Attention in spina bifida myelomeningocele: Relations with brain volume and integrity
This study investigated the relations of tectal volume and superior parietal cortex, as well as alterations in tectocortical white matter connectivity, with the orienting and executive control attention networks in individuals with spina bifida myelomeningocele (SBM). Probabilistic diffusion tractog...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158215000650 |
| _version_ | 1828187531618811904 |
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| author | Paulina A. Kulesz Amery Treble-Barna Victoria J. Williams Jenifer Juranek Paul T. Cirino Maureen Dennis Jack M. Fletcher |
| author_facet | Paulina A. Kulesz Amery Treble-Barna Victoria J. Williams Jenifer Juranek Paul T. Cirino Maureen Dennis Jack M. Fletcher |
| author_sort | Paulina A. Kulesz |
| collection | DOAJ |
| description | This study investigated the relations of tectal volume and superior parietal cortex, as well as alterations in tectocortical white matter connectivity, with the orienting and executive control attention networks in individuals with spina bifida myelomeningocele (SBM). Probabilistic diffusion tractography and quantification of tectal and superior parietal cortical volume were performed on 74 individuals aged 8–29 with SBM and a history of hydrocephalus. Behavioral assessments measured posterior (covert orienting) and anterior (conflict resolution, attentional control) attention network functions. Reduced tectal volume was associated with slower covert orienting; reduced superior parietal cortical volume was associated with slower conflict resolution; and increased axial diffusivity and radial diffusivity along both frontal and parietal tectocortical pathways were associated with reduced attentional control. Results suggest that components of both the orienting and executive control attention networks are impaired in SBM. Neuroanatomical disruption to the orienting network appears more robust and a direct consequence of characteristic midbrain dysmorphology; whereas, executive control difficulties may emerge from parietal cortical anomalies and reduced frontal and parietal cortical–subcortical white matter pathways susceptible to the pathophysiological effects of congenital hydrocephalus. |
| first_indexed | 2024-04-12T07:36:27Z |
| format | Article |
| id | doaj.art-0e9400e3e02c4b66a51de73a01b6a6af |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-12T07:36:27Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-0e9400e3e02c4b66a51de73a01b6a6af2022-12-22T03:41:55ZengElsevierNeuroImage: Clinical2213-15822015-01-018C727810.1016/j.nicl.2015.03.022Attention in spina bifida myelomeningocele: Relations with brain volume and integrityPaulina A. Kulesz0Amery Treble-Barna1Victoria J. Williams2Jenifer Juranek3Paul T. Cirino4Maureen Dennis5Jack M. Fletcher6Department of Psychology, University of Houston, USADepartment of Physical Medicine and Rehabilitation, Cincinnati Children's Hospital Medical Center, USADepartment of Psychology, University of Houston, USADepartment of Pediatrics, University of Texas Health Science Center, USADepartment of Psychology, University of Houston, USADepartment Of Surgery And Psychology, University Of Toronto, CanadaDepartment of Psychology, University of Houston, USAThis study investigated the relations of tectal volume and superior parietal cortex, as well as alterations in tectocortical white matter connectivity, with the orienting and executive control attention networks in individuals with spina bifida myelomeningocele (SBM). Probabilistic diffusion tractography and quantification of tectal and superior parietal cortical volume were performed on 74 individuals aged 8–29 with SBM and a history of hydrocephalus. Behavioral assessments measured posterior (covert orienting) and anterior (conflict resolution, attentional control) attention network functions. Reduced tectal volume was associated with slower covert orienting; reduced superior parietal cortical volume was associated with slower conflict resolution; and increased axial diffusivity and radial diffusivity along both frontal and parietal tectocortical pathways were associated with reduced attentional control. Results suggest that components of both the orienting and executive control attention networks are impaired in SBM. Neuroanatomical disruption to the orienting network appears more robust and a direct consequence of characteristic midbrain dysmorphology; whereas, executive control difficulties may emerge from parietal cortical anomalies and reduced frontal and parietal cortical–subcortical white matter pathways susceptible to the pathophysiological effects of congenital hydrocephalus.http://www.sciencedirect.com/science/article/pii/S2213158215000650Attention networkNeuroimagingTectumSuperior parietal cortexTectocortical pathwaysRobust correlations |
| spellingShingle | Paulina A. Kulesz Amery Treble-Barna Victoria J. Williams Jenifer Juranek Paul T. Cirino Maureen Dennis Jack M. Fletcher Attention in spina bifida myelomeningocele: Relations with brain volume and integrity NeuroImage: Clinical Attention network Neuroimaging Tectum Superior parietal cortex Tectocortical pathways Robust correlations |
| title | Attention in spina bifida myelomeningocele: Relations with brain volume and integrity |
| title_full | Attention in spina bifida myelomeningocele: Relations with brain volume and integrity |
| title_fullStr | Attention in spina bifida myelomeningocele: Relations with brain volume and integrity |
| title_full_unstemmed | Attention in spina bifida myelomeningocele: Relations with brain volume and integrity |
| title_short | Attention in spina bifida myelomeningocele: Relations with brain volume and integrity |
| title_sort | attention in spina bifida myelomeningocele relations with brain volume and integrity |
| topic | Attention network Neuroimaging Tectum Superior parietal cortex Tectocortical pathways Robust correlations |
| url | http://www.sciencedirect.com/science/article/pii/S2213158215000650 |
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