Downregulation of Cell Cycle and Checkpoint Genes by Class I HDAC Inhibitors Limits Synergism with G2/M Checkpoint Inhibitor MK-1775 in Bladder Cancer Cells

Downregulation of Cell Cycle and Checkpoint Genes by Class I HDAC Inhibitors Limits Synergism with G2/M Checkpoint Inhibitor MK-1775 in Bladder Cancer Cells

Since genes encoding epigenetic regulators are often mutated or deregulated in urothelial carcinoma (UC), they represent promising therapeutic targets. Specifically, inhibition of Class-I histone deacetylase (HDAC) isoenzymes induces cell death in UC cell lines (UCC) and, in contrast to other cancer...

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Bibliographic Details
Main Authors: Michèle J. Hoffmann, Sarah Meneceur, Katrin Hommel, Wolfgang A. Schulz, Günter Niegisch
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Genes
Subjects:
bladder cancer
cell cycle gene
cell cycle arrest
HDAC
epigenetic inhibitor
Romidepsin
Online Access:https://www.mdpi.com/2073-4425/12/2/260

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