Angiogenic and Microvascular Status Alterations after Endovascular Revascularization of Lower Limb Arteries among Patients with Diabetic Foot Syndrome: A Prospective 12-Month Follow-Up Study
Peripheral arterial disease (PAD)-induced ischemia is an important component of diabetic foot syndrome (DFS). The results of revascularization of the lower extremity arteries (including percutaneous transluminal angioplasty [PTA]) do not always give satisfactory long-term results, which is due to ma...
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MDPI AG
2023-08-01
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| author | Martyna Schönborn Iwona Gregorczyk-Maga Krzysztof Batko Mikołaj Maga Katarzyna Bogucka Katarzyna Gawlik Dorota Pawlica-Gosiewska Paweł Maga |
| author_facet | Martyna Schönborn Iwona Gregorczyk-Maga Krzysztof Batko Mikołaj Maga Katarzyna Bogucka Katarzyna Gawlik Dorota Pawlica-Gosiewska Paweł Maga |
| author_sort | Martyna Schönborn |
| collection | DOAJ |
| description | Peripheral arterial disease (PAD)-induced ischemia is an important component of diabetic foot syndrome (DFS). The results of revascularization of the lower extremity arteries (including percutaneous transluminal angioplasty [PTA]) do not always give satisfactory long-term results, which is due to many factors. The aim of the study was to investigate the alterations in selected circulating angiogenic factors and microcirculation parameters in 41 patients with DFS following PTA and analyze their relationships with clinical outcomes during 1-year follow-up. Our study revealed a general decrease in pro-angiogenic factor levels after PTA and their subsequent stabilization during subsequent observation. The results indicated a significant association between plasma circulating FGF-2 level and poor outcomes (including the incidence of restenosis/reocclusion of treated arteries) during 12 months of observation. The perioperative changes in FGF-2 showed a significant association with LDF alterations after PTA. Follow-up 1–3 months post-intervention showed a tendency towards elevated TcpO2, VEGF-A, and VEGF-R2 levels in patients free from adverse events. These results may provide a basis for further research on the potential use of selected circulating angiogenic factors for monitoring the treatment of patients with DFS following PTA. |
| first_indexed | 2024-03-10T23:19:09Z |
| format | Article |
| id | doaj.art-0e8bdfb317e34bf388dbb3ee8bf61d09 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T23:19:09Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0e8bdfb317e34bf388dbb3ee8bf61d092023-11-19T08:22:36ZengMDPI AGJournal of Clinical Medicine2077-03832023-08-011217558110.3390/jcm12175581Angiogenic and Microvascular Status Alterations after Endovascular Revascularization of Lower Limb Arteries among Patients with Diabetic Foot Syndrome: A Prospective 12-Month Follow-Up StudyMartyna Schönborn0Iwona Gregorczyk-Maga1Krzysztof Batko2Mikołaj Maga3Katarzyna Bogucka4Katarzyna Gawlik5Dorota Pawlica-Gosiewska6Paweł Maga7Department of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krakow, PolandFaculty of Medicine, Institute of Dentistry, Jagiellonian University Medical College, 31-008 Kraków, PolandDepartment of Research and Development, Medicine Economy Law Society (MELS) Foundation, 30-040 Krakow, PolandDepartment of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krakow, PolandClinical Department of Angiology, University Hospital in Krakow, 30-688 Kraków, PolandDepartment of Clinical Biochemistry, Jagiellonian University Medical College, 31-008 Krakow, PolandDepartment of Clinical Biochemistry, Jagiellonian University Medical College, 31-008 Krakow, PolandDepartment of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krakow, PolandPeripheral arterial disease (PAD)-induced ischemia is an important component of diabetic foot syndrome (DFS). The results of revascularization of the lower extremity arteries (including percutaneous transluminal angioplasty [PTA]) do not always give satisfactory long-term results, which is due to many factors. The aim of the study was to investigate the alterations in selected circulating angiogenic factors and microcirculation parameters in 41 patients with DFS following PTA and analyze their relationships with clinical outcomes during 1-year follow-up. Our study revealed a general decrease in pro-angiogenic factor levels after PTA and their subsequent stabilization during subsequent observation. The results indicated a significant association between plasma circulating FGF-2 level and poor outcomes (including the incidence of restenosis/reocclusion of treated arteries) during 12 months of observation. The perioperative changes in FGF-2 showed a significant association with LDF alterations after PTA. Follow-up 1–3 months post-intervention showed a tendency towards elevated TcpO2, VEGF-A, and VEGF-R2 levels in patients free from adverse events. These results may provide a basis for further research on the potential use of selected circulating angiogenic factors for monitoring the treatment of patients with DFS following PTA.https://www.mdpi.com/2077-0383/12/17/5581angiogenesismicrocirculationangioplastyrevascularizationdiabetic foot syndrome |
| spellingShingle | Martyna Schönborn Iwona Gregorczyk-Maga Krzysztof Batko Mikołaj Maga Katarzyna Bogucka Katarzyna Gawlik Dorota Pawlica-Gosiewska Paweł Maga Angiogenic and Microvascular Status Alterations after Endovascular Revascularization of Lower Limb Arteries among Patients with Diabetic Foot Syndrome: A Prospective 12-Month Follow-Up Study Journal of Clinical Medicine angiogenesis microcirculation angioplasty revascularization diabetic foot syndrome |
| title | Angiogenic and Microvascular Status Alterations after Endovascular Revascularization of Lower Limb Arteries among Patients with Diabetic Foot Syndrome: A Prospective 12-Month Follow-Up Study |
| title_full | Angiogenic and Microvascular Status Alterations after Endovascular Revascularization of Lower Limb Arteries among Patients with Diabetic Foot Syndrome: A Prospective 12-Month Follow-Up Study |
| title_fullStr | Angiogenic and Microvascular Status Alterations after Endovascular Revascularization of Lower Limb Arteries among Patients with Diabetic Foot Syndrome: A Prospective 12-Month Follow-Up Study |
| title_full_unstemmed | Angiogenic and Microvascular Status Alterations after Endovascular Revascularization of Lower Limb Arteries among Patients with Diabetic Foot Syndrome: A Prospective 12-Month Follow-Up Study |
| title_short | Angiogenic and Microvascular Status Alterations after Endovascular Revascularization of Lower Limb Arteries among Patients with Diabetic Foot Syndrome: A Prospective 12-Month Follow-Up Study |
| title_sort | angiogenic and microvascular status alterations after endovascular revascularization of lower limb arteries among patients with diabetic foot syndrome a prospective 12 month follow up study |
| topic | angiogenesis microcirculation angioplasty revascularization diabetic foot syndrome |
| url | https://www.mdpi.com/2077-0383/12/17/5581 |
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