Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome
Abstract Guillain-Barre Syndrome (GBS) is an inflammatory disease of the peripheral nervous system. Given that plasma metabolic profiles in GBS patients have never been explored, plasma samples of 38 GBS patients, 22 multiple sclerosis (MS) patients, and 40 healthy controls were analyzed by using un...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-08-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-08338-7 |
| _version_ | 1818835166253023232 |
|---|---|
| author | Hsiang-Yu Tang Daniel Tsun-yee Chiu Jui-Fen Lin Cheng-Yu Huang Kuo-Hsuan Chang Rong-Kuo Lyu Long-Sun Ro Hung-Chou Kuo Mei-Ling Cheng Chiung-Mei Chen |
| author_facet | Hsiang-Yu Tang Daniel Tsun-yee Chiu Jui-Fen Lin Cheng-Yu Huang Kuo-Hsuan Chang Rong-Kuo Lyu Long-Sun Ro Hung-Chou Kuo Mei-Ling Cheng Chiung-Mei Chen |
| author_sort | Hsiang-Yu Tang |
| collection | DOAJ |
| description | Abstract Guillain-Barre Syndrome (GBS) is an inflammatory disease of the peripheral nervous system. Given that plasma metabolic profiles in GBS patients have never been explored, plasma samples of 38 GBS patients, 22 multiple sclerosis (MS) patients, and 40 healthy controls were analyzed by using untargeted and targeted metabolomics analysis. The untargeted analysis showed that levels of a set of plasma lipid metabolites were significantly decreased in GBS patients compared to the controls. Furthermore, the targeted analysis demonstrated that levels of 41 metabolites in GBS patients were significantly changed compared to either the controls or MS patients. A further metabolic analysis showed that 12 of 41 metabolites were significantly lower in classical GBS patients compared to Miller-Fisher syndrome. Among them, each of PCae C34:0, PCae C42:2, PCae C42:3, and SM C24:0 was inversely correlated with Hughes functional grading scale of GBS patients at both nadir and discharge. Receiver operating characteristic curve analysis of combination of three metabolites (PCaa C42:2, PCae C36:0 and SM C24:0) showed a good discrimination between the GBS and the controls (area under curve = 0.86). This study has demonstrated disruption of lipid metabolites in GBS may be potential biomarkers to indicate disease severity and prognosis of GBS. |
| first_indexed | 2024-12-19T02:46:23Z |
| format | Article |
| id | doaj.art-0e95220375774a9a99ff92ec8703f65d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T02:46:23Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0e95220375774a9a99ff92ec8703f65d2022-12-21T20:38:51ZengNature PortfolioScientific Reports2045-23222017-08-017111010.1038/s41598-017-08338-7Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre SyndromeHsiang-Yu Tang0Daniel Tsun-yee Chiu1Jui-Fen Lin2Cheng-Yu Huang3Kuo-Hsuan Chang4Rong-Kuo Lyu5Long-Sun Ro6Hung-Chou Kuo7Mei-Ling Cheng8Chiung-Mei Chen9Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung UniversityMetabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung UniversityMetabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung UniversityMetabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung UniversityDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung UniversityDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung UniversityDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung UniversityDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung UniversityMetabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung UniversityDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung UniversityAbstract Guillain-Barre Syndrome (GBS) is an inflammatory disease of the peripheral nervous system. Given that plasma metabolic profiles in GBS patients have never been explored, plasma samples of 38 GBS patients, 22 multiple sclerosis (MS) patients, and 40 healthy controls were analyzed by using untargeted and targeted metabolomics analysis. The untargeted analysis showed that levels of a set of plasma lipid metabolites were significantly decreased in GBS patients compared to the controls. Furthermore, the targeted analysis demonstrated that levels of 41 metabolites in GBS patients were significantly changed compared to either the controls or MS patients. A further metabolic analysis showed that 12 of 41 metabolites were significantly lower in classical GBS patients compared to Miller-Fisher syndrome. Among them, each of PCae C34:0, PCae C42:2, PCae C42:3, and SM C24:0 was inversely correlated with Hughes functional grading scale of GBS patients at both nadir and discharge. Receiver operating characteristic curve analysis of combination of three metabolites (PCaa C42:2, PCae C36:0 and SM C24:0) showed a good discrimination between the GBS and the controls (area under curve = 0.86). This study has demonstrated disruption of lipid metabolites in GBS may be potential biomarkers to indicate disease severity and prognosis of GBS.https://doi.org/10.1038/s41598-017-08338-7 |
| spellingShingle | Hsiang-Yu Tang Daniel Tsun-yee Chiu Jui-Fen Lin Cheng-Yu Huang Kuo-Hsuan Chang Rong-Kuo Lyu Long-Sun Ro Hung-Chou Kuo Mei-Ling Cheng Chiung-Mei Chen Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome Scientific Reports |
| title | Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome |
| title_full | Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome |
| title_fullStr | Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome |
| title_full_unstemmed | Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome |
| title_short | Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome |
| title_sort | disturbance of plasma lipid metabolic profile in guillain barre syndrome |
| url | https://doi.org/10.1038/s41598-017-08338-7 |
| work_keys_str_mv | AT hsiangyutang disturbanceofplasmalipidmetabolicprofileinguillainbarresyndrome AT danieltsunyeechiu disturbanceofplasmalipidmetabolicprofileinguillainbarresyndrome AT juifenlin disturbanceofplasmalipidmetabolicprofileinguillainbarresyndrome AT chengyuhuang disturbanceofplasmalipidmetabolicprofileinguillainbarresyndrome AT kuohsuanchang disturbanceofplasmalipidmetabolicprofileinguillainbarresyndrome AT rongkuolyu disturbanceofplasmalipidmetabolicprofileinguillainbarresyndrome AT longsunro disturbanceofplasmalipidmetabolicprofileinguillainbarresyndrome AT hungchoukuo disturbanceofplasmalipidmetabolicprofileinguillainbarresyndrome AT meilingcheng disturbanceofplasmalipidmetabolicprofileinguillainbarresyndrome AT chiungmeichen disturbanceofplasmalipidmetabolicprofileinguillainbarresyndrome |