HER2 positivity predicts BCG unresponsiveness and adaptive immune cell exhaustion in EORTC risk-stratified cohort of bladder cancer

HER2 positivity predicts BCG unresponsiveness and adaptive immune cell exhaustion in EORTC risk-stratified cohort of bladder cancer

IntroductionPredicting the response to Bacillus Calmette–Guérin (BCG) therapy in high-risk patients with non-muscle invasive bladder cancer (NMIBC) is crucial, as failure may necessitate interventions, such as radical cystectomy or salvage therapy. With the recent classification of genetic class 2a...

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Bibliographic Details
Main Authors: Wook Nam, Han Kyu Chae, Yeonuk Jung, Homin Kang, Myungchan Park, Ahnryul Choi, Jong Yeon Park, Dae-Woon Eom, Sung Jin Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
Bladder neoplasm
EORTC risk
Bacillus Calmette–Gúérin
HER2
ERBB2 mutation
T-cell exhaustion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1301510/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1301510/full

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