Applying Supercritical Fluid Technology to Prepare Ibuprofen Solid Dispersions with Improved Oral Bioavailability

Applying Supercritical Fluid Technology to Prepare Ibuprofen Solid Dispersions with Improved Oral Bioavailability

In this study, supercritical fluid (SCF) technology was applied to prepare reliable solid dispersions of pharmaceutical compounds with limited bioavailability using ibuprofen (IBU) as a model compound. Solid-state characterization of the dispersions was conducted by differential scanning calorimetry...

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Bibliographic Details
Main Authors: Fei Han, Wei Zhang, Ying Wang, Ziyue Xi, Lu Chen, Sanming Li, Lu Xu
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Pharmaceutics
Subjects:
ibuprofen
supercritical fluid
solid dispersion
bioavailability
Online Access:https://www.mdpi.com/1999-4923/11/2/67

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