Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

Ubiquitin-dependent proteolysis can initiate at ribosomes for myriad reasons including misfolding of a nascent chain or stalling of the ribosome during translation of mRNA. Clearance of a stalled complex is required to recycle the ribosome for future use. Here we show that the ubiquitin (Ub) pathway...

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Bibliographic Details
Main Authors: Rati Verma, Robert S Oania, Natalie J Kolawa, Raymond J Deshaies
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-01-01
Series:eLife
Subjects:
ubiquitin
ribosome
Cdc48
Online Access:https://elifesciences.org/articles/00308

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