Long-Term Enhancement of NMDA Receptor Function in Inhibitory Neurons Preferentially Modulates Potassium Channels and Cell Adhesion Molecules

Long-Term Enhancement of NMDA Receptor Function in Inhibitory Neurons Preferentially Modulates Potassium Channels and Cell Adhesion Molecules

Effectively enhancing the activity of inhibitory neurons has great therapeutic potentials since their reduced function/activity has significant contributions to pathology in various brain diseases. We showed previously that NMDAR positive allosteric modulator GNE-8324 and M-8324 selectively increase...

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Bibliographic Details
Main Authors: Dan Xia, Xinyang Zhang, Di Deng, Xiaoyan Ma, Samer Masri, Jianzheng Wang, Shaowen Bao, Songnian Hu, Qiang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
NMDAR-positive allosteric modulator
RNA-seq
electrophysiological recording
potassium channels
cell adhesion molecules
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.796179/full

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