HBV Drug Resistance Substitutions Existed before the Clinical Approval of Nucleos(t)ide Analogues: A Bioinformatic Analysis by GenBank Data Mining

HBV Drug Resistance Substitutions Existed before the Clinical Approval of Nucleos(t)ide Analogues: A Bioinformatic Analysis by GenBank Data Mining

Naturally occurring nucleos(t)ide analogue resistance (NUCr) substitution frequencies in the reverse transcriptase (RT) of the hepatitis B virus (HBV) were studied extensively after the clinical approval of nucleos(t)ide analogues (NUCs; year of approval 1998). We aimed to study NUCr substitutions i...

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Bibliographic Details
Main Authors: Xizhan Xu, Kuanhui Xiang, Mingze Su, Yao Li, Wei Ji, Yutang Li, Hui Zhuang, Tong Li
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Viruses
Subjects:
hepatitis B virus
reverse transcriptase
nucleos(t)ides analogue resistance
substitution
pre-existing
naturally occurring
Online Access:https://www.mdpi.com/1999-4915/9/8/199

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