Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor
The Phosphatase and tensin homolog (PTEN) gene is one of the most important tumor suppressor genes, which acts through its unique protein phosphatase and lipid phosphatase activity. PTEN protein is widely distributed and exhibits complex biological functions and regulatory modes. It is involved in t...
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| Format: | Article |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.684529/full |
| _version_ | 1818454894574567424 |
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| author | Tianyu He Xiaoyun Zhang Jianyu Hao Shigang Ding |
| author_facet | Tianyu He Xiaoyun Zhang Jianyu Hao Shigang Ding |
| author_sort | Tianyu He |
| collection | DOAJ |
| description | The Phosphatase and tensin homolog (PTEN) gene is one of the most important tumor suppressor genes, which acts through its unique protein phosphatase and lipid phosphatase activity. PTEN protein is widely distributed and exhibits complex biological functions and regulatory modes. It is involved in the regulation of cell morphology, proliferation, differentiation, adhesion, and migration through a variety of signaling pathways. The role of PTEN in malignant tumors of the digestive system is well documented. Recent studies have indicated that PTEN may be closely related to many other benign processes in digestive organs. Emerging evidence suggests that PTEN is a potential therapeutic target in the context of several non-neoplastic diseases of the digestive tract. The recent discovery of PTEN isoforms is expected to help unravel more biological effects of PTEN in non-neoplastic digestive diseases. |
| first_indexed | 2024-12-14T22:02:08Z |
| format | Article |
| id | doaj.art-0ea3a696bfa04e0d8971faf6c08c60da |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-14T22:02:08Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-0ea3a696bfa04e0d8971faf6c08c60da2022-12-21T22:45:57ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-06-011210.3389/fphys.2021.684529684529Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor SuppressorTianyu He0Xiaoyun Zhang1Jianyu Hao2Shigang Ding3Department of Gastroenterology, Peking University Third Hospital, Beijing, ChinaDepartment of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Peking University Third Hospital, Beijing, ChinaThe Phosphatase and tensin homolog (PTEN) gene is one of the most important tumor suppressor genes, which acts through its unique protein phosphatase and lipid phosphatase activity. PTEN protein is widely distributed and exhibits complex biological functions and regulatory modes. It is involved in the regulation of cell morphology, proliferation, differentiation, adhesion, and migration through a variety of signaling pathways. The role of PTEN in malignant tumors of the digestive system is well documented. Recent studies have indicated that PTEN may be closely related to many other benign processes in digestive organs. Emerging evidence suggests that PTEN is a potential therapeutic target in the context of several non-neoplastic diseases of the digestive tract. The recent discovery of PTEN isoforms is expected to help unravel more biological effects of PTEN in non-neoplastic digestive diseases.https://www.frontiersin.org/articles/10.3389/fphys.2021.684529/fullPTENtumor suppressorPI3K/AKT pathwaydigestive organsinfectioninflammation |
| spellingShingle | Tianyu He Xiaoyun Zhang Jianyu Hao Shigang Ding Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor Frontiers in Physiology PTEN tumor suppressor PI3K/AKT pathway digestive organs infection inflammation |
| title | Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor |
| title_full | Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor |
| title_fullStr | Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor |
| title_full_unstemmed | Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor |
| title_short | Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor |
| title_sort | phosphatase and tensin homolog in non neoplastic digestive disease more than just tumor suppressor |
| topic | PTEN tumor suppressor PI3K/AKT pathway digestive organs infection inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.684529/full |
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