Depletion of Na<sup>+</sup>/H<sup>+</sup> Exchanger Isoform 1 Increases the Host Cell Resistance to <i>Trypanosoma cruzi</i> Invasion

Depletion of Na<sup>+</sup>/H<sup>+</sup> Exchanger Isoform 1 Increases the Host Cell Resistance to <i>Trypanosoma cruzi</i> Invasion

Na<sup>+</sup>/H<sup>+</sup> exchanger isoform 1 (NHE1), a member of a large family of integral membrane proteins, plays a role in regulating the cortical actin cytoskeleton. <i>Trypanosoma cruzi</i>, the agent of Chagas disease, depends on F-actin rearrangement a...

Full description

Bibliographic Details
Main Authors:	João Paulo Ferreira Rodrigues, Leonardo Loch, Thiago Souza Onofre, Nobuko Yoshida
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Series:	Pathogens
Subjects:	<i>Trypanosoma cruzi</i> Na<sup>+</sup>/H<sup>+</sup> exchanger isoform 1 host cell invasion metacyclic trypomastigote
Online Access:	https://www.mdpi.com/2076-0817/11/11/1294

Similar Items

After Experimental <i>Trypanosoma cruzi</i> Infection, Dying Hepatic CD3<sup>+</sup>TCRαβ<sup>+</sup>B220<sup>+</sup> T Lymphocytes Are Rescued from Death by Peripheral T Cells and Become Activated
by: Natalia Vacani-Martins, et al.
Published: (2020-08-01)

Na<sup>+</sup>,K<sup>+</sup>-ATPase with Disrupted Na<sup>+</sup> Binding Sites I and III Binds Na<sup>+</sup> with Increased Affinity at Site II and Undergoes Na<sup>+</sup>-Activated Phosphorylation with ATP
by: Hang N. Nielsen, et al.
Published: (2024-01-01)

Hypercontractile Cardiac Phenotype in Mice with Migraine-Associated Mutation in the Na<sup>+</sup>,K<sup>+</sup>-ATPase α<sub>2</sub>-Isoform
by: Rajkumar Rajanathan, et al.
Published: (2023-04-01)

Heterotridentate Organomonophosphines in Pt(κ<sup>3</sup>–X<sup>1</sup>P<sup>1</sup>X<sup>2</sup>)(Y) (X<sup>1,2</sup> = N<sup>1,2</sup> or S<sup>1,2</sup>), Pt(κ<sup>3</sup>–P<sup>1</sup>N<sup>1</sup>X<sup>1</sup>)(Y) (X<sup>1</sup> = O, C, S or Se) Pt(κ<sup>3</sup>–P<sup>1</sup>S<sup>1</sup>Cl<sup>1</sup>)(Cl) and Pt(κ<sup>3</sup>–P<sup>1</sup>Si<sup>1</sup>N<sup>1</sup>)(OL)—Structural Aspects
by: Milan Melník, et al.
Published: (2022-12-01)

Comparative study of serum Na<sup>+ </sup>and K<sup>+ </sup> levels in senile cataract patients and normal individuals
Published: (2004-08-01)

Spinach Plants Favor the Absorption of K<sup>+</sup> over Na<sup>+</sup> Regardless of Salinity, and May Benefit from Na<sup>+</sup> When K<sup>+</sup> is Deficient in the Soil
by: Jorge F. S. Ferreira, et al.
Published: (2020-04-01)

Ontogenetic Development of Gill and Na<sup>+</sup>/K<sup>+</sup> ATPase in the Air-Breathing Loach
by: Yaqiu Liu, et al.
Published: (2022-12-01)

Na<sup>+</sup> Binding and Transport: Insights from Light-Driven Na<sup>+</sup>-Pumping Rhodopsin
by: Qifan Yang, et al.
Published: (2023-10-01)

Transcriptomic changes across the life cycle of Trypanosoma cruzi II
by: Lissa Cruz-Saavedra, et al.
Published: (2020-05-01)

Safranal Induces Vasorelaxation by Inhibiting Ca<sup>2+</sup> Influx and Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger in Isolated Rat Aortic Rings
by: Noor Nadhim Al-Saigh, et al.
Published: (2022-06-01)

Embracing [XY<sub>3</sub>]<i><sup>m–</sup></i> and [XY<sub>4</sub>]<i><sup>m–</sup></i> Anions in Salts of [M(bpy)<sub>3</sub>]<i><sup>q</sup></i><sup>+</sup>
by: Edwin C. Constable, et al.
Published: (2023-01-01)

A Thermal Sublimation Generator of <sup>131m</sup>Xe
by: Karolina Kulesz, et al.
Published: (2022-11-01)

Effects of Sesamin, the Major Furofuran Lignan of Sesame Oil, on the Amplitude and Gating of Voltage-Gated Na<sup>+</sup> and K<sup>+</sup> Currents
by: Ping-Chung Kuo, et al.
Published: (2020-07-01)

Measurement of Aβ Amyloid Plaques and Tau Protein in Postmortem Human Alzheimer’s Disease Brain by Autoradiography Using [<sup>18</sup>F]Flotaza, [<sup>125</sup>I]IBETA, [<sup>124/125</sup>I]IPPI and Immunohistochemistry Analysis Using QuPath
by: Rommani Mondal, et al.
Published: (2023-03-01)

The Kauffman Bracket Skein Module of <i>S</i><sup>1</sup> × <i>S</i><sup>2</sup> via Braids
by: Ioannis Diamantis
Published: (2024-09-01)

Physiological and Pathophysiological Roles of Mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> Exchanger, NCLX, in Hearts
by: Ayako Takeuchi, et al.
Published: (2021-12-01)

Comparative Na<sup>+</sup> and K<sup>+</sup> Profiling Reveals Microbial Community Assembly of Alfalfa Silage in Different Saline-Alkali Soils
by: Shengnan Li, et al.
Published: (2023-09-01)

Interaction of (+)-Strebloside and Its Derivatives with Na<sup>+</sup>/K<sup>+</sup>-ATPase and Other Targets
by: Yulin Ren, et al.
Published: (2021-09-01)

The Effect of Decreased Ca<sup>++</sup>/Mg<sup>++</sup> ATPase Activity on <i>Lactobacillus delbrueckii</i> subsp. <i>bulgaricus</i> sp1.1 Survival during Spray Drying
by: Jialei Sun, et al.
Published: (2023-02-01)

Organomonophosphines in Pt(η<sup>3</sup>-X<sup>1</sup>X<sup>2</sup>X<sup>3</sup>)(PR<sub>3</sub>), (X = N<sup>1</sup>, N<sup>2</sup>, N<sup>3</sup>; S<sup>1</sup>, S<sup>2</sup>, S<sup>3</sup>; or Te<sup>1</sup>, Te<sup>2</sup>, Te<sup>3</sup>) Derivatives: Structural Aspects
by: Milan Melník, et al.
Published: (2023-06-01)

Protection and Safety Evaluation of Live Constructions Derived from the Pgm<sup>−</sup> and pPCP1<sup>−</sup> <i>Yersinia pestis</i> Strain
by: Xiuran Wang, et al.
Published: (2020-02-01)

The Pseudo-Protic Ionic Liquids TOAH<sup>+</sup>Cl<sup>−</sup> and TODAH<sup>+</sup>Cl<sup>−</sup> as Carriers for Facilitated Transport of In(III) from HCl Solutions
by: Francisco José Alguacil, et al.
Published: (2022-12-01)

S-ABA Enhances Rice Salt Tolerance by Regulating Na<sup>+</sup>/K<sup>+</sup> Balance and Hormone Homeostasis
by: Wenxin Jiang, et al.
Published: (2024-03-01)

SAR296968, a Novel Selective Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger Inhibitor, Improves Ca<sup>2+</sup> Handling and Contractile Function in Human Atrial Cardiomyocytes
by: Philipp Hegner, et al.
Published: (2022-08-01)

Na<sup>+</sup>,K<sup>+</sup>-ATPase and Cardiotonic Steroids in Models of Dopaminergic System Pathologies
by: Alisa A. Markina, et al.
Published: (2023-06-01)

Semipermeable Mixed Phospholipid-Fatty Acid Membranes Exhibit K<sup>+</sup>/Na<sup>+</sup> Selectivity in the Absence of Proteins
by: Xianfeng Zhou, et al.
Published: (2020-04-01)

NH<sub>4</sub><sup>+</sup> Toxicity, Which Is Mainly Determined by the High NH<sub>4</sub><sup>+</sup>/K<sup>+</sup> Ratio, Is Alleviated by CIPK23 in <i>Arabidopsis</i>
by: Sujuan Shi, et al.
Published: (2020-04-01)

Structural Insights into the Interactions of Digoxin and Na<sup>+</sup>/K<sup>+</sup>-ATPase and Other Targets for the Inhibition of Cancer Cell Proliferation
by: Yulin Ren, et al.
Published: (2021-06-01)

Transcription Factors Mcm1 and Sfp1 May Affect [<i>PSI</i><sup>+</sup>] Prion Phenotype by Altering the Expression of the <i>SUP35</i> Gene
by: Andrew G. Matveenko, et al.
Published: (2024-04-01)

Effects of Short-Term Salinity Stress on Ions, Free Amino Acids, Na<sup>+</sup>/K<sup>+</sup>-ATPase Activity, and Gill Histology in the Threatened Freshwater Shellfish <i>Solenaia oleivora</i>
by: Ting Zhang, et al.
Published: (2022-11-01)

Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose<sup>®</sup> 80, CombiLac<sup>®</sup>, MicroceLac<sup>®</sup> 100, and StarLac<sup>®</sup>
by: Martin Dominik, et al.
Published: (2021-09-01)

Targeting PirA<i><sup>vp</sup></i> and PirB<i><sup>vp</sup></i> Toxins of <i>Vibrio parahaemolyticus</i> with Oilseed Peptides: An In Silico Approach
by: Joe-Hui Ong, et al.
Published: (2021-10-01)

Phase I and II Clinical Trial Comparing the LBSap, Leishmune<sup>®</sup>, and Leish-Tec<sup>®</sup> Vaccines against Canine Visceral Leishmaniasis
by: Rodrigo Dian de Oliveira Aguiar-Soares, et al.
Published: (2020-11-01)

K<sup>+</sup> and Ca<sup>2+</sup> Channels Regulate Ca<sup>2+</sup> Signaling in Chondrocytes: An Illustrated Review
by: Yoshiaki Suzuki, et al.
Published: (2020-06-01)

Phototactic Changes in <i>Phthorimaea absoluta</i> Long-Wavelength Opsin Gene Mutants (<i>LW2<sup>−/−</sup></i>) and Short-Wavelength Opsin Gene Mutant (<i>BL<sup>−/−</sup></i>) Strains
by: Yanhong Tang, et al.
Published: (2024-06-01)

Characterization of Stimulatory Action on Voltage-Gated Na<sup>+</sup> Currents Caused by Omecamtiv Mecarbil, Known to Be a Myosin Activator
by: Chih-Yu Ting, et al.
Published: (2023-05-01)

Recent Advances in the Study of Na<sup>+</sup>/K<sup>+</sup>-ATPase in Neurodegenerative Diseases
by: Xiaoyan Zhang, et al.
Published: (2022-12-01)

The Sweet Potato K<sup>+</sup> Transporter IbHAK11 Regulates K<sup>+</sup> Deficiency and High Salinity Stress Tolerance by Maintaining Positive Ion Homeostasis
by: Hong Zhu, et al.
Published: (2023-06-01)

A DFT Study on Fe<sup>I</sup>/Fe<sup>II</sup>/Fe<sup>III</sup> Mechanism of the Cross-Coupling between Haloalkane and Aryl Grignard Reagent Catalyzed by Iron-SciOPP Complexes
by: Akhilesh K. Sharma, et al.
Published: (2020-08-01)

Quality Assurance Investigations and Impurity Characterization during Upscaling of [<sup>177</sup>Lu]Lu-PSMA<sup>I&T</sup>
by: Stefan Schmitl, et al.
Published: (2023-11-01)