Au nanozyme-based multifunctional hydrogel for inflammation visible monitoring and treatment
Chronic inflammation can delay wound healing, eventually leading to tissue necrosis and even cancer. Developing real-time intelligent inflammation monitoring and treatment to achieve effective wound management is important to promote wound healing. In this study, a smart multifunctional hydrogel (Hy...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259000642400019X |
| _version_ | 1797258635086135296 |
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| author | Yunjing Jiang Yuyu Cao Jie Wu Rongxian Bai Shufan Wan Lei Dai Jiangtao Su Hongmei Sun |
| author_facet | Yunjing Jiang Yuyu Cao Jie Wu Rongxian Bai Shufan Wan Lei Dai Jiangtao Su Hongmei Sun |
| author_sort | Yunjing Jiang |
| collection | DOAJ |
| description | Chronic inflammation can delay wound healing, eventually leading to tissue necrosis and even cancer. Developing real-time intelligent inflammation monitoring and treatment to achieve effective wound management is important to promote wound healing. In this study, a smart multifunctional hydrogel (Hydrogel@Au NCs&DG) was proposed to monitor and treat the wound inflammation. It was prepared by mixing 3-carboxy-phenylboronic acid modified chitosan (CS-cPBA), β-glycerophosphate (β-GP), albumin-protected gold nanoclusters (BSA-Au NCs), and dipotassium glycyrrhizinate (DG) about 10 s. In this hydrogel, CS-cPBA and β-GP are crosslinked together by boric acid ester bond and hydrogen bond to form the main hydrogel network, endowing the hydrogel with self-healing and injectable properties to adapt irregular wounds. Importantly, the as-prepared hydrogel with good biocompatibility and excellent adhesion property could directly determine the H2O2 to monitor the wound microenvironment by visible fluorescence change of BSA-Au NCs and then guide the frequency of dressing change to eliminate inflammation. The results demonstrated that the as-prepared smart hydrogel could be expected to serve as an intelligent wound dressing to promote inflammation-infected wound healing. |
| first_indexed | 2024-03-08T09:27:32Z |
| format | Article |
| id | doaj.art-0e902f7ab8e842d7ac0de13d8def1dc3 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-24T22:56:40Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-0e902f7ab8e842d7ac0de13d8def1dc32024-03-18T04:34:17ZengElsevierMaterials Today Bio2590-00642024-04-0125100960Au nanozyme-based multifunctional hydrogel for inflammation visible monitoring and treatmentYunjing Jiang0Yuyu Cao1Jie Wu2Rongxian Bai3Shufan Wan4Lei Dai5Jiangtao Su6Hongmei Sun7Collaborative Grant-in-Aid of the HBUT National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Key Laboratory of Industrial Microbiology in Hubei, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), School of Bioengineering and Food, Hubei University of Technology, Wuhan, 430068, ChinaCollaborative Grant-in-Aid of the HBUT National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Key Laboratory of Industrial Microbiology in Hubei, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), School of Bioengineering and Food, Hubei University of Technology, Wuhan, 430068, ChinaCollaborative Grant-in-Aid of the HBUT National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Key Laboratory of Industrial Microbiology in Hubei, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), School of Bioengineering and Food, Hubei University of Technology, Wuhan, 430068, ChinaCollaborative Grant-in-Aid of the HBUT National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Key Laboratory of Industrial Microbiology in Hubei, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), School of Bioengineering and Food, Hubei University of Technology, Wuhan, 430068, ChinaCollaborative Grant-in-Aid of the HBUT National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Key Laboratory of Industrial Microbiology in Hubei, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), School of Bioengineering and Food, Hubei University of Technology, Wuhan, 430068, ChinaCollaborative Grant-in-Aid of the HBUT National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Key Laboratory of Industrial Microbiology in Hubei, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), School of Bioengineering and Food, Hubei University of Technology, Wuhan, 430068, ChinaCollaborative Grant-in-Aid of the HBUT National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Key Laboratory of Industrial Microbiology in Hubei, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), School of Bioengineering and Food, Hubei University of Technology, Wuhan, 430068, ChinaCorresponding author.; Collaborative Grant-in-Aid of the HBUT National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Key Laboratory of Industrial Microbiology in Hubei, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), School of Bioengineering and Food, Hubei University of Technology, Wuhan, 430068, ChinaChronic inflammation can delay wound healing, eventually leading to tissue necrosis and even cancer. Developing real-time intelligent inflammation monitoring and treatment to achieve effective wound management is important to promote wound healing. In this study, a smart multifunctional hydrogel (Hydrogel@Au NCs&DG) was proposed to monitor and treat the wound inflammation. It was prepared by mixing 3-carboxy-phenylboronic acid modified chitosan (CS-cPBA), β-glycerophosphate (β-GP), albumin-protected gold nanoclusters (BSA-Au NCs), and dipotassium glycyrrhizinate (DG) about 10 s. In this hydrogel, CS-cPBA and β-GP are crosslinked together by boric acid ester bond and hydrogen bond to form the main hydrogel network, endowing the hydrogel with self-healing and injectable properties to adapt irregular wounds. Importantly, the as-prepared hydrogel with good biocompatibility and excellent adhesion property could directly determine the H2O2 to monitor the wound microenvironment by visible fluorescence change of BSA-Au NCs and then guide the frequency of dressing change to eliminate inflammation. The results demonstrated that the as-prepared smart hydrogel could be expected to serve as an intelligent wound dressing to promote inflammation-infected wound healing.http://www.sciencedirect.com/science/article/pii/S259000642400019XGold nanoclustersMultifunctional hydrogelInflammationVisible monitoringWound healing |
| spellingShingle | Yunjing Jiang Yuyu Cao Jie Wu Rongxian Bai Shufan Wan Lei Dai Jiangtao Su Hongmei Sun Au nanozyme-based multifunctional hydrogel for inflammation visible monitoring and treatment Materials Today Bio Gold nanoclusters Multifunctional hydrogel Inflammation Visible monitoring Wound healing |
| title | Au nanozyme-based multifunctional hydrogel for inflammation visible monitoring and treatment |
| title_full | Au nanozyme-based multifunctional hydrogel for inflammation visible monitoring and treatment |
| title_fullStr | Au nanozyme-based multifunctional hydrogel for inflammation visible monitoring and treatment |
| title_full_unstemmed | Au nanozyme-based multifunctional hydrogel for inflammation visible monitoring and treatment |
| title_short | Au nanozyme-based multifunctional hydrogel for inflammation visible monitoring and treatment |
| title_sort | au nanozyme based multifunctional hydrogel for inflammation visible monitoring and treatment |
| topic | Gold nanoclusters Multifunctional hydrogel Inflammation Visible monitoring Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S259000642400019X |
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