How Single Amino Acid Substitutions Can Disrupt a Protein Hetero-Dimer Interface: Computational and Experimental Studies of the LigAB Dioxygenase from <i>Sphingobium</i> sp. Strain SYK-6
Protocatechuate 4,5-dioxygenase (LigAB) is a heterodimeric enzyme that catalyzes the dioxygenation of multiple lignin derived aromatic compounds. The active site of LigAB is at the heterodimeric interface, with specificity conferred by the alpha subunit and catalytic residues contributed by the beta...
Main Authors: | Angelika Rafalowski, Bakar A. Hassan, Kate Lou, Minh Chau Nguyen, Erika A. Taylor |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-03-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/24/7/6319 |
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