Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine
The p53 tumor suppressor plays a major role in controlling the initiation and development of cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 oncogene is a major negative regulator of p53 that inhibits the activity of p53 and reduces its protein stability. MDM2...
Main Authors: | Jiang-Jiang Qin, Xin Li, Courtney Hunt, Wei Wang, Hui Wang, Ruiwen Zhang |
---|---|
Format: | Article |
Language: | English |
Published: |
KeAi Communications Co., Ltd.
2018-09-01
|
Series: | Genes and Diseases |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304218300758 |
Similar Items
-
Targeting the MDM2-p53 pathway in dedifferentiated liposarcoma
by: Raymond S. Traweek, et al.
Published: (2022-11-01) -
Detection of P53 and Mdm2 in vitiligo
by: Viroj Wiwanitkit
Published: (2013-01-01) -
Small Molecule Inhibitors of MDM2-p53 and MDMX-p53 Interactions as New Cancer Therapeutics
by: Yujun Zhao, et al.
Published: (2013-07-01) -
Controlling the Mdm2-Mdmx-p53 Circuit
by: David L. Waning, et al.
Published: (2010-05-01) -
Correction: Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2
Published: (2013-01-01)