Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks
Mitochondria are dynamic organelles that can undergo fission and fusion. Here the authors identify a novel pathway in which actin dynamically assembles in an Arp2/3- and formin-dependent manner around a subset of cellular mitochondria, promoting localized Drp1-dependent fission and impeding fusion.
Main Authors: | Andrew S. Moore, Yvette C. Wong, Cory L. Simpson, Erika L. F. Holzbaur |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2016-09-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms12886 |
Similar Items
-
Live-cell imaging and analysis of actin-mediated mitochondrial fission
by: Daisuke Shimura, et al.
Published: (2023-03-01) -
Deceleration of fusion-fission cycles improves mitochondrial quality control during aging.
by: Marc Thilo Figge, et al.
Published: (2012-01-01) -
Mathematical modeling of the role of mitochondrial fusion and fission in mitochondrial DNA maintenance.
by: Zhi Yang Tam, et al.
Published: (2013-01-01) -
Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity
by: A.M. Bertholet, et al.
Published: (2016-06-01) -
Control of mitochondrial morphology through differential interactions of mitochondrial fusion and fission proteins.
by: Pinwei Huang, et al.
Published: (2011-01-01)