The prognostic role of urea-to-creatinine ratio in patients with acute heart failure syndrome: a case–control study
Abstract Background Recent research has shown that the blood urea/creatinine ratio (BUN/Cr) rather than BUN or Cr alone can predict the prognosis of individuals with acute heart failure (AHF). The objective of this study was to estimate the urea-to creatinine serum ratio (BUN/Cr) in patients with ac...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-09-01
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| Series: | The Egyptian Heart Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43044-023-00404-y |
| _version_ | 1797558777402097664 |
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| author | Ahmed Refaat Mohamed Sakr Gamal Fahim Elsayed Gomaa Salwa Mahmoud El Wasif Ahmed Hassan Hosny Eladawy |
| author_facet | Ahmed Refaat Mohamed Sakr Gamal Fahim Elsayed Gomaa Salwa Mahmoud El Wasif Ahmed Hassan Hosny Eladawy |
| author_sort | Ahmed Refaat Mohamed Sakr |
| collection | DOAJ |
| description | Abstract Background Recent research has shown that the blood urea/creatinine ratio (BUN/Cr) rather than BUN or Cr alone can predict the prognosis of individuals with acute heart failure (AHF). The objective of this study was to estimate the urea-to creatinine serum ratio (BUN/Cr) in patients with acute decompensated heart failure (ADHF) and correlate the results with patient outcome, length of hospitalization, and mortality. Results Sixty ADHF patients were included and categorized into four groups; Group I: non-AKI with low BUN/Cr (n = 25); Group II: non-AKI with high BUN/Cr (n = 5); Group III: AKI with low BUN/Cr (n = 14); Group IV: AKI with high BUN/Cr (n = 16). Regarding urea and BUN levels, the first reading showed a considerable rise in urea and BUN levels in groups III and IV compared to group 1 and in group IV compared to groups I and III. Similar results were recorded in the second and third readings. Regarding the BUN/Cr ratio, the three readings revealed a significant elevation in group IV compared to groups I and II and in group IV compared to group III. Mortality was significantly higher in group IV compared to group I. Additionally, MACE was significantly more frequent in group IV compared to groups I and III. Multivariable logistic regression analysis revealed that hypertension, creatinine, and BUN were independent predictors of AKI. Conclusions BUN/Cr may predict prognosis in AHF patients since AHF with an elevated BUN/Cr is associated with a higher death rate. |
| first_indexed | 2024-03-10T17:36:11Z |
| format | Article |
| id | doaj.art-0e9bf93c03ba4c18bc1ed439966cc8b9 |
| institution | Directory Open Access Journal |
| issn | 2090-911X |
| language | English |
| last_indexed | 2024-03-10T17:36:11Z |
| publishDate | 2023-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj.art-0e9bf93c03ba4c18bc1ed439966cc8b92023-11-20T09:49:59ZengSpringerOpenThe Egyptian Heart Journal2090-911X2023-09-017511910.1186/s43044-023-00404-yThe prognostic role of urea-to-creatinine ratio in patients with acute heart failure syndrome: a case–control studyAhmed Refaat Mohamed Sakr0Gamal Fahim Elsayed Gomaa1Salwa Mahmoud El Wasif2Ahmed Hassan Hosny Eladawy3Faculty of Medicine, Mansoura UniversityFaculty of Medicine, Mansoura UniversityFaculty of Medicine, Mansoura UniversityFaculty of Medicine, Mansoura UniversityAbstract Background Recent research has shown that the blood urea/creatinine ratio (BUN/Cr) rather than BUN or Cr alone can predict the prognosis of individuals with acute heart failure (AHF). The objective of this study was to estimate the urea-to creatinine serum ratio (BUN/Cr) in patients with acute decompensated heart failure (ADHF) and correlate the results with patient outcome, length of hospitalization, and mortality. Results Sixty ADHF patients were included and categorized into four groups; Group I: non-AKI with low BUN/Cr (n = 25); Group II: non-AKI with high BUN/Cr (n = 5); Group III: AKI with low BUN/Cr (n = 14); Group IV: AKI with high BUN/Cr (n = 16). Regarding urea and BUN levels, the first reading showed a considerable rise in urea and BUN levels in groups III and IV compared to group 1 and in group IV compared to groups I and III. Similar results were recorded in the second and third readings. Regarding the BUN/Cr ratio, the three readings revealed a significant elevation in group IV compared to groups I and II and in group IV compared to group III. Mortality was significantly higher in group IV compared to group I. Additionally, MACE was significantly more frequent in group IV compared to groups I and III. Multivariable logistic regression analysis revealed that hypertension, creatinine, and BUN were independent predictors of AKI. Conclusions BUN/Cr may predict prognosis in AHF patients since AHF with an elevated BUN/Cr is associated with a higher death rate.https://doi.org/10.1186/s43044-023-00404-yUrea-to-creatinine ratioAcute heart failureAcute kidney injuryPrognosis |
| spellingShingle | Ahmed Refaat Mohamed Sakr Gamal Fahim Elsayed Gomaa Salwa Mahmoud El Wasif Ahmed Hassan Hosny Eladawy The prognostic role of urea-to-creatinine ratio in patients with acute heart failure syndrome: a case–control study The Egyptian Heart Journal Urea-to-creatinine ratio Acute heart failure Acute kidney injury Prognosis |
| title | The prognostic role of urea-to-creatinine ratio in patients with acute heart failure syndrome: a case–control study |
| title_full | The prognostic role of urea-to-creatinine ratio in patients with acute heart failure syndrome: a case–control study |
| title_fullStr | The prognostic role of urea-to-creatinine ratio in patients with acute heart failure syndrome: a case–control study |
| title_full_unstemmed | The prognostic role of urea-to-creatinine ratio in patients with acute heart failure syndrome: a case–control study |
| title_short | The prognostic role of urea-to-creatinine ratio in patients with acute heart failure syndrome: a case–control study |
| title_sort | prognostic role of urea to creatinine ratio in patients with acute heart failure syndrome a case control study |
| topic | Urea-to-creatinine ratio Acute heart failure Acute kidney injury Prognosis |
| url | https://doi.org/10.1186/s43044-023-00404-y |
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