A ginger extract improves ocular blood flow in rats with endothelin-induced retinal blood flow dysfunction
Abstract The aim of this study was to investigate the effect of a ginger extract on optic nerve head blood flow (ONH BF) under endothelin-1 (ET-1) stimulation. Using laser speckle flowgraphy, we measured ONH BF in brown Norway rats. To establish the ONH BF impairment profile under ET-1 stimulation,...
| Main Authors: | , , , , , |
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| Format: | Article |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-49598-w |
| _version_ | 1797376955596668928 |
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| author | Nana Takahashi Kota Sato Naoki Kiyota Satoru Tsuda Namie Murayama Toru Nakazawa |
| author_facet | Nana Takahashi Kota Sato Naoki Kiyota Satoru Tsuda Namie Murayama Toru Nakazawa |
| author_sort | Nana Takahashi |
| collection | DOAJ |
| description | Abstract The aim of this study was to investigate the effect of a ginger extract on optic nerve head blood flow (ONH BF) under endothelin-1 (ET-1) stimulation. Using laser speckle flowgraphy, we measured ONH BF in brown Norway rats. To establish the ONH BF impairment profile under ET-1 stimulation, we administered an intravitreal injection of ET-1 under anesthesia. We then gave the ginger extract sublingually to assess its effect on ONH BF in both normal and ET-1-induced ischemic conditions. Post ET-1 injection, there were no significant changes in parameters including intraocular pressure or systemic factors. ONH BF showed a dose-dependent decline after ET-1 injection, with a significant reduction after a 2.50 pmol ET-1 dose. Sublingual administration of the ginger extract significantly improved ONH BF in both normal and ET-1-stimulated rats. This suggests that our newly developed supplement for improving ONH BF has a potential role in retinal ischemic diseases, including glaucoma. |
| first_indexed | 2024-03-08T19:47:02Z |
| format | Article |
| id | doaj.art-0e9ceac9c75640449dde30301ed91b02 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T19:47:02Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0e9ceac9c75640449dde30301ed91b022023-12-24T12:17:56ZengNature PortfolioScientific Reports2045-23222023-12-011311810.1038/s41598-023-49598-wA ginger extract improves ocular blood flow in rats with endothelin-induced retinal blood flow dysfunctionNana Takahashi0Kota Sato1Naoki Kiyota2Satoru Tsuda3Namie Murayama4Toru Nakazawa5Department of Ophthalmology, Tohoku University Graduate School of MedicineDepartment of Ophthalmology, Tohoku University Graduate School of MedicineDepartment of Ophthalmology, Tohoku University Graduate School of MedicineDepartment of Ophthalmology, Tohoku University Graduate School of MedicineDepartment of Ophthalmology, Tohoku University Graduate School of MedicineDepartment of Ophthalmology, Tohoku University Graduate School of MedicineAbstract The aim of this study was to investigate the effect of a ginger extract on optic nerve head blood flow (ONH BF) under endothelin-1 (ET-1) stimulation. Using laser speckle flowgraphy, we measured ONH BF in brown Norway rats. To establish the ONH BF impairment profile under ET-1 stimulation, we administered an intravitreal injection of ET-1 under anesthesia. We then gave the ginger extract sublingually to assess its effect on ONH BF in both normal and ET-1-induced ischemic conditions. Post ET-1 injection, there were no significant changes in parameters including intraocular pressure or systemic factors. ONH BF showed a dose-dependent decline after ET-1 injection, with a significant reduction after a 2.50 pmol ET-1 dose. Sublingual administration of the ginger extract significantly improved ONH BF in both normal and ET-1-stimulated rats. This suggests that our newly developed supplement for improving ONH BF has a potential role in retinal ischemic diseases, including glaucoma.https://doi.org/10.1038/s41598-023-49598-w |
| spellingShingle | Nana Takahashi Kota Sato Naoki Kiyota Satoru Tsuda Namie Murayama Toru Nakazawa A ginger extract improves ocular blood flow in rats with endothelin-induced retinal blood flow dysfunction Scientific Reports |
| title | A ginger extract improves ocular blood flow in rats with endothelin-induced retinal blood flow dysfunction |
| title_full | A ginger extract improves ocular blood flow in rats with endothelin-induced retinal blood flow dysfunction |
| title_fullStr | A ginger extract improves ocular blood flow in rats with endothelin-induced retinal blood flow dysfunction |
| title_full_unstemmed | A ginger extract improves ocular blood flow in rats with endothelin-induced retinal blood flow dysfunction |
| title_short | A ginger extract improves ocular blood flow in rats with endothelin-induced retinal blood flow dysfunction |
| title_sort | ginger extract improves ocular blood flow in rats with endothelin induced retinal blood flow dysfunction |
| url | https://doi.org/10.1038/s41598-023-49598-w |
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