lobe degeneration as origin of scans without evidence of dopaminergic deficit |
| topic | scans without evidence of dopaminergic deficit parkinsonism dopamine transporter-single photon emission computed tomography presynaptic dopaminergic deficiency frontotemporal lobar degeneration |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00335/full |
| work_keys_str_mv | AT manuelmenendezgonzalez frontotemporallobedegenerationasoriginofscanswithoutevidenceofdopaminergicdeficit AT manuelmenendezgonzalez frontotemporallobedegenerationasoriginofscanswithoutevidenceofdopaminergicdeficit AT manuelmenendezgonzalez frontotemporallobedegenerationasoriginofscanswithoutevidenceofdopaminergicdeficit AT taniaalvarezavellon frontotemporallobedegenerationasoriginofscanswithoutevidenceofdopaminergicdeficit AT josemsalaspacheco frontotemporallobedegenerationasoriginofscanswithoutevidenceofdopaminergicdeficit AT benitodecelisalonso frontotemporallobedegenerationasoriginofscanswithoutevidenceofdopaminergicdeficit AT kathrynawymanchick frontotemporallobedegenerationasoriginofscanswithoutevidenceofdopaminergicdeficit AT oscarariascarrion frontotemporallobedegenerationasoriginofscanswithoutevidenceofdopaminergicdeficit |