RHO GTPase-Related Long Noncoding RNAs in Human Cancers
RHO GTPases are critical signal transducers that regulate cell adhesion, polarity, and migration through multiple signaling pathways. While all these cellular processes are crucial for the maintenance of normal cell homeostasis, disturbances in RHO GTPase-associated signaling pathways contribute to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/21/5386 |
| _version_ | 1797512690040569856 |
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| author | Mahsa Saliani Amin Mirzaiebadizi Niloufar Mosaddeghzadeh Mohammad Reza Ahmadian |
| author_facet | Mahsa Saliani Amin Mirzaiebadizi Niloufar Mosaddeghzadeh Mohammad Reza Ahmadian |
| author_sort | Mahsa Saliani |
| collection | DOAJ |
| description | RHO GTPases are critical signal transducers that regulate cell adhesion, polarity, and migration through multiple signaling pathways. While all these cellular processes are crucial for the maintenance of normal cell homeostasis, disturbances in RHO GTPase-associated signaling pathways contribute to different human diseases, including many malignancies. Several members of the RHO GTPase family are frequently upregulated in human tumors. Abnormal gene regulation confirms the pivotal role of lncRNAs as critical gene regulators, and thus, they could potentially act as oncogenes or tumor suppressors. lncRNAs most likely act as sponges for miRNAs, which are known to be dysregulated in various cancers. In this regard, the significant role of miRNAs targeting RHO GTPases supports the view that the aberrant expression of lncRNAs may reciprocally change the intensity of RHO GTPase-associated signaling pathways. In this review article, we summarize recent advances in lncRNA research, with a specific focus on their sponge effects on RHO GTPase-targeting miRNAs to crucially mediate gene expression in different cancer cell types and tissues. We will focus in particular on five members of the RHO GTPase family, including RHOA, RHOB, RHOC, RAC1, and CDC42, to illustrate the role of lncRNAs in cancer progression. A deeper understanding of the widespread dysregulation of lncRNAs is of fundamental importance for confirmation of their contribution to RHO GTPase-dependent carcinogenesis. |
| first_indexed | 2024-03-10T06:05:15Z |
| format | Article |
| id | doaj.art-0e9046a061174c0aa96307e152689a2a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T06:05:15Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0e9046a061174c0aa96307e152689a2a2023-11-22T20:34:29ZengMDPI AGCancers2072-66942021-10-011321538610.3390/cancers13215386RHO GTPase-Related Long Noncoding RNAs in Human CancersMahsa Saliani0Amin Mirzaiebadizi1Niloufar Mosaddeghzadeh2Mohammad Reza Ahmadian3Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University, 40225 Düsseldorf, GermanyInstitute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University, 40225 Düsseldorf, GermanyInstitute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University, 40225 Düsseldorf, GermanyInstitute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University, 40225 Düsseldorf, GermanyRHO GTPases are critical signal transducers that regulate cell adhesion, polarity, and migration through multiple signaling pathways. While all these cellular processes are crucial for the maintenance of normal cell homeostasis, disturbances in RHO GTPase-associated signaling pathways contribute to different human diseases, including many malignancies. Several members of the RHO GTPase family are frequently upregulated in human tumors. Abnormal gene regulation confirms the pivotal role of lncRNAs as critical gene regulators, and thus, they could potentially act as oncogenes or tumor suppressors. lncRNAs most likely act as sponges for miRNAs, which are known to be dysregulated in various cancers. In this regard, the significant role of miRNAs targeting RHO GTPases supports the view that the aberrant expression of lncRNAs may reciprocally change the intensity of RHO GTPase-associated signaling pathways. In this review article, we summarize recent advances in lncRNA research, with a specific focus on their sponge effects on RHO GTPase-targeting miRNAs to crucially mediate gene expression in different cancer cell types and tissues. We will focus in particular on five members of the RHO GTPase family, including RHOA, RHOB, RHOC, RAC1, and CDC42, to illustrate the role of lncRNAs in cancer progression. A deeper understanding of the widespread dysregulation of lncRNAs is of fundamental importance for confirmation of their contribution to RHO GTPase-dependent carcinogenesis.https://www.mdpi.com/2072-6694/13/21/5386carcinogenesislncRNAsmiRNAsRHO GTPasessignal transductionsponge effect |
| spellingShingle | Mahsa Saliani Amin Mirzaiebadizi Niloufar Mosaddeghzadeh Mohammad Reza Ahmadian RHO GTPase-Related Long Noncoding RNAs in Human Cancers Cancers carcinogenesis lncRNAs miRNAs RHO GTPases signal transduction sponge effect |
| title | RHO GTPase-Related Long Noncoding RNAs in Human Cancers |
| title_full | RHO GTPase-Related Long Noncoding RNAs in Human Cancers |
| title_fullStr | RHO GTPase-Related Long Noncoding RNAs in Human Cancers |
| title_full_unstemmed | RHO GTPase-Related Long Noncoding RNAs in Human Cancers |
| title_short | RHO GTPase-Related Long Noncoding RNAs in Human Cancers |
| title_sort | rho gtpase related long noncoding rnas in human cancers |
| topic | carcinogenesis lncRNAs miRNAs RHO GTPases signal transduction sponge effect |
| url | https://www.mdpi.com/2072-6694/13/21/5386 |
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