RHAMM-target peptides inhibit invasion of breast cancer cells
RHAMM is hyaluronan- receptor with multiple functions in the cell, RHAMM is involved in proliferation, motility, migration, invasion, mitotic spindle formation in tumour cells. Therefore, RHAMM could be a relevant target for molecular targeted therapies against tumors.The role of RHAMM-target peptid...
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2017-05-01
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| Series: | The EuroBiotech Journal |
| Online Access: | https://doi.org/10.24190/ISSN2564-615X/2017/02.05 |
| _version_ | 1819143705453395968 |
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| author | Akentieva Natalia |
| author_facet | Akentieva Natalia |
| author_sort | Akentieva Natalia |
| collection | DOAJ |
| description | RHAMM is hyaluronan- receptor with multiple functions in the cell, RHAMM is involved in proliferation, motility, migration, invasion, mitotic spindle formation in tumour cells. Therefore, RHAMM could be a relevant target for molecular targeted therapies against tumors.The role of RHAMM-target peptides in inhibition invasion for preventing breast cancer has not yet been investigated. Base on this, we analyzed the RHAMM-target peptides for their therapeutic activity against breast cancer cells. In the present study, we examined the effect of RHAMM-target peptides on the invasion of breast cancer cells (MDAMB- 231), using confocal microscopy. We shown that RHAMM-target peptides decreased formation of invadopodia of breast cancer cells. The treatment of breast cancer cells by RHAMM -target peptides inhibited the invasion up to 99 %. Additionally, RHAMM-target peptides induced the morphological changes of of breast cancer cells. Therefore, based on these results, we can conclude that RHAMM-target peptides may be potential anti-cancer agents. |
| first_indexed | 2024-12-22T12:30:29Z |
| format | Article |
| id | doaj.art-0e9ca771252a45eb87ca111d4864bc69 |
| institution | Directory Open Access Journal |
| issn | 2564-615X |
| language | English |
| last_indexed | 2024-12-22T12:30:29Z |
| publishDate | 2017-05-01 |
| publisher | Sciendo |
| record_format | Article |
| series | The EuroBiotech Journal |
| spelling | doaj.art-0e9ca771252a45eb87ca111d4864bc692022-12-21T18:25:40ZengSciendoThe EuroBiotech Journal2564-615X2017-05-011213814810.24190/ISSN2564-615X/2017/02.05RHAMM-target peptides inhibit invasion of breast cancer cellsAkentieva Natalia0Kinetics Chemical and Biological Processes; Institute problems of Chemical Physics RAS, pr.acad. Semenova, 1 Chernogolovka Moscow, Russian FederationRHAMM is hyaluronan- receptor with multiple functions in the cell, RHAMM is involved in proliferation, motility, migration, invasion, mitotic spindle formation in tumour cells. Therefore, RHAMM could be a relevant target for molecular targeted therapies against tumors.The role of RHAMM-target peptides in inhibition invasion for preventing breast cancer has not yet been investigated. Base on this, we analyzed the RHAMM-target peptides for their therapeutic activity against breast cancer cells. In the present study, we examined the effect of RHAMM-target peptides on the invasion of breast cancer cells (MDAMB- 231), using confocal microscopy. We shown that RHAMM-target peptides decreased formation of invadopodia of breast cancer cells. The treatment of breast cancer cells by RHAMM -target peptides inhibited the invasion up to 99 %. Additionally, RHAMM-target peptides induced the morphological changes of of breast cancer cells. Therefore, based on these results, we can conclude that RHAMM-target peptides may be potential anti-cancer agents.https://doi.org/10.24190/ISSN2564-615X/2017/02.05 |
| spellingShingle | Akentieva Natalia RHAMM-target peptides inhibit invasion of breast cancer cells The EuroBiotech Journal |
| title | RHAMM-target peptides inhibit invasion of breast cancer cells |
| title_full | RHAMM-target peptides inhibit invasion of breast cancer cells |
| title_fullStr | RHAMM-target peptides inhibit invasion of breast cancer cells |
| title_full_unstemmed | RHAMM-target peptides inhibit invasion of breast cancer cells |
| title_short | RHAMM-target peptides inhibit invasion of breast cancer cells |
| title_sort | rhamm target peptides inhibit invasion of breast cancer cells |
| url | https://doi.org/10.24190/ISSN2564-615X/2017/02.05 |
| work_keys_str_mv | AT akentievanatalia rhammtargetpeptidesinhibitinvasionofbreastcancercells |