Biological Applications of Thiocarbohydrazones and Their Metal Complexes: A Perspective Review
Although organic compounds account for more than 99% of currently approved clinical drugs, the established clinical use of cisplatin in cancer or auranofin in rheumatoid arthritis have paved the way to several research initiatives to identify metal-based drugs for a wide range of human diseases. Nit...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-12-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/13/1/4 |
| _version_ | 1818911420933210112 |
|---|---|
| author | Carmela Bonaccorso Tiziano Marzo Diego La Mendola |
| author_facet | Carmela Bonaccorso Tiziano Marzo Diego La Mendola |
| author_sort | Carmela Bonaccorso |
| collection | DOAJ |
| description | Although organic compounds account for more than 99% of currently approved clinical drugs, the established clinical use of cisplatin in cancer or auranofin in rheumatoid arthritis have paved the way to several research initiatives to identify metal-based drugs for a wide range of human diseases. Nitrogen and sulfur donor ligands, characterized by different binding motifs, have been the subject in recent years of one of the main research areas in coordination chemistry. Among the nitrogen/sulfur compounds, very little is known about thiocarbohydrazones (TCH), the higher homologues of the well-known thiosemicarbazones (TSC), and their metal complexes. The extra hydrazine moiety provides the ligands of variable metal binding modes, structural diversity and promising biological implications. The interesting coordination chemistry of TCH has mainly been focused on symmetric derivatives, which are relatively simple to synthesize while few examples of asymmetric ligands have been reported. This informative review on TCHs and their metal complexes will be helpful for improving the design of metal-based pharmaceuticals for applications ranging from anticancer to antinfective therapy. |
| first_indexed | 2024-12-19T22:58:25Z |
| format | Article |
| id | doaj.art-0e9b10779ea345ecb3934e8b022efe41 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-12-19T22:58:25Z |
| publishDate | 2019-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-0e9b10779ea345ecb3934e8b022efe412022-12-21T20:02:33ZengMDPI AGPharmaceuticals1424-82472019-12-01131410.3390/ph13010004ph13010004Biological Applications of Thiocarbohydrazones and Their Metal Complexes: A Perspective ReviewCarmela Bonaccorso0Tiziano Marzo1Diego La Mendola2Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, 95125 Catania, ItalyDipartimento di Farmacia, Università di Pisa, Via Bonanno Pisano 6, 56126 Pisa, ItalyDipartimento di Farmacia, Università di Pisa, Via Bonanno Pisano 6, 56126 Pisa, ItalyAlthough organic compounds account for more than 99% of currently approved clinical drugs, the established clinical use of cisplatin in cancer or auranofin in rheumatoid arthritis have paved the way to several research initiatives to identify metal-based drugs for a wide range of human diseases. Nitrogen and sulfur donor ligands, characterized by different binding motifs, have been the subject in recent years of one of the main research areas in coordination chemistry. Among the nitrogen/sulfur compounds, very little is known about thiocarbohydrazones (TCH), the higher homologues of the well-known thiosemicarbazones (TSC), and their metal complexes. The extra hydrazine moiety provides the ligands of variable metal binding modes, structural diversity and promising biological implications. The interesting coordination chemistry of TCH has mainly been focused on symmetric derivatives, which are relatively simple to synthesize while few examples of asymmetric ligands have been reported. This informative review on TCHs and their metal complexes will be helpful for improving the design of metal-based pharmaceuticals for applications ranging from anticancer to antinfective therapy.https://www.mdpi.com/1424-8247/13/1/4thiocarbohydrazonesmetallodrugsanticancerantimicrobialmetal ions |
| spellingShingle | Carmela Bonaccorso Tiziano Marzo Diego La Mendola Biological Applications of Thiocarbohydrazones and Their Metal Complexes: A Perspective Review Pharmaceuticals thiocarbohydrazones metallodrugs anticancer antimicrobial metal ions |
| title | Biological Applications of Thiocarbohydrazones and Their Metal Complexes: A Perspective Review |
| title_full | Biological Applications of Thiocarbohydrazones and Their Metal Complexes: A Perspective Review |
| title_fullStr | Biological Applications of Thiocarbohydrazones and Their Metal Complexes: A Perspective Review |
| title_full_unstemmed | Biological Applications of Thiocarbohydrazones and Their Metal Complexes: A Perspective Review |
| title_short | Biological Applications of Thiocarbohydrazones and Their Metal Complexes: A Perspective Review |
| title_sort | biological applications of thiocarbohydrazones and their metal complexes a perspective review |
| topic | thiocarbohydrazones metallodrugs anticancer antimicrobial metal ions |
| url | https://www.mdpi.com/1424-8247/13/1/4 |
| work_keys_str_mv | AT carmelabonaccorso biologicalapplicationsofthiocarbohydrazonesandtheirmetalcomplexesaperspectivereview AT tizianomarzo biologicalapplicationsofthiocarbohydrazonesandtheirmetalcomplexesaperspectivereview AT diegolamendola biologicalapplicationsofthiocarbohydrazonesandtheirmetalcomplexesaperspectivereview |