Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia

Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia

Apolipoprotein C-II (APOC2) is an obligatory activator of lipoprotein lipase. Human patients with APOC2 deficiency display severe hypertriglyceridemia while consuming a normal diet, often manifesting xanthomas, lipemia retinalis and pancreatitis. Hypertriglyceridemia is also an important risk factor...

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Bibliographic Details
Main Authors: Chao Liu, Keith P. Gates, Longhou Fang, Marcelo J. Amar, Dina A. Schneider, Honglian Geng, Wei Huang, Jungsu Kim, Jennifer Pattison, Jian Zhang, Joseph L. Witztum, Alan T. Remaley, P. Duc Dong, Yury I. Miller
Format: Article
Language:English
Published: The Company of Biologists 2015-08-01
Series:Disease Models & Mechanisms
Subjects:
Zebrafish
Apolipoprotein C-II
APOC2
Lipoprotein lipase
Hyperlipidemia
Online Access:http://dmm.biologists.org/content/8/8/989

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