Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic Fevers
Viral hemorrhagic fevers (VHFs) caused by arenaviruses are acute diseases characterized by fever, headache, general malaise, impaired cellular immunity, eventual neurologic involvement, and hemostatic alterations that may ultimately lead to shock and death. The causes of the bleeding are still poorl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-01-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/5/1/340 |
| _version_ | 1818394553015599104 |
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| author | Roberto G. Pozner Ricardo M. Gómez Mirta Schattner Leonardo Rivadeneyra |
| author_facet | Roberto G. Pozner Ricardo M. Gómez Mirta Schattner Leonardo Rivadeneyra |
| author_sort | Roberto G. Pozner |
| collection | DOAJ |
| description | Viral hemorrhagic fevers (VHFs) caused by arenaviruses are acute diseases characterized by fever, headache, general malaise, impaired cellular immunity, eventual neurologic involvement, and hemostatic alterations that may ultimately lead to shock and death. The causes of the bleeding are still poorly understood. However, it is generally accepted that these causes are associated to some degree with impaired hemostasis, endothelial cell dysfunction and low platelet counts or function. In this article, we present the current knowledge about the hematological alterations present in VHF induced by arenaviruses, including new aspects on the underlying pathogenic mechanisms. |
| first_indexed | 2024-12-14T06:03:02Z |
| format | Article |
| id | doaj.art-0e9604e5a85041cf95090cc3380985e1 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-14T06:03:02Z |
| publishDate | 2013-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-0e9604e5a85041cf95090cc3380985e12022-12-21T23:14:22ZengMDPI AGViruses1999-49152013-01-015134035110.3390/v5010340Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic FeversRoberto G. PoznerRicardo M. GómezMirta SchattnerLeonardo RivadeneyraViral hemorrhagic fevers (VHFs) caused by arenaviruses are acute diseases characterized by fever, headache, general malaise, impaired cellular immunity, eventual neurologic involvement, and hemostatic alterations that may ultimately lead to shock and death. The causes of the bleeding are still poorly understood. However, it is generally accepted that these causes are associated to some degree with impaired hemostasis, endothelial cell dysfunction and low platelet counts or function. In this article, we present the current knowledge about the hematological alterations present in VHF induced by arenaviruses, including new aspects on the underlying pathogenic mechanisms.http://www.mdpi.com/1999-4915/5/1/340hemostasisendotheliumplateletsmegakaryocytescoagulationthrombocytopeniainterferonnitric oxide |
| spellingShingle | Roberto G. Pozner Ricardo M. Gómez Mirta Schattner Leonardo Rivadeneyra Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic Fevers Viruses hemostasis endothelium platelets megakaryocytes coagulation thrombocytopenia interferon nitric oxide |
| title | Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic Fevers |
| title_full | Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic Fevers |
| title_fullStr | Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic Fevers |
| title_full_unstemmed | Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic Fevers |
| title_short | Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic Fevers |
| title_sort | pathogenic mechanisms involved in the hematological alterations of arenavirus induced hemorrhagic fevers |
| topic | hemostasis endothelium platelets megakaryocytes coagulation thrombocytopenia interferon nitric oxide |
| url | http://www.mdpi.com/1999-4915/5/1/340 |
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