Clinical Usefulness of Serum Cystatin C as a Marker of Renal Function
BackgroundAccurate renal function measurements are important in the diagnosis and treatment of kidney diseases. In contrast to creatinine, the production of serum cystatin C has been extensively reported to be unaffected by body muscle mass, age, gender, and nutritional status.MethodsOur study inclu...
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2014-08-01
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| Series: | Diabetes & Metabolism Journal |
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| Online Access: | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-278.pdf |
| _version_ | 1811254098138234880 |
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| author | Kwang-Sook Woo Jae-Lim Choi Bo-Ram Kim Ji-Eun Kim Jin-Yeong Han |
| author_facet | Kwang-Sook Woo Jae-Lim Choi Bo-Ram Kim Ji-Eun Kim Jin-Yeong Han |
| author_sort | Kwang-Sook Woo |
| collection | DOAJ |
| description | BackgroundAccurate renal function measurements are important in the diagnosis and treatment of kidney diseases. In contrast to creatinine, the production of serum cystatin C has been extensively reported to be unaffected by body muscle mass, age, gender, and nutritional status.MethodsOur study included 37 samples from diabetic chronic kidney disease (CKD) patients for whom serum creatinine tests had been requested and 40 samples from a healthy populations in Dong-A University Hospital between May 2010 and June 2010. The assay precision (i.e., the coefficient of variation) and the reference range of the serum cystatin C test were evaluated. We compared the estimated glomerular filtration rates (GFRs) based on cystatin C with those based on creatinine. Moreover, we investigated the influences of age, gender, weight, and muscle mass on serum creatinine and serum cystatin C.ResultsThere was a positive correlation between GFR based on creatinine and that based on cystatin C (r=0.79, P<0.0001) among the diabetic CKD patients. Serum creatinine and cystatin C were significantly correlated with body weight and muscle mass, but the strengths of these correlations were greater for serum creatinine. The precision study revealed excellent results for both the high and low controls. The 95% reference interval of cystatin C in the healthy population was 0.371 to 1.236 mg/L.ConclusionBased on these results, we conclude that, despite the strong correlation between serum creatinine and cystatin C, cystatin C is less affected by weight and muscle mass and might represent a better alternative for the assessment of renal function. |
| first_indexed | 2024-04-12T17:02:04Z |
| format | Article |
| id | doaj.art-0e917bf5d55e4400ab20d4b7f0f03556 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-04-12T17:02:04Z |
| publishDate | 2014-08-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-0e917bf5d55e4400ab20d4b7f0f035562022-12-22T03:24:03ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872014-08-0138427828410.4093/dmj.2014.38.4.27814630Clinical Usefulness of Serum Cystatin C as a Marker of Renal FunctionKwang-Sook WooJae-Lim ChoiBo-Ram KimJi-Eun KimJin-Yeong HanBackgroundAccurate renal function measurements are important in the diagnosis and treatment of kidney diseases. In contrast to creatinine, the production of serum cystatin C has been extensively reported to be unaffected by body muscle mass, age, gender, and nutritional status.MethodsOur study included 37 samples from diabetic chronic kidney disease (CKD) patients for whom serum creatinine tests had been requested and 40 samples from a healthy populations in Dong-A University Hospital between May 2010 and June 2010. The assay precision (i.e., the coefficient of variation) and the reference range of the serum cystatin C test were evaluated. We compared the estimated glomerular filtration rates (GFRs) based on cystatin C with those based on creatinine. Moreover, we investigated the influences of age, gender, weight, and muscle mass on serum creatinine and serum cystatin C.ResultsThere was a positive correlation between GFR based on creatinine and that based on cystatin C (r=0.79, P<0.0001) among the diabetic CKD patients. Serum creatinine and cystatin C were significantly correlated with body weight and muscle mass, but the strengths of these correlations were greater for serum creatinine. The precision study revealed excellent results for both the high and low controls. The 95% reference interval of cystatin C in the healthy population was 0.371 to 1.236 mg/L.ConclusionBased on these results, we conclude that, despite the strong correlation between serum creatinine and cystatin C, cystatin C is less affected by weight and muscle mass and might represent a better alternative for the assessment of renal function.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-278.pdfRenal functionSerum creatinineSerum cystatin C |
| spellingShingle | Kwang-Sook Woo Jae-Lim Choi Bo-Ram Kim Ji-Eun Kim Jin-Yeong Han Clinical Usefulness of Serum Cystatin C as a Marker of Renal Function Diabetes & Metabolism Journal Renal function Serum creatinine Serum cystatin C |
| title | Clinical Usefulness of Serum Cystatin C as a Marker of Renal Function |
| title_full | Clinical Usefulness of Serum Cystatin C as a Marker of Renal Function |
| title_fullStr | Clinical Usefulness of Serum Cystatin C as a Marker of Renal Function |
| title_full_unstemmed | Clinical Usefulness of Serum Cystatin C as a Marker of Renal Function |
| title_short | Clinical Usefulness of Serum Cystatin C as a Marker of Renal Function |
| title_sort | clinical usefulness of serum cystatin c as a marker of renal function |
| topic | Renal function Serum creatinine Serum cystatin C |
| url | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-278.pdf |
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