Defective mitochondria‐lysosomal axis enhances the release of extracellular vesicles containing mitochondrial DNA and proteins in Huntington's disease

Defective mitochondria‐lysosomal axis enhances the release of extracellular vesicles containing mitochondrial DNA and proteins in Huntington's disease

Abstract Mitochondrial and autophagy dysfunction are mechanisms proposed to be involved in the pathogenesis of several neurodegenerative diseases. Huntington's disease (HD) is a progressive neurodegenerative disorder associated with mutant Huntingtin‐induced abnormalities in neuronal mitochondr...

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Bibliographic Details
Main Authors: Margarida Beatriz, Rita Vilaça, Sandra I. Anjo, Bruno Manadas, Cristina Januário, A. Cristina Rego, Carla Lopes
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Journal of Extracellular Biology
Subjects:
autophagy
extracellular vesicles
Huntington's disease
mitochondrial DNA
mitochondrial dysfunction
neuronal‐derived extracellular vesicles
Online Access:https://doi.org/10.1002/jex2.65

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