Introduction, Spread and Impact of the SARS-CoV-2 Omicron Variants BA.1 and BA.2 in Cyprus
The aim of this study was to investigate and obtain insights into the appearance, spread and impact of the Omicron variants and their sub-lineages in Cyprus by analyzing 611 high-coverage full-genome sequences for the period from November 2021 until April 2022. All viruses sequenced were identified...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/9/1688 |
| _version_ | 1827658642953863168 |
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| author | Jan Richter Dana Koptides Christina Tryfonos Denise Alexandrou Christina Christodoulou |
| author_facet | Jan Richter Dana Koptides Christina Tryfonos Denise Alexandrou Christina Christodoulou |
| author_sort | Jan Richter |
| collection | DOAJ |
| description | The aim of this study was to investigate and obtain insights into the appearance, spread and impact of the Omicron variants and their sub-lineages in Cyprus by analyzing 611 high-coverage full-genome sequences for the period from November 2021 until April 2022. All viruses sequenced were identified to belong to either Delta (B.1.617.2) or Omicron (lineage BA.1 and BA.2, respectively), with a variety of different sub-lineages. A detailed analysis of the mutational profile is presented and discussed. The Omicron variant BA.1 was shortly followed by BA.2; despite emerging against a background of high vaccination (81% of adult population) and pre-existing natural immunity, they gave rise to the largest waves of infection, with daily numbers rising dramatically, highlighting their increased ability for immune evasion. Within a period of only five months, the percentage of the Cypriot population with a confirmed infection increased from ~15% of the total population to >57%. Despite unprecedented case numbers, a significant reduction in hospital burden and mortality was observed. Our findings highlight the role of the importation of new variants through travel and demonstrate the importance of genomic surveillance in determining viral genetic diversity and the timely identification of new variants for guiding public health intervention measures. |
| first_indexed | 2024-03-09T23:06:33Z |
| format | Article |
| id | doaj.art-0e960718e03b4a4fb17ff44d7996e2b3 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T23:06:33Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-0e960718e03b4a4fb17ff44d7996e2b32023-11-23T17:51:32ZengMDPI AGMicroorganisms2076-26072022-08-01109168810.3390/microorganisms10091688Introduction, Spread and Impact of the SARS-CoV-2 Omicron Variants BA.1 and BA.2 in CyprusJan Richter0Dana Koptides1Christina Tryfonos2Denise Alexandrou3Christina Christodoulou4Molecular Virology Department, Cyprus Institute of Neurology and Genetics, Nicosia 2371, CyprusMolecular Virology Department, Cyprus Institute of Neurology and Genetics, Nicosia 2371, CyprusMolecular Virology Department, Cyprus Institute of Neurology and Genetics, Nicosia 2371, CyprusMedical and Public Health Services, Ministry of Health, Nicosia 1148, CyprusMolecular Virology Department, Cyprus Institute of Neurology and Genetics, Nicosia 2371, CyprusThe aim of this study was to investigate and obtain insights into the appearance, spread and impact of the Omicron variants and their sub-lineages in Cyprus by analyzing 611 high-coverage full-genome sequences for the period from November 2021 until April 2022. All viruses sequenced were identified to belong to either Delta (B.1.617.2) or Omicron (lineage BA.1 and BA.2, respectively), with a variety of different sub-lineages. A detailed analysis of the mutational profile is presented and discussed. The Omicron variant BA.1 was shortly followed by BA.2; despite emerging against a background of high vaccination (81% of adult population) and pre-existing natural immunity, they gave rise to the largest waves of infection, with daily numbers rising dramatically, highlighting their increased ability for immune evasion. Within a period of only five months, the percentage of the Cypriot population with a confirmed infection increased from ~15% of the total population to >57%. Despite unprecedented case numbers, a significant reduction in hospital burden and mortality was observed. Our findings highlight the role of the importation of new variants through travel and demonstrate the importance of genomic surveillance in determining viral genetic diversity and the timely identification of new variants for guiding public health intervention measures.https://www.mdpi.com/2076-2607/10/9/1688SARS-CoV-2COVID-19Omicronwhole-genome sequencingepidemiologyCyprus |
| spellingShingle | Jan Richter Dana Koptides Christina Tryfonos Denise Alexandrou Christina Christodoulou Introduction, Spread and Impact of the SARS-CoV-2 Omicron Variants BA.1 and BA.2 in Cyprus Microorganisms SARS-CoV-2 COVID-19 Omicron whole-genome sequencing epidemiology Cyprus |
| title | Introduction, Spread and Impact of the SARS-CoV-2 Omicron Variants BA.1 and BA.2 in Cyprus |
| title_full | Introduction, Spread and Impact of the SARS-CoV-2 Omicron Variants BA.1 and BA.2 in Cyprus |
| title_fullStr | Introduction, Spread and Impact of the SARS-CoV-2 Omicron Variants BA.1 and BA.2 in Cyprus |
| title_full_unstemmed | Introduction, Spread and Impact of the SARS-CoV-2 Omicron Variants BA.1 and BA.2 in Cyprus |
| title_short | Introduction, Spread and Impact of the SARS-CoV-2 Omicron Variants BA.1 and BA.2 in Cyprus |
| title_sort | introduction spread and impact of the sars cov 2 omicron variants ba 1 and ba 2 in cyprus |
| topic | SARS-CoV-2 COVID-19 Omicron whole-genome sequencing epidemiology Cyprus |
| url | https://www.mdpi.com/2076-2607/10/9/1688 |
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