A Case of Tuberculous Meningitis with Paradoxical Response in a 14-Year-Old Boy

A clinical or radiological worsening of already existing lesions or an emergence of new lesions after beginning treatment in patients with tuberculosis (TB) is referred to as the paradoxical response. This has aroused suspicion regarding the accuracy of diagnosis, the possibilities of treatment fail...

Full description

Bibliographic Details
Main Authors: Murat Özer, Yasemin Özsürekci, Ali Bülent Cengiz, Nagehan Emiralioğlu, Deniz Doğru, Kader Karlı Oğuz, Onur Akça, Özgür Özkayar
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Case Reports in Infectious Diseases
Online Access:http://dx.doi.org/10.1155/2016/5875628
_version_ 1827009474261417984
author Murat Özer
Yasemin Özsürekci
Ali Bülent Cengiz
Nagehan Emiralioğlu
Deniz Doğru
Kader Karlı Oğuz
Onur Akça
Özgür Özkayar
author_facet Murat Özer
Yasemin Özsürekci
Ali Bülent Cengiz
Nagehan Emiralioğlu
Deniz Doğru
Kader Karlı Oğuz
Onur Akça
Özgür Özkayar
author_sort Murat Özer
collection DOAJ
description A clinical or radiological worsening of already existing lesions or an emergence of new lesions after beginning treatment in patients with tuberculosis (TB) is referred to as the paradoxical response. This has aroused suspicion regarding the accuracy of diagnosis, the possibilities of treatment failure, or the presence of another underlying disease, and thus it is an important topic for clinicians to understand. In this article, the development of a paradox reaction in a 14-year-old male patient diagnosed with and treated for tuberculosis meningitis is reported. This pediatric patient with a healthy immune system is treated with steroids successfully and reported to elucidate the importance of managing the paradox of TB progression in spite of the appropriate anti-TB medications.
first_indexed 2024-04-14T01:41:01Z
format Article
id doaj.art-0e8f0803cea44b32897bb5ceae503d75
institution Directory Open Access Journal
issn 2090-6625
2090-6633
language English
last_indexed 2025-02-18T12:50:13Z
publishDate 2016-01-01
publisher Hindawi Limited
record_format Article
series Case Reports in Infectious Diseases
spelling doaj.art-0e8f0803cea44b32897bb5ceae503d752024-11-02T03:58:31ZengHindawi LimitedCase Reports in Infectious Diseases2090-66252090-66332016-01-01201610.1155/2016/58756285875628A Case of Tuberculous Meningitis with Paradoxical Response in a 14-Year-Old BoyMurat Özer0Yasemin Özsürekci1Ali Bülent Cengiz2Nagehan Emiralioğlu3Deniz Doğru4Kader Karlı Oğuz5Onur Akça6Özgür Özkayar7Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, TurkeyPediatric Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, TurkeyPediatric Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, TurkeyPediatric Chest Diseases, Hacettepe University Faculty of Medicine, Ankara, TurkeyPediatric Chest Diseases, Hacettepe University Faculty of Medicine, Ankara, TurkeyDepartment of Radiology, Hacettepe University Faculty of Medicine, Ankara, TurkeyDepartment of Radiology, Hacettepe University Faculty of Medicine, Ankara, TurkeyDepartment of Pathology, Hacettepe University Faculty of Medicine, Ankara, TurkeyA clinical or radiological worsening of already existing lesions or an emergence of new lesions after beginning treatment in patients with tuberculosis (TB) is referred to as the paradoxical response. This has aroused suspicion regarding the accuracy of diagnosis, the possibilities of treatment failure, or the presence of another underlying disease, and thus it is an important topic for clinicians to understand. In this article, the development of a paradox reaction in a 14-year-old male patient diagnosed with and treated for tuberculosis meningitis is reported. This pediatric patient with a healthy immune system is treated with steroids successfully and reported to elucidate the importance of managing the paradox of TB progression in spite of the appropriate anti-TB medications.http://dx.doi.org/10.1155/2016/5875628
spellingShingle Murat Özer
Yasemin Özsürekci
Ali Bülent Cengiz
Nagehan Emiralioğlu
Deniz Doğru
Kader Karlı Oğuz
Onur Akça
Özgür Özkayar
A Case of Tuberculous Meningitis with Paradoxical Response in a 14-Year-Old Boy
Case Reports in Infectious Diseases
title A Case of Tuberculous Meningitis with Paradoxical Response in a 14-Year-Old Boy
title_full A Case of Tuberculous Meningitis with Paradoxical Response in a 14-Year-Old Boy
title_fullStr A Case of Tuberculous Meningitis with Paradoxical Response in a 14-Year-Old Boy
title_full_unstemmed A Case of Tuberculous Meningitis with Paradoxical Response in a 14-Year-Old Boy
title_short A Case of Tuberculous Meningitis with Paradoxical Response in a 14-Year-Old Boy
title_sort case of tuberculous meningitis with paradoxical response in a 14 year old boy
url http://dx.doi.org/10.1155/2016/5875628
work_keys_str_mv AT muratozer acaseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT yaseminozsurekci acaseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT alibulentcengiz acaseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT nagehanemiralioglu acaseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT denizdogru acaseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT kaderkarlıoguz acaseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT onurakca acaseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT ozgurozkayar acaseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT muratozer caseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT yaseminozsurekci caseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT alibulentcengiz caseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT nagehanemiralioglu caseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT denizdogru caseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT kaderkarlıoguz caseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT onurakca caseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy
AT ozgurozkayar caseoftuberculousmeningitiswithparadoxicalresponseina14yearoldboy